James R Evans
@jamesrevans.bsky.social
Postdoctoral research fellow at UCL Queen Square Institute of Neurology and the Francis Crick Institute. Former musician.
How do immune and genetic drivers shape vulnerability in #ParkinsonsDisease? 🧠 Discovery Fellows M. Elizabeth Deerhake, James Evans, Amandine Even, Alexandra Kazanova, and Indrani Poddar are linking inflammation, genomics, and systemic factors to disease progression ⬇️ 🔗 bit.ly/3P9uqCM
TDP-43 loss of function drives aberrant splicing in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.04.673943v1
Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease. www.biorxiv.org/content/10.1... Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Parkinson's disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late...
biorxiv.org
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.08.25.671921v1