This is such amazing and elegant work using the power of #Drosophila to find such exciting and intriguing insights about breathing! Kudos to the entire team 👏🏽🎉🥳

Yichen Luo 骆奕辰@camellyc.bsky.social · 2d ago

1/8 Breathing seems automatic. But it's a finely tuned motor behavior that has to be controlled. In this preprint, I map the circuits that match a fly's respiration to the metabolic demands of flight and mitigate the risk of dehydration. 🧵🪰 www.biorxiv.org/content/10.6...

Morales Chaya, G. N., Syed, M. H. (2025). Cell cycle-dependent cues regulate temporal patterning of the Drosophila central brain neural stem cells. bioRxiv pubmed.ncbi.nlm.nih.gov/39868166/

Wang, R., ..., Amoyel, M. (2025). Signals from the niche promote distinct modes of translation initiation to control stem cell differentiation in the Drosophila testis. PLoS Biol, 23(3):e3003049https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003049

Matias, N. R., Gallicchio, L., Lu, D., Kim, J. J., Perez, J., Detweiler, A. M., Lu, C., Bolival, B., Fuller, M. T. (2025). A cell-type specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage. bioRxiv, www.biorxiv.org/content/10.1...

Segura, R. C., Gallaud, E., von Barnau Sythoff, A., Aavula, K., Taylor, J. A., Vahdat, D., Pielage, J., Cabernard, C. (2025). Protein phosphatase 4 is required for centrosome asymmetry in fly neural stem cells. bioRxiv, www.biorxiv.org/content/10.1...

Eldridge-Thomas, B. L., Bohere, J. G., ..., Samuels, T. J., Teixeira, F. K., Kolangar, G. (2025). The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties. PLoS genetics, 21(2):e1011586 journals.plos.org/plosgenetics...

The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties

Author summary Most tissues are built and maintained by stem cells that divide to produce correct cell types in response to environmental cues. In high turnover tissues, such as the intestine, a funda...

journals.plos.org

Stricker, A. M., Hutson, M. S., Page-McCaw, A. (2025). Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane. Dev Cell, www.cell.com/developmenta...

Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane

Basement membranes are a conserved extracellular matrix that provide support to tissues, yet little is known about their repair. Stricker et al. find that in the Drosophila midgut, basement membrane d...

cell.com

Morales Chaya, G. N., Syed, M. H. (2025). Cell cycle-dependent cues regulate temporal patterning of the Drosophila central brain neural stem cells. bioRxiv, www.biorxiv.org/content/10.1...

Wang, R., Roiuk, M., Storer, F., Teleman, A. A., Amoyel, M. (2025). Signals from the niche promote distinct modes of translation initiation to control stem cell differentiation and renewal in the Drosophila testis. PLoS Biol, 23(3):e3003049 journals.plos.org/plosbiology/...

Signals from the niche promote distinct modes of translation initiation to control stem cell differentiation and renewal in the Drosophila testis

Transcription is known to tightly regulate gene expression profiles in stem and differentiating cells, but less is known about the role of translational control. This study identifies that signals fro...

journals.plos.org

Matias, N. R., Gallicchio, L., Lu, D., Kim, J. J., Perez, J., Detweiler, A. M., Lu, C., Bolival, B., Fuller, M. T. (2025). A cell-type specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage. bioRxiv, www.biorxiv.org/content/10.1...

Segura, R. C., Gallaud, E., von Barnau Sythoff, A., Aavula, K., Taylor, J. A., Vahdat, D., Pielage, J., Cabernard, C. (2025). Protein phosphatase 4 is required for centrosome asymmetry in fly neural stem cells. bioRxiv, www.biorxiv.org/content/10.1...

Eldridge-Thomas, B., Bohere, J., Roubinet, C., Barthelemy, A., Samuels, T., Teixeira, F.., Kolangar, G. (2025). The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties. PLoS genetics, 21(2):e1011586 journals.plos.org/plosgenetics...

The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties

Author summary Most tissues are built and maintained by stem cells that divide to produce correct cell types in response to environmental cues. In high turnover tissues, such as the intestine, a funda...

journals.plos.org

Stricker, A. M., Hutson, M. S., Page-McCaw, A. (2025). Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane. Dev Cell www.cell.com/developmenta...

Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane

Basement membranes are a conserved extracellular matrix that provide support to tissues, yet little is known about their repair. Stricker et al. find that in the Drosophila midgut, basement membrane d...

cell.com

Komarov, N., Fritsch, C., Maier, G., ...., Dodero, A., Kwon, J. Y., Deplancke, B., Sprecher, S. G. (2025). Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology. PLoS biology, 23(1):e3002730 journals.plos.org/plosbiology/...

Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology

Sensing food is a complex multisensory experience. This study of food hardness preference in fruit fly larvae reveals that gustatory organ sensory neurons can perceive cues of both chemical and mechan...

journals.plos.org

Puri, S., Nath, D. K., Lee, Y. (2025). Regulation of feeding and defecation in Drosophila by trpgamma, piezo, and DH44R2. Insect Biochem Mol Biol, 179:104267 www.sciencedirect.com/science/arti...

Chvilicek, M. M., Titos, I., Merrill, C. B., Cummins-Beebee, P. N., Chen, J. D., Rodan, A. R., Rothenfluh, A. (2025). Alcohol induces long-lasting sleep deficits in Drosophila via subsets of cholinergic neurons. Current biology : CB, 35(5):1033-1046 www.cell.com/current-biol...

Alcohol induces long-lasting sleep deficits in Drosophila via subsets of cholinergic neurons

Chvilicek et al. show that, like humans, Drosophila melanogaster develop long-lasting sleep deficits arising from high doses of ethanol. Mechanistic studies show that silencing of cholinergic neurons ...

cell.com

Singh, A., Basu, A., Shit, B., Hegde, T., Bansal, N., Prasad, N. G. (2025). Experimental adaptation to singular pathogen challenge reduces susceptibility to novel pathogens in Drosophila melanogaster. Curr Res Insect Sci, 7:100105 www.sciencedirect.com/science/arti...

Bidros, J., Brock, K., Gard, J., Cooper, R. (2024). The Effect of Magnesium Concentration on Myogenic Cardiac Function: Larval Drosophila. MicroPubl Biol, 2024 pmc.ncbi.nlm.nih.gov/articles/PMC...

Ali, M. Y., Lu, H., Fagnant, P. M., Macfarlane, J. E., Trybus, K. M. (2025). BicD and MAP7 collaborate to activate homodimeric Drosophila kinesin-1 by complementary mechanisms. bioRxiv, www.biorxiv.org/content/10.1...

Nagy, A., Kovacs, L., Rangone, H., Fu, J., Ladinsky, M., Glover, D. M. (2025). Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation. Open biology, 15(2):240325 royalsocietypublishing.org/rsob/article...

Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation

Abstract. The conserved process of centriole duplication requires the establishment of a Sas6-centred cartwheel initiated by Plk4’s phosphorylation of Ana1

royalsocietypublishing.org

Porfi­rio-Rodrigues, P., Pereira, T., Jacinto, A., Carvalho, L. (2025). Dachsous is a key player in epithelial wound closure through modulating cell shape changes and tissue mechanics. Journal of cell science, 138(5) journals.biologists.com/jcs/article/...

Dachsous is a key player in epithelial wound closure through modulating cell shape changes and tissue mechanics

Highlighted Article: The Drosophila atypical cadherin Ds is essential for epithelial wound closure, influencing cell shape changes and rearrangements and tissue mechanics, with occluding junctions reg...

journals.biologists.com

Bakshinska, D., Liu, W. Y., Schultz, R., ...., Younger, S. H., Newman, Z. L., Isacoff, E. Y. (2025). Synapse-specific catecholaminergic modulation of neuronal glutamate release. Proceedings of the National Academy of Sciences www.pnas.org/doi/10.1073/...

M'Angale, P. G., Lemieux, A., Liu, Y., Wang, S., Zinter, M., Alegre, G., Simkin, A., Budnik, V., Kelch, B. A., Thomson, T. (2025). Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. PLoS Biol, 23(2):e3002983 journals.plos.org/plosbiology/...

Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila

Transposons are parasitic genome elements that serve as raw material for the evolution of new cellular functions. In this study, the capsid of the virus-derived retrotransposon Copia is shown to media...

journals.plos.org

Chen, T., Fernandez-Espartero, C., Giannone, G. (2025). Single-Molecule Tracking and Super-Resolution Microscopy Unveil Actin-Driven Membrane Nanotopography Shaping Stable Integrin Adhesions in Developing Tissue. Cytoskeleton (Hoboken, NJ), 82(7):471-474 onlinelibrary.wiley.com/doi/10.1002/...

Mandal, N., Das, A., Datta, R. (2025). Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII. Neurobiology of disease, 206:106825 www.sciencedirect.com/science/arti...

Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII

Cognitive disability and neurodegeneration are prominent symptoms of Mucopolysaccharidosis VII (MPS VII), a lysosomal storage disorder caused by β-glu…

sciencedirect.com

Prifti, M. V., Nuga, O., ...., Richardson, K., Todi, S. V. (2025). Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII. Neurobiology of disease, 207:106834 www.sciencedirect.com/science/arti...

Mosley, O. L., Villa, J. A., Kamalakkannan, A., James, E., Hoffman, J. M., Lyu, Y. (2025). Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila. Geroscience, 47(3):4697-4709 link.springer.com/article/10.1...

Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila - GeroScience

Dietary restriction (DR) is widely considered to be one of the most potent approaches to extend healthy lifespan across various species, yet it has become increasingly apparent that DR-mediated longev...

link.springer.com

Mattins, F., Nagrath, S., Fan, Y., Manea, T. K. D., Das, S., Shankar, A., Tower, J. (2025). Machine Learning Scoring Reveals Increased Frequency of Falls Proximal to Death in Drosophila melanogaster. J Gerontol A Biol Sci Med Sci, 80(6) academic.oup.com/biomedgeront...

Machine Learning Scoring Reveals Increased Frequency of Falls Proximal to Death in Drosophila melanogaster

Abstract. Falls are a significant cause of human disability and death. Risk factors include normal aging, neurodegenerative disease, and sarcopenia. Drosop

academic.oup.com

Nedachi, T., Kawasaki, H., Inoue, E., Suzuki, T., Nakagawa-Yagi, Y., Ishida, N. (2025). Electric-field induced sleep promotion and lifespan extension in Gaucher's disease model flies. Biochem Biophys Rep, 41:101915 www.sciencedirect.com/science/arti...

Hu, C., Xu, X., Hu, X., Zhang, J., Shen, L. (2025). Edible plant oils with high n-3/n-6 polyunsaturated fatty acids ratio prolong the lifespan of Drosophila by modulating lipid metabolism. Food Chem, 474:143121 www.sciencedirect.com/science/arti...