Heading to the @ccsresearch.bsky.social IGNITE Summit in Toronto. Looking forward to connecting with CCS awardees from across Canada and engaging in needed discussion about diversity in oncology! #CancerResearch
Islam Elkholi
@iselkholi.bsky.social
MD, PhD｜Oncology Research Fellow, McGill U.｜ Metastasis, Dormancy & Targeted Therapies｜Writing｜Coffee｜Jazz/blues ｜🇪🇬➡️🇨🇦 Views are my own.
Looking forward to sharing our work in this meeting!
Metastasis Research Society@metastasisresearch.bsky.social · 10mo ago🚀 Two weeks to go! The ECR Meeting brings together early-career scientists driving the next wave of metastasis research. ⚡ Don’t miss: 💡 Inspiring talks from rising leaders 💬 Community-led discussions 🌍 A global metastasis community 🗓️ Register by Nov 18 ➜ bit.ly/4qyxE0o Program ➜ bit.ly/4qtpVR9
Stuck at home? Time to revisit the record collection! A record I caught this year in Chicago…
It has been fun editing this issue focused on Cell Signaling in JoVE! Check this protocol by Vianney and Lee on proximity labelling in Drosophila melanogaster. app.jove.com/v/68193/in-v...
<em>In Vivo</em> Application of TurboID-based Proximity Labeling in <em>Drosophila melanogaster</em>
Proximity labeling (PL) is a powerful method for mapping protein-protein interaction networks. Advances in labeling enzymes, especially TurboID, have ...
app.jove.com
CIHR will finally allow international PhD students to apply! A big step forward!
Thrilled to share our first clinical trial paper on prostate cancer cell dormancy induction using an epigenetic and differentiation strategy. This was a strong team effort between physicians and basic scientists leading to this innovative clinical trial. www.medrxiv.org/content/10.1...
A Pilot Study of the Combination of 5-Azacitidine and All-trans Retinoic Acid in Biochemically Recurrent Prostate Cancer.
Purpose: Biochemical recurrence (BCR) after definitive local therapy remains a major clinical challenge in prostate cancer (PCa), with heterogeneous disease trajectories and few established strategies...
medrxiv.org
I am very grateful to CCS for not only supporting my fellowship work but also investing in my career development and being part of academic journey!
Canadian Cancer Society Research@ccsresearch.bsky.social · last yr.Weekly #cancerresearch highlight: @iselkholi.bsky.social is investigating multiple mutations in a gene called BRAF to understand how they promote #cancer growth and treatment resistance. This could lead to new treatments and better survival for people with these mutations. Learn more: is.gd/eiibhA
Excited to share our latest discovery just published in Cancer Research. lnkd.in/e_vNXXJC ⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer. @jf-cotelab.bsky.social
New vulnerability of dormant breast cancer cells dependent on a specific isoform of PI3K revealed by Islam Elkholi, JF Cote and team @ircm.bsky.social. Really happy to see this paper out and to have been of service! aacrjournals.org/cancerres/ar...
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Abstract. Halting breast cancer metastatic relapse following primary tumor removal remains challenging due to a lack of specific vulnerabilities to target during the clinical dormancy phase. To identi...
aacrjournals.org
Glad to announce the 1st Basic & Clinical Oncology (BCO) conference on May 7 at the IRCM/Montreal as a partnership between 9 institutes/networks across Quebec! Clinical and basic cancer research abstracts are welcome (deadline April 6). More details: www.ircm.qc.ca/en/events/de... #Montreal #Quebec
🌕🌖🌗🌘🌑🌒🌓🌔Surveillez le ciel dans la nuit du 13 au 14 mars : une éclipse totale de Lune sera au rendez-vous! Cet événement astronomique sera visible depuis le Québec et débutera à 1 h 09 pour se terminer à 4 h 47. L’éclipse atteindra son apogée entre 2 h 59 et 3 h 31. Voici notre photo prise en 2015.
So happy to share the newest pre-print from the lab where we show that old age significantly changes the traits that evolve in established lung adenocarcinoma. This work sheds light into the importance of modeling age-related cancers in the context of old age. www.biorxiv.org/content/10.1...
Aging directs the differential evolution of KRAS-driven lung adenocarcinoma
Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer( [1][1], [2][2] ), is a disease of the elderly, with an average age of diagnosis of about 70 years of age( [3][3] ). Old...
biorxiv.org
Join us this Thursday on Zoom. Basic and Clinical Oncology Bench ↔️ Bedside Seminar Series. #cancer #oncology
Institut de recherches cliniques de Montréal (IRCM)@ircm.bsky.social · 2y agoOn February 6 at 3 p.m., don't miss the two virtual conferences offered by Drs. Lorenzo Ferri and Véronique Giroux as part of the next fundamental and clinical oncology seminar. 📍Info and registration: bit.ly/3PYvaay
I wanted to write briefly about a very pleasant experience we recently had coordinating and collaborating closely on competing publications with 2 other teams. 1/
Kicking off with sharing our latest discussion on breast cancer dormancy & how to bridge the gap between the bench & bedside! tinyurl.com/msctvab2 P.S. I post about metastasis/signaling, Jazz/Egyptian classics & interesting reads. Looking fwd to connecting with people disseminating from Twitter 😊
