A tomato MIK2-clade receptor is involved in the perception of a Fusarium-derived elicitor Maroschek et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
Jack Rhodes
@jackrhodes.bsky.social
Postdoctoral 🌱 scientist at The Sainsbury Laboratory, Norwich. Interested in peptide-receptor and immune signalling. #plantscience
Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors. Huge thanks to our amazing co-authors for making this possible! doi.org/10.64898/202...
Computational design of de novo integrated domains enables rational control of pathogen effector recognition in plant NLR immune receptors.
The rapid evolution of plant pathogens poses a persistent threat to global agricultural sustainability, often outpacing the discovery and deployment of natural disease resistance genes. While bioengin...
doi.org
Time for another preprint from the lab: www.biorxiv.org/content/10.6... Led by @yuanyuanzhang.bsky.social and @defengshen.bsky.social. We found some surprising secrets that connect and uncouple root barrier formation with systemic nitrogen signaling in shoots. see the thread below for more details
A tunable receptor separates root barrier formation from nutrient signaling through ligand-perception states
In roots, the endodermis controls nutrient entry by forming a barrier known as the Casparian strip. Yet how barrier-associated processes interface with systemic signaling remains unclear. Here, we sho...
biorxiv.org
Host specificity in cereal rust fungi is mediated by a conserved glycoside hydrolase family https://www.biorxiv.org/content/10.64898/2026.05.20.726508v1
Breaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr
After USDA request, Indiana plant biologist locked out of lab by school
Move comes after Roger Innes complained about the government’s prosecution of Chinese postdocs
scim.ag
🔥 Hot new preprint before the Christmas break 🎄 Egg cell fertilization–dependent peptide receptor signaling mediates endosperm polarity 📖 www.biorxiv.org/content/10.6... Audrey Creff, @jackrhodes.bsky.social , Cyril Zipfel, Gwyneth Ingram and others
A mechanistic framework for the recognition of chemically diverse brassinosteroids by BRI1-family receptor kinases www.biorxiv.org/content/10.1...
A mechanistic framework for the recognition of chemically diverse brassinosteroids by BRI1-family receptor kinases
Brassinosteroids (BRs) are chemically diverse plant steroid hormones produced via a branched biosynthetic pathway. The potent BR brassinolide is sensed by the membrane receptor kinase BRI1 and a SERK ...
biorxiv.org
The sTDIF signaling peptide modulates the root stele diameter and primary metabolism to accommodate symbiotic nodulation: Current Biology www.cell.com/current-biol...
The sTDIF signaling peptide modulates the root stele diameter and primary metabolism to accommodate symbiotic nodulation
Teyssendier de la Serve et al. identify a novel symbiotic response induced by nitrogen-fixing rhizobia on host plant roots, corresponding to a stele diameter enlargement. This response requires a TDIF...
cell.com
New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions www.biorxiv.org/content/10.1...
biorxiv.org
Join us for the 🪴 🌵 Plant Peptide Receptor Meeting 2025 ☘️ 🪴 in 🏴 Edinburgh 🏴 8th-10th September #plantsignaling #PlantScience #plantsci pprm2025.events.kdmeventsportal.co.uk @pprm2025.bsky.social A thread 🧵 (1/n)
Plant Peptide Receptor Meeting 2025
pprm2025.events.kdmeventsportal.co.uk
Multiplexed profiling of transcriptional regulators in plant cells
Multiplexed profiling of transcriptional regulators in plant cells
Transcriptional regulatory domains play key roles in plant growth, development, and environmental responses. Massively parallel reporter assays in yeast and animal cells have enabled large-scale studi...
biorxiv.org
Very informative talk by @katherinedenby.bsky.social, EiC of @theplantjournal.bsky.social, on scientific publishing in the #PlantSciences. #MBP2025 Her points on how to choose a journal to publish in are below. Happy to see that my favorite journals fit the bill. 👌
PRESS RELEASE - Professor Uauy appointed as Director of the John Innes Centre Following an international search, we are delighted to announce that Professor @cristobaluauy.bsky.social has been appointed as the next Director of the John Innes Centre. www.jic.ac.uk/press-releas... @ukri.org
Professor Uauy appointed as Director of the John Innes Centre | John Innes Centre
Following an international search, Professor Cristóbal Uauy has been appointed as the next Director of the John Innes Centre. Professor Uauy is internationally recognised for his significant…
jic.ac.uk
Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants
Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants
Parasitic plants initiate rapid de novo organogenesis of a specialized feeding structure called a haustorium upon contact with their hosts. Currently, little is known about the internal signals regula...
biorxiv.org
A trehalase-derived MAMP triggers LecRK-V-mediated immune responses in Arabidopsis
A trehalase-derived MAMP triggers LecRK-V-mediated immune responses in Arabidopsis
Plant-parasitic nematodes (PPNs) cause major agricultural losses worldwide, yet the molecular basis of plant immunity against these pathogens remains poorly understood. To investigate how plants recog...
biorxiv.org
Endogenous RALF peptide function is required for powdery mildew host colonization
Endogenous RALF peptide function is required for powdery mildew host colonization
The receptor kinase FERONIA (FER) is a susceptibility factor for biotrophic powdery mildew fungal pathogens in Arabidopsis thaliana, but the underlying molecular mechanisms remain largely unknown. FER...
biorxiv.org
Immunity gene silencing increases transient protein expression in Nicotiana benthamiana
Immunity gene silencing increases transient protein expression in Nicotiana benthamiana
Agroinfiltration of Nicotiana benthamiana is routinely used for transient gene expression in plant sciences and molecular pharming. Here, we depleted transcripts of 21 different immunity-related genes...
biorxiv.org
Lighten up your life! We built a “darkbox” with a CCD camera to image bacterial infections across entire trays of Arabidopsis plants. Our technical advance with Python image analysis pipeline out now! @havandenburg.bsky.social @nwtaks.bsky.social bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...
Non‐Invasive, Bioluminescence‐Based Visualisation and Quantification of Bacterial Infections in Arabidopsis Over Time
Development of a non-invasive high-throughput phenotyping pipeline to visualise and quantify progression of bioluminescent bacterial pathogens in Arabidopsis rosettes over time.
bsppjournals.onlinelibrary.wiley.com
Simulating 500 million years of evolution with a language model www.science.org/doi/10.1126/...
Simulating 500 million years of evolution with a language model
More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here we show that language models trained at scale on evolutionary data can gen...
science.org
Elemental cryo-imaging reveals SOS1-dependent vacuolar sodium accumulation
Elemental cryo-imaging reveals SOS1-dependent vacuolar sodium accumulation - Nature
This study demonstrates that cryo nanoscale secondary ion mass spectrometry (CryoNanoSIMS) enables direct multi-elemental imaging at subcellular resolution of macro- and micronutrients or trace elemen...
doi.org
Transposon-triggered epigenetic chromatin dynamics modulate EFR-related pathogen response www.nature.com/articles/s41...
Transposon-triggered epigenetic chromatin dynamics modulate EFR-related pathogen response - Nature Structural & Molecular Biology
Here, the authors show that an inverted-repeat transposon located next to the pattern recognition receptor ELONGATION FACTOR-TU RECEPTOR (EFR)-encoding gene in Arabidopsis controls chromatin organizat...
nature.com
Seed tuber microbiome can predict growth potential of potato varieties www.nature.com/articles/s41...
Seed tuber microbiome can predict growth potential of potato varieties - Nature Microbiology
Time-resolved drone imaging of potato crop development and seed tuber microbiome data can be used to predict potato vigour, or growth potential, in next-season crops in trial fields.
nature.com
Thrilled to share our work on an unusual EXO70 clade unique to grasses and grass-like species 🌾! (1/8) www.biorxiv.org/content/10.1... @thesainsburylab.bsky.social
Putative neofunctionalization of a Poales-specific EXO70 clade
EXO70s are uniquely expanded in land plants compared to all other eukaryotic lineages. The functional implications of this expansion and diversification on the conserved role of EXO70 as a subunit of ...
biorxiv.org
We found that in addition to lacking structural requirements for exocyst complex formation, EXO70FX12 lacks exocyst subunit associations in yeast, Nicotiana benthamiana, and barley. (6/8)
Happy to announce that NWO funded a project in which @cornepieterse.bsky.social and my team will explore the ancient links between rapid #auxin signaling and immune responses. My first careful steps in the plant-microbe interactions community… www.nwo.nl/en/news/twen...
📣 NEW VACANCY: Predoctoral Internship in the Cyril Zipfel group For: ▶️ Students considering future PhD studies ▶️ ‘Year-in-industry’ undergrads 🌱🧬 with an interest in plant science research ⏳Apply soon! Application review already starts 6 Jan '25 www.tsl.ac.uk/working-at-t...
📢 NEW VACANCY: Senior Laboratory Technician in the Cyril Zipfel group. 🌱 🛡️ Contribute to fundamental research on plant immunity 🧬 Conduct molecular biology experiments ⏳ Apply soon! Application review already starts 6 Jan '25 www.tsl.ac.uk/working-at-t...
📣 NEW VACANCY: Postdoctoral Scientist in the Cyril Zipfel group. 🌿 Decipher the molecular mechanisms underlying plant immunity 🌱 Identify & characterise pattern recognition receptors ⏳ Apply soon! Application review already starts 6 Jan '25 www.tsl.ac.uk/working-at-t...