Other huge collaborative effort out too- T brucei VSG diversity in chronic cattle infections Led by Steve Larcombe and @keithrmatthews.bsky.social, with @goldrieve.bsky.social, @scotomorph.bsky.social, @rmc9z.bsky.social, Liam Morrison @roslininstitute.bsky.social etc www.biorxiv.org/content/10.6...

Restricted expression site use and extreme genome diversification drives trypanosome antigenic variation in chronic bovine infections

Trypanosoma brucei exploits an extreme form of antigenic variation to escape the mammalian immune response. This involves the progressive expression of antigenically distinct variant surface glycoprot...

biorxiv.org

Out now on biorxiv ... again T congolense VSG control ≠ T brucei. So much work by @scotomorph.bsky.social @marquescata.bsky.social @rmc9z.bsky.social @keithrmatthews.bsky.social Liam Morrison @roslininstitute.bsky.social and all our other fantastic collaborators www.biorxiv.org/content/10.6...

Trypanosoma congolense Variant Surface Glycoprotein gene expression occurs in the absence of monoallelic transcription control

Antigenic variation is a very widespread process for pathogen evasion of mammalian adaptive immunity, involving the continuous change of exposed antigens. In many single-celled pathogens, antigen expr...

biorxiv.org

One more time. Enjoy your swims but keep an eye.

Trish Greenhalgh@trishgreenhalgh.bsky.social · 2mo ago

Every summer I repost this article on how to spot drowning. Please read it and pass on. In the last few years I’ve had SIX messages from people who saved a kid’s life after clicking on the link from my feed. slate.com/technology/2...

This is such a fab account, still finding new info and pictures of the eruption

Mount St. Helens Archive@mountsthelens1980.bsky.social · 3mo ago

May 18, 1980 | 8:32 a.m. The ground shudders. A M5.1 quake hits beneath Mount St. Helens. Weakened critically, the north face bulge collapses outward. Within seconds, a pyroclastic density surge bursts through the disintegrating slope. The clock strikes zero.

Awesome work Joana and team! @fariatrypslab.bsky.social 👏

Department of Biology, University of York@biologyatyork.bsky.social · 4mo ago

(1/7) A new study from the Faria Lab in Nature Microbiology identifies a novel mechanism of spatially regulated RNA decay used to fine-tune the expression of virulence genes in T. brucei parasites. @fariatrypslab.bsky.social @ybri-uoy.bsky.social

Very happy to have contributed some confirmatory experiments to Jaclyn Smith and Monica Mugnier's excellent paper - out now @nature.com www.nature.com/articles/s41... @johnshopkinssph.bsky.social @rmc9z.bsky.social

Newest collaborative paper out now on biorxiv - new genome and VSG arrangements in T. congolense, excellent work by Marija! In the words of @scotomorph.bsky.social T. congolense ≠ T. brucei www.biorxiv.org/content/10.6... @rmc9z.bsky.social @keithrmatthews.bsky.social

1980s PCR machine in action!

Fun display in the kids room at Partick Library this week ... myths and mysterious creatures No @tetzoo.bsky.social book unfortunately

Ever since I learned about this study enrolling I have been eagerly awaiting the results. Researchers in Uganda took a centuries-old cultural practice mothers carrying babies on their backs in cloth wraps and turned it into a public health tool. You got to love it! www.nejm.org/doi/full/10....

Permethrin-Treated Baby Wraps for the Prevention of Malaria | NEJM

Malaria remains a major cause of childhood death in sub-Saharan Africa. We leveraged the traditional practice of mothers carrying children on their backs in cloth wraps to assess whether treating t...

nejm.org

Tangentially-related point. There are plenty of viral infections that, if caught *during pregnancy*, are associated w an increase of c ⅓ in the likelihood of having a child w autism. If you catch such a virus, & feel shite, what might you take for pain relief? www.sciencedirect.com/science/arti...

Maternal hospitalization with infection during pregnancy and risk of autism spectrum disorders

Animal models indicate that maternal infection during pregnancy can result in behavioral abnormalities and neuropathologies in offspring. We examined …

sciencedirect.com

Andrew R@excelpope.net · 11mo ago

Mrs R: "There was a woman on the ward today who didn't want to take paracetamol. We've had to explain that we're not giving it to her because she's got a fever and we want her to feel better, but because she's got a fever and if we don't get her temperature down then her baby is going to die."

This too

Amy Bradstreet@onbradstreetfarm.bsky.social · last yr.

Choose your swimwear colors carefully, too.

Thanks for the reminder @janemunday.bsky.social. Every summer, I repost this article DROWNING DOES NOT LOOK LIKE DROWNING. To date, I know of FOUR kids who were saved after someone who'd clicked on the link learnt how to spot actual drowning. Take time to read and pass on. slate.com/technology/2...

Drowning Doesn’t Look Like Drowning

Drowning is not the violent, splashing call for help that most people expect.

slate.com

@trishgreenhalgh.bsky.social Do you still have a link to that article on drowning that you normally share on twitter? I can't find it. Kids are doing 'drowning prevention week' at lessons, splashing around and shouting! Older one learning to use pool noodles to rescue a friend at least too.

I remember this from last year .. so interesting. Follow along with the eruption in real time

Mount St. Helens Archive@mountsthelens1980.bsky.social · last yr.

#MSH45 | 8:32 a.m. The ground shudders. A M5.1 quake hits beneath Mount St. Helens. The bulge collapses outward. Within seconds, a lateral blast surges through the disintegrating slope. 7 miles north, Gerry Martin describes what he sees—until the radio goes silent.

In our January issue: Do tissue-dwelling #trypanosomes sustain #transmission populations? authored by Stephen Larcombe @janemunday.bsky.social & @rmc9z.bsky.social highlighting Monica Mugnier & colleagues’ @nature.com article. #Antigenic #Variation #VSG #Differentiation www.cell.com/trends/paras...

Trends in Parasitology@cp-trendsparasitol.bsky.social · 2y ago

Our 2025 January issue bit.ly/2N9R8Es reviews #type2 #immunity in #gut #homeostasis & #Plasmodium transmission, #malaria elimination in Thailand, male & female #schistosome interactions, #placental malaria & #circumsporozoite protein-specific immunity, #community #ecology of #invasive #ticks, & more

#PlanetaryParade excitement is fantastic! #DoLookUp But I'm baffled by the media saying 25th Jan is a "once in a lifetime event" 🔭🧪 The awesome foursome Mars, Jupiter, Venus & Saturn have been on display for weeks + Neptune & Uranus if you have a telescope. We won't see Mercury until late Feb🤔 🧵1/6

Excellent work @goldrieve.bsky.social @keithrmatthews.bsky.social Congrats on getting the paper out www.nature.com/articles/s41...

Mechanisms of life cycle simplification in African trypanosomes - Nature Communications

African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory selected lines has identified a...

nature.com

Edinburgh Infectious Diseases@uoe-eid.bsky.social · 2y ago

Genes linked to deadly parasites’ spread beyond Africa identified. Parasites that cause the deadly illness known as sleeping sickness can spread beyond their native Africa as a result of mutations to key genes. @keithrmatthews.bsky.social @goldrieve.bsky.social Full article: shorturl.at/9jlGS

Our new OA spotlight paper is out ...are tissue reservoirs of Trypanosoma brucei the major site of antigenic variation, maintaining infections? With long-time collaborator Steve Larcombe and @rmc9z.bsky.social authors.elsevier.com/sd/article/S...

Are you a parasitologist in Scotland? Are you looking for ways to create a scientific community focused on ECRs in your area? In this TrendsTalk, we explain how we have done it for the Scottish Parasitology Partnership in Research, Innovation and Training (SPPIRIT)! www.cell.com/trends/paras...

New preprint from others in the lab - Mapping origins of DNA replication in Leishmania. Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss! www.biorxiv.org/content/10.1...

Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from...

biorxiv.org

Hello, and welcome to everyone! We run a weekly parasitology seminar series with recordings available, like here from last week from @robmoon.bsky.social! If you want to hear more, feel free to message me or @abhinay.bsky.social to be added to our mailing list t.co/Q0jpcxXPMI

Are you a researcher in #STEMM & currently caring for a child, another adult or your parent/partner/spouse? If so please take a few mins to share your experience w/ the 3Lauras @ Carers in STEMM Anonymous survey: qualtrics.manchester.ac.uk/jfe/form/SV_6s… Only 6d left to respond, please repost 🙏

As well as being accomplished vocalists, ravens are also grand masters of noughts and crosses...

Also if you live in Western Scotland and you think you’ve had a truly rubbish summer, you’d be right