We have a postdoc position available in the lab and would like to spread the word. Please apply if you are interested! www.cam.ac.uk/jobs/researc...

Five years ago I started studying a fascinating protein of Salmonella, called SteC.

I’m excited to share some of my postdoctoral work from the Francis Crick Institute / GSK Prosperity Partnership is now live on ChemRxiv, here: chemrxiv.org/doi/full/10.... Huge thanks to all authors – especially @katrinrittinger.bsky.social and Jake Bush for letting me run with the ideas!

We are looking for a new RA to join our team working on host-pathogen interactions during Salmonella infection. The appointment is for two years and you will join a diverse team, using cell and protein biochemistry to further our understanding of pathogenesis. my.corehr.com/pls/uoxrecru...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

Excited to Salmonella effector SteE featured on the cover of EMBO reports www.embopress.org/journal/1469...

EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

embopress.org

EMBO Reports@emboreports.org · last yr.

Second July issue is live. -> www.embopress.org/toc/14693178... featuring work by Teresa Thurston, Katrin Rittinger and co-workers @thurstonlab.bsky.social @katrinrittinger.bsky.social @dunnschool.bsky.social @imperialcollegeldn.bsky.social @crick.ac.uk. More: www.embopress.org/doi/full/10....

📣Preprint 📣 You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...

Light-Activated Metal-dependent Protein Degradation (LAMP-D): A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1

The growth of antimicrobial resistance (AMR) is a significant global health threat, yet despite this alarming trend, antibiotic drug discovery has significantly slowed. Most compounds entering the cli...

doi.org

Second July issue is live. -> www.embopress.org/toc/14693178... featuring work by Teresa Thurston, Katrin Rittinger and co-workers @thurstonlab.bsky.social @katrinrittinger.bsky.social @dunnschool.bsky.social @imperialcollegeldn.bsky.social @crick.ac.uk. More: www.embopress.org/doi/full/10....

New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs. By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis. www.biorxiv.org/content/10.1...

Very happy to share two back-to-back preprints of my postdoc work on bacterial NEL E3 ligases from my time in @katrinrittinger.bsky.social lab at @crick.ac.uk in collaboration with the ChemBio team at GSK (1/4)

How can a Salmonella effector change the specificity of a host kinase? SteE mediates kinase reprogramming via mimicry of conserved eukaryotic-like motifs- doi.org/10.1038/s443... Great collaboration with @katrinrittinger.bsky.social + big thanks to all authors & congrats to lead PDRA Ioanna Panagi!

Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs | EMBO reports

imageimageA virulence protein from diverse bacteria switches the amino acid specificity of the eukaryotic kinase GSK3. This kinase reprogramming depends on several short linear motifs that each appear...

embopress.org

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW 🥳 🍾 🙌 @katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...

rdcu.be

New preprint on how a minimal Salmonella kinase needs a host kinase to activate it. Work led by @timeshpillay.bsky.social and another great collaboration with @katrinrittinger.bsky.social @crick.ac.uk biorxiv.org/content/10.1...

Salmonella effector kinase SteC is activated by host-mediated phosphorylation

The pathogen Salmonella , which causes significant human morbidity and mortality, encodes an effector kinase, SteC, which mediates actin polymerisation and cell migration. Given the minimal nature of ...

biorxiv.org

Looking forward to the monthly on-line seminars organized by the Protein Modules Community @pmc-modularity.bsky.social and talks on SLiMs, systems biology, signaling, computational biology and much more. First talks by Dr Gogl @teamgogl.bsky.social and Dr Dionne @gingraslab.bsky.social.

PMC Protein Modules Community@pmc-modularity.bsky.social · 2y ago

Join us for our new online seminar series, featuring two talks on protein modules every month! The first session kicks off at 6pm CET Feb 10 with Dr. Gergő Gógl and Dr. Ugo Dionne. Register to attend: tinyurl.com/register-pmc-seminar

Happy to share our new paper, out now in @commschem.bsky.social. Was great working with Aini and @katmcphie.bsky.social on this! We used chemoproteomics and HTC to find an enantioselective hit for OTUD7B. www.nature.com/articles/s42... @katrinrittinger.bsky.social @jtbush.bsky.social @crick.ac.uk

Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation - Communications Chemistry

The ovarian tumour protease (OTU) family of deubiquitinating enzymes (DUBs) are biochemically well-characterised and of therapeutic interest, however, only a few tool compounds exist to study their ce...

nature.com

Excited to share a key part of my postdoctoral work from @crick.ac.uk and GSK, published in Nature Communications. A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems. www.nature.com/articles/s41...

Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - Nature Communications

This paper presents a label-free chemoproteomics platform using data-independent acquisition to profile covalent fragment binding across the human proteome. The platform offers high reproducibility an...

nature.com

If you are interested in 𝗔𝗰𝘁𝗶𝘃𝗶𝘁𝘆-𝗕𝗮𝘀𝗲𝗱 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗣𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴, definitely consider the #ABPP2025 conference on March 30th to April 2nd, 2025, at The Francis Crick Institute. Registration deadlines have been updated. www.linkedin.com/posts/14th-i...

14th International Activity Based Protein Profiling (ABPP) Meeting on LinkedIn: REGISTRATIONS DEADLINES UPDATE! Early Bird registration (🐣) has been…

REGISTRATIONS DEADLINES UPDATE! Early Bird registration (🐣) has been extended to the 30th of January and Late Registrations (🦉) end on the 28th of February…

linkedin.com