Our paper is finally out! 🥳 If you want to know how a single Salmonella effector rewires the whole macrophage transcriptional landscape by hijacking one host transcription factor, check our latest research! Thanks to the @thurstonlab.bsky.social and @peterwshill.bsky.social labs for an amazing work!

Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

The ability of Salmonella Typhimurium to exploit macrophages as a niche for survival, replication, and dissemination is central to its pathogenesis. T…

sciencedirect.com

We had a fantastic time today showcasing our amazing history and cutting-edge research at #OxfordOpenDoors! Visitors learnt about 100 years of medical research, the development of penicillin and our ongoing work on microbiology and AMR. Thanks to all the volunteers!

Great time showcasing the amazing science we do at the @dunnschool.bsky.social at #OxfordOpenDoors today!

We have a new preprint on Salmonella effector SteE! Here we describe how kinase reprogramming drives transcriptional remodelling of the infected macrophage www.biorxiv.org/cgi/content/... - work led by @ines-ddo.bsky.social and fantastic collaboration with @peterwshill.bsky.social

Salmonella Effector SteE Reprogrammes the Macrophage Regulatory Network to Drive Specific Hyperactivation of STAT3 Target Genes

The ability of Salmonella Typhimurium to exploit macrophages as a niche for survival, replication and dissemination is central to its pathogenesis. The effector SteE, which polarises macrophages into ...

biorxiv.org

It’s been a pleasure to attend and present my research at #ETOX2025! It’s amazing to see all the exciting science happening in the field!

We recently had a day of Salmonella-focused fun. Special thanks to @eadirectordndi.bsky.social and PhD student Kelvin Kerring for joining us from Kenya to discuss iNTS. All made possible via the Global hubs fund and @embo.org YIP networking fund. @jayhinton.bsky.social @katrinrittinger.bsky.social

How can a Salmonella effector change the specificity of a host kinase? SteE mediates kinase reprogramming via mimicry of conserved eukaryotic-like motifs- doi.org/10.1038/s443... Great collaboration with @katrinrittinger.bsky.social + big thanks to all authors & congrats to lead PDRA Ioanna Panagi!

Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs | EMBO reports

imageimageA virulence protein from diverse bacteria switches the amino acid specificity of the eukaryotic kinase GSK3. This kinase reprogramming depends on several short linear motifs that each appear...

embopress.org

During my PhD at @crick.ac.uk and @imperialcollegeldn.bsky.social, I explored the molecular interaction between host and pathogen. My question: How have pathogenic bacteria evolved to manipulate their host environment during infection? 🦠https://biorxiv.org/content/10.1101/2025.03.01.640964v1 1/11