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Infectious Disease Advisor

@infectiousdisease.bsky.social

Infectious Disease Advisor is an online resource for health care professionals who treat patients with infectious diseases.

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Infectious Disease Advisor @infectiousdisease.bsky.social · yesterday

Among older adults with #influenza or #pneumonia, #sepsis-related mortality rates increased over time, with significant geographic and demographic disparities, highlighting the need for enhanced clinical vigilance and optimized health care access in vulnerable populations. #HealthDisparities #IDSky

Sepsis-Related Mortality Rises Among Older Adults With Influenza, Pneumonia

A retrospective study shows rising sepsis-related mortality in older adults with influenza or pneumonia, peaking in 2021.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 2d ago

From @cidjournal.bsky.social 💉 Seasonal #InfluenzaVaccination in 2024-2025 offered moderate outpatient protection, with effectiveness varying by virus strain and age, underscoring the importance of #immunization. #IDSky

Influenza Vaccine Provided Moderate Outpatient Protection During 2024-2025 Season

The 2024-2025 US influenza vaccine provided moderate protection against outpatient illness, reducing medically attended visits by one-third.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 2d ago

Total hip or knee #arthroplasty within 4 weeks of #COVID19 diagnosis is associated with increased postoperative complications, highlighting the need for a timing-based approach.

Arthroplasty Within 4 Weeks of COVID-19 Heightens Postoperative Risks

Postoperative risks for sepsis and pulmonary embolism are highest when joint arthroplasty occurs within 4 weeks of COVID-19 diagnosis.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3d ago

Women with #LongCOVID report higher overall #neurologic symptom burden and greater fatigue than men, regardless of prior hospitalization status, emphasizing the need for prompt diagnostic recognition and targeted management strategies tailored to female patients. #HealthDisparities #IDSky

Women Exhibit Greater Neurologic Symptom Burden After Long COVID

Women with long COVID experience higher neurologic symptom burden and worse fatigue than men, regardless of hospitalization status.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 5d ago

Real-world findings demonstrate high virologic suppression and safety after switching to bictegravir plus emtricitabine and tenofovir alafenamide in adults with #HIV, supporting its use in routine care. #IDSky

Real-World Data Support BIC/FTC/TAF Switch in Adults With HIV

Switching to BIC/FTC/TAF is safe and maintains high virologic suppression among virologically suppressed adults with HIV infection.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 6d ago

From @cidjournal.bsky.social 🦠 Long-acting #AntiretroviralTherapy supports virologic suppression in people with #HIV facing adherence barriers and baseline viremia, highlighting its clinical utility in real-world settings. #IDSky

Long-Acting ART Achieves HIV Virologic Suppression in Patients With Viremia

Real-world data demonstrate high rates of viral suppression among PWH with viremia who initiate LA CAB/RPV.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 6d ago

#ICYMI: Updated '25-'26 formulations of #COVID19 vaccines are effective in reducing risk for hospitalization and illness, highlighting the importance of #vaccination in adults 65+. Read more ⬇️ https://www.infectiousdiseaseadvisor.com/news/mrna1283-bnt162b2-covid19-effectiveness-older-adults/

Infectious Disease Advisor @infectiousdisease.bsky.social · last wk.

From @jidjournal.bsky.social 💉 Phase 3 trial data show an mRNA-1345 booster at 24 months maintains safety and revives antibody responses against #RespiratorySyncytialVirus in older adults, highlighting potential revaccination strategies to ensure sustained protection against #RSV disease. #IDSky

mRNA-1345 Revaccination Maintains RSV Immune Responses in Older Adults

An RSV mRNA vaccine booster administered at 24 months shows noninferior antibody responses and favorable safety in older adults.

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Infectious Disease Advisor @infectiousdisease.bsky.social · last wk.

Patient-related factors drive short-term mortality in #StaphylococcusAureus #bacteremia, with intensive care admission and older age increasing risk, highlighting the need for early risk stratification. #IDSky

Patient Factors Predict Staphylococcus aureus Bacteremia Mortality

Short-term mortality in Staphylococcus aureus bacteremia aligns with age, ICU admission, and elevated Pitt Bacteremia Scores.

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Infectious Disease Advisor @infectiousdisease.bsky.social · last wk.

Tenofovir alafenamide fumarate achieves #ViralSuppression rates comparable to tenofovir disoproxil fumarate in patients with chronic #HepatitisB virus infection, with an improved safety profile, highlighting its potential to optimize clinical outcomes while minimizing organ toxicity. #IDSky

TAF vs TDF for Chronic HBV: Comparable Efficacy With Improved Safety Profile

TAF demonstrates similar efficacy to TDF for chronic HBV but offers an improved safety profile.

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Infectious Disease Advisor @infectiousdisease.bsky.social · last wk.

Despite cohort-level declines, #HepatitisB coinfection remains more prevalent among younger adults with #HIV than estimates reported for the general population, underscoring ongoing #vaccination and prevention needs. #IDSky

Childhood HBV Vaccination May Reduce HBV Coinfection in People With HIV

PWH born after 1980 show a lower prevalence of HBV coinfection compared with older cohorts, likely reflecting childhood vaccination.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

From @basucally.bsky.social 🦠 Prescription patterns in the US indicate #oseltamivir is the leading outpatient #influenza #antiviral, whereas #peramivir is increasingly favored for inpatients, highlighting the clinical alignment of antiviral selection with specific care settings. #IDSky

Oseltamivir Remains Most Common Influenza Antiviral Prescribed in the US

A study of insured US patients shows that oseltamivir is the primary influenza antiviral, while inpatient use of peramivir continues to grow.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

Dr Monica Gandhi MD, MPH, of @ucsfhealth.bsky.social and @zsfgcare.bsky.social discusses the systemic challenges and containment infrastructure required to manage resurgent communicable diseases like #measles, #HIV, and #mpox. #IDSky Read more ⬇️

Recent Infectious Disease Outbreaks Expose Critical Gaps in Public Health

Infectious disease outbreaks, such as measles, HIV, and mpox, expose critical vulnerabilities across public health systems.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

From @ofidjournal.bsky.social 🦠 Adults with high-risk conditions demonstrate higher rates of #RespiratorySyncytialVirus-associated lower #RespiratoryTract disease than adults without these conditions, with particularly elevated risk among younger adults aged 18 to 49 years. #IDSky

High-Risk Conditions Linked to Greater RSV Lower Respiratory Disease Burden

Adults aged 18 to 64 years with high-risk conditions demonstrate higher rates of RSV-related LRTD than those without these conditions.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

🚨From @medicalprofref.bsky.social 🚨 In response to a rising multistate outbreak of #Cyclospora infections, the #CDC issued a health advisory for clinicians with recommendations for managing suspected cases of #cyclosporiasis. #IDSky Read more ⬇️

CDC Issues Alert on Rising Multistate Cyclospora Outbreak

Clinicians should maintain a high index of suspicion for Cyclospora in patients with prolonged or relapsing watery diarrhea this summer.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

Although case growth has moderated, #CandidaAuris infections and transmission continue to rise within US health care facilities, highlighting the expanding challenges of managing multidrug-resistant pathogens across #AcuteCare settings. #IDSky

MMWR Highlights: Candida auris Surveillance Shows Continued Rise in US Cases

Surveillance data show a continuous increase in US C auris clinical cases and colonization, highlighting a persistent health care threat.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

From @jamanetworkopen.com 🦠 Real-time EHR alerts significantly increase #chlamydia screening orders in primary care settings, highlighting the utility of integrating targeted digital prompts into clinical workflows to optimize routine preventive screening rates among eligible young women. #IDSky

Direct EHR Alert Improves Chlamydia Screening Among Women in Primary Care

An EHR alert for medical assistants significantly increases chlamydia screening orders in primary care but not in obstetrics-gynecology clinics.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

From @jamanetworkopen.com 💉 The 2025-2026 #COVID19Vaccines provided protection against medically attended infection in immunocompetent adults, highlighting the capacity of targeted #immunizations to mitigate severe clinical outcomes associated with circulating viral lineages. #IDSky

Updated 2025-2026 COVID-19 Vaccines Effective Against Medically Attended Disease

The 2025-2026 SARS-CoV-2 vaccines provided protection against ED/UC visits and hospitalizations among immunocompetent adults.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

From @jamanetworkopen.com 💉 #Vaccine effectiveness varied across different age demographics and virus strains, offering the highest protection against #InfluenzaB and among children/adolescents during the 2024-2025 season, highlighting the importance of maintaining robust #immunization strategies.

Influenza Vaccine Reduced Mortality Risk During the 2024-2025 Season

Immunization with the 2024-2025 influenza vaccine reduced influenza positivity and related mortality.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

From @cidjournal.bsky.social 🦠 Implementation of a molecular #pneumonia panel improves early #antibiotic optimization for critically ill patients, highlighting how pairing advanced testing with robust stewardship infrastructure successfully drives critical care precision. #IDSky

Rapid Pneumonia Panel Improves Early Antibiotic Optimization

Implementation of a rapid molecular pneumonia panel is associated with earlier antimicrobial optimization among critically ill patients with pneumonia.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 3w ago

From @jamanetworkopen.com 💉 In older adults, high-dose inactivated #InfluenzaVaccine demonstrates superior relative effectiveness to a standard dose for preventing hospitalizations, highlighting the clinical value of higher antigen concentrations in addressing age-related immune response variations.

High-Dose Influenza Vaccine Reduces Hospitalizations in Older Adults

A meta-analysis indicates HD-IIV is superior to SD-IIV for reducing hospitalizations in adults aged 65 years and older.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 4w ago

From @ofidjournal.bsky.social 🦠 Individuals hospitalized with #WestNileVirus often experience ongoing #PhysicalDisability 2 years later, highlighting the enduring clinical burden and the need for proactive clinician counseling and family education regarding long-term recovery support. #IDSky

Long-Term Sequelae Common After West Nile Virus

Patients hospitalized for WNV frequently experience physical and mental long-term sequelae 2 years after hospital discharge.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 4w ago

From @schoolofppls.bsky.social 🦠 #Prenatal exposure to #SARSCoV2 does not appear to affect early childhood #neurodevelopmental outcomes, though longer monitoring is recommended. #IDSky

Prenatal SARS-CoV-2 Exposure Does Not Affect Early Childhood Neurodevelopment

Maternal SARS-CoV-2 infection during pregnancy does not significantly alter early childhood neurodevelopmental outcomes in a meta-analysis.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 4w ago

From @plosone.org 🦠 A retrospective cohort study reveals that #SteroidUse during acute #SARSCoV2 infection is not associated with a reduced risk for pediatric #LongCOVID. #IDSky @pccmcore.bsky.social @grantschulert.bsky.social

Steroid Use During Acute COVID-19 Not Linked to Lower Long COVID Risk in Children

Corticosteroids administered during acute SARS-CoV-2 infection fail to lower the risk of developing long COVID in pediatric patients.

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Infectious Disease Advisor @infectiousdisease.bsky.social · 4w ago

Optimizing maternal #COVID19 and #InfluenzaVaccine coverage during the gestational period significantly increases subsequent infant #immunization rates, establishing a critical clinical paradigm for reinforcing continuous early-life immunity. #IDSky @ameracadpeds.bsky.social

Maternal Immunization Boosts Infant Influenza and COVID-19 Vaccine Uptake

Maternal COVID-19 and influenza vaccination during pregnancy is associated with significantly higher rates of corresponding infant vaccination.

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Infectious Disease Advisor @infectiousdisease.bsky.social · last mo.

Findings from the ACTIV-6 trial indicate that #metformin therapy fails to provide a significant benefit for preventing #LongCOVID in low-risk, immune adults.

Metformin Fails to Reduce Long COVID Risk in Low-Risk Adults

Metformin does not significantly reduce the risk for long COVID at 6 months in low-risk adults with high baseline immunity to the virus.

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Infectious Disease Advisor @infectiousdisease.bsky.social · last mo.

From @thelancetinfdis.bsky.social 🦠 Statewide #doxycycline post-exposure prophylaxis implementation shows limited effectiveness against #gonorrhea due to expanding #AntibioticResistance. @dhelekal.bsky.social @yhgrad.bsky.social @ucberkeleyofficial.bsky.social @hsph.harvard.edu

Doxycycline PEP Shows Limited Efficacy for Gonorrhea Prevention

A surge in tetracycline resistance reduces the clinical benefit of doxycycline PEP against gonorrhea in high-risk populations.

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Infectious Disease Advisor @infectiousdisease.bsky.social · last mo.

The #CDC issued updated operational guidance for investigating autochthonous #malaria cases within the United States. #IDSky #PublicHealth

CDC Updates Guidance for Investigation of Locally-Acquired Malaria in the US

The CDC released updated operational guidance for investigating locally-acquired mosquito-transmitted malaria in the US.

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Infectious Disease Advisor @infectiousdisease.bsky.social · last mo.

#Metformin may be effective in reducing severe #COVID19 outcomes among adults, although further research is highly warranted. #IDSky

Metformin May Improve COVID-19 Outcomes

Metformin use may lower the risk for a composite of hospitalization, ED visits, or death in adult patients with acute COVID-19.

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Infectious Disease Advisor @infectiousdisease.bsky.social · last mo.

From @jamapediatrics.com 🦠 An invasive #BacterialInfection prevalence of 1.11% among well-appearing febrile infants aged 60 to 90 days — predominantly #bacteremia — establishes contemporary data to optimize management protocols and guide collaborative clinical decision-making. #IDSky

About 1 in 90 Febrile Infants Aged 60 to 90 Days Have Invasive Bacterial Infection

An analysis of term infants shows that IBIs, mostly bacteremia, occur in a small percentage of febrile cases.

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