Jaan Mannik
@jaanmannik.bsky.social
Professor of biophysics at the University of Tennessee, Knoxville. Studying self-organizing processes in bacterial cells and their cell cycle. volweb.utk.edu/~jmannik/
📢Our MD simulation is out in Biophysical Journal! The nonequilibrium polysome dynamics expands bacterial nucleoids and helps separate daughter chromosomes. Results agree with our previous experiments and extend our earlier model. authors.elsevier.com/a/1mBGt_9FM7... #Microbiology #Biophysics
Our latest work is out in PNAS!🎉 We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇 www.pnas.org/doi/10.1073/... #MicroSky #Microbiology #Biophysics #CellBiology
Bacteria lack a mitotic spindle—how do they segregate chromosomes? 🤓 Using quantitative microscopy and modeling, we show that polysome (mRNA–ribosome) dynamics contribute to chromosome separation in E. coli, but septum closure and potentially DNA entropic segregation mechanisms are also involved.
bioRxiv Biophysics@biorxiv-biophys.bsky.social · 2y agoThe role of active mRNA-ribosome dynamics and closing constriction in daughter chromosome separation in Escherichia coli https://www.biorxiv.org/content/10.1101/2025.04.05.647368v1
New exciting findings on E. coli cell division: Using high throughput imaging 🔬 & stochastic modeling, we show that FtsZ—not FtsN—drives constriction at fast growth rates. Great collaboration with @arielamir.bsky.social and @KarPrathitha www.nature.com/articles/s41... #Microbiology #CellBiology
Determining the rate-limiting processes for cell division in Escherichia coli - Nature Communications
The recruitment of protein FtsN to midcell is thought to be the main rate-liming process for cell division in the bacterial model E. coli. Here, Männik et al. use experiments with live bacteria as wel...
nature.com