Phenomenally proud that this work is out in the wild now - excellent feeling having my qXL-MS of myosin conformational dynamics paired with @snmcmillan.bsky.social incredible cryo-EM work and analysis. A real team effort from @scarfflab.bsky.social www.science.org/doi/10.1126/...

Mavacamten inhibits myosin activity by stabilizing the myosin interacting-heads motif and stalling motor force generation

Mechanism of the myosin inhibitor mavacamten is revealed by cryo-EM and cross-linking studies.

science.org

3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...

Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com

PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com

findaphd.com

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature

A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

nature.com

Really proud of the qXL-MS work developed to build this story with the beautiful Cryo-EM structures from @snmcmillan.bsky.social

Charlie Scarff@scarfflab.bsky.social · 2y ago

Mechanism of mavacamten inhibition of myosin - check out our preprint here: www.biorxiv.org/content/10.1...

Starting the year off right with a very pretty spectrum from an experiment showing no interaction between two proteins that should be interacting.

My gaming laptop was bought six years ago to mostly play CS:GO now its fragging of a different kind. 9 hours to searching....

Thank you to the angels who updated MSFragger and Skyline so analysis of MeroX data is somewhat practical just in time for my birthday! I’m just a women standing in front of buckets of qXL-MS needing to be analysed and not wanting to use xlinkx….

Last week the Scarff group hosted the Don of adenovirus myosin expression, this week I have to decipher my notes I took. Very excited to crack on with it!

UoLeeds are looking for a facility manager to join our team. If you want to be responsible for the day-to-day running of our mass spectrometry research service and facility equipment have a look at ad! Happy to answer queries! jobs.leeds.ac.uk/vacancy.aspx...

Job Opportunity at University of Leeds: Mass Spectrometry Facility Manager

jobs.leeds.ac.uk

Boy, would I love to chat to someone who’s got #skyline working for quantitative crosslinking ms! Please! Anyone! Because it looks like Wednesday is going to be watching YouTube videos about skyline with a lot of coffee.

Rip the bird app; hello it’s replacement. I’m Jaime, I adore roller derby and Mass Spectrometry.