I'm thrilled to share that the lab has received its first R01!! Together with Shuyi Ma and Christoph Grundner, we will be exploring how M tuberculosis gene networks regulate drug tolerance. More soon, but we will be recruiting postdocs and graduate students!

AI and synthetic biology are revolutionizing bioengineering. We're now in a time when these technologies are synergizing to create "living" drug delivery vehicles. @bashorlab.bsky.social and I discuss this at Advanced Drug Delivery Reviews: www.sciencedirect.com/science/arti...

Opportunities for artificial intelligence and synthetic biology in designing living drug delivery systems

Advances in artificial intelligence (AI) and synthetic biology are transforming biological research and biotechnology. These fields are for the first …

sciencedirect.com

Happy to share that my research center at Rutgers NJMS is hiring tenure-track faculty at all ranks! We are broadly interested in infectious disease research from experimental to computational. Please ask questions and join our community! jobs.rutgers.edu/postings/139...

Very happy to share some more good news. Our collaboration with Jeffrey Boyd's lab is now published at J Inorganic Biochemistry! Here, Jeff found that iron limitation reprograms S. aureus metabolism towards fermentation. We're grateful to be part of this study. www.sciencedirect.com/science/arti...

Fermentative growth decreases the iron demand of Staphylococcus aureus

Iron (Fe) is an essential nutrient for S. aureus survivability and pathogenesis, but excess Fe can catalyze the formation of toxic oxygen radicals, em…

sciencedirect.com

Happy to share that our collaboration with Christina @stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project! www.pnas.org/doi/abs/10.1...

I am recruiting a Ph.D. student in microbial ecology, evolution, and systems biology for fall 2026. Please share! Details: qevomicrolab.org/Documents/Gr... Apply by October 1 here: forms.gle/38pPS1Ky84HB...

I'm pleased to share that the preprint for our collaboration study on MIS-C in pediatric COVID-19 patients is now available on medRxiv. In this study led by Marila Gennaro at Rutgers NJMS, we report that antibody repertories vary with clinical presentation of COVID-19 in children.

medRxivpreprint@medrxivpreprint.bsky.social · last yr.

Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection https://www.medrxiv.org/content/10.1101/2025.07.22.25331300v1

It's nearing the end of the summer and our undergrads have been presenting on their research at their respective summer research symposia. Terrific work by Jonah Simone at the Rutgers Health BMIHAI Symposium and Gianna Elie at the NJMS URSE Symposium!

I'm excited to share that we've received a NIBIB Trailblazer Award to advance our work on engineering therapeutic macrophages! Grateful for our team and excited to launch this collaboration with the Caleb @bashorlab.bsky.social at Rice!

Many thanks to ScienceNews.dk for highlighting our work!

Stressed bacteria develop antibiotic resistance more easily

When bacteria are under energy stress – burning more energy than they produce, it increases their chances of developing antibiotic resistance. A new study offers new insight into how antibiotic...

sciencenews.dk

Thank you @njmicrobe.bsky.social for this really nice writeup about our work!

Theobald Smith Society@njmicrobe.bsky.social · last yr.

Bacteria under energy stress evolve antibiotic resistance faster. New work from Jason Yang’s lab, Rutgers shows how ATP imbalance drives mutagenesis, ROS production, and persistence. A big leap in understanding AMR. go.njmicrobe.org/Fs4R5J #AMR #Microbiology #JasonYang #Rutgers #AntibioticResistance

A study in Nature Communications shows that constitutive hydrolysis of ATP and NADH, or ‘bioenergetic stress,’ potentiates the evolution of antibiotic resistance and persistence in E. coli. #medsky 🧪

Bioenergetic stress potentiates antimicrobial resistance and persistence - Nature Communications

The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species formation. Here, Li et al. show that constitutive hydrolysis of ATP and NADH (or ‘bioenergetic stress’) potentiates the evolution of antibiotic resistance and persistence in E. coli.

go.nature.com

@rutgersu.bsky.social published a very nice article about our work! www.rutgers.edu/news/rutgers... @njms-mdphd.bsky.social

Rutgers Health Research Identifies New Trigger Accelerating Antibiotic Resistance

New Jersey Medical School study finds metabolic stress drives antibiotic tolerance and speeds resistance.

rutgers.edu

I'm thrilled to share the newest paper from the Yang Lab! Ever wonder how bacterial metabolism affects antibiotic resistance #AMR? In this study, Barry Li, a former MD/PhD student in the lab, took on this question using a systems and #synthetic_biology approach. 1/n www.nature.com/articles/s41...

Bioenergetic stress potentiates antimicrobial resistance and persistence - Nature Communications

The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species formation. Here, Li et al. show that constitutive hydrolysis...

nature.com

Honored to receive this year's Young Investigator Award from our local ASM branch!

Theobald Smith Society@njmicrobe.bsky.social · last yr.

Congrats to Dr. Jason Yang, winner of the 2025 TSS Young Investigator Award! His work at Rutgers uses machine learning & systems biology to tackle AMR, TB & more. A rising leader in biomedical science. Read more here: wix.to/tL2l4fi #Leadership #Microbiology #Innovation #SystemsBiology #Rutgers

Yang Lab had a terrific time at Rutgers' Biomedical Health Informatics and Artificial Intelligence Symposium yesterday. Great jobs by Yiqi Yan, Oliver Gu, and Reuven Rosen who presented on their work!

Our undergraduate machine learning maestro Edson Petry gave a terrific research presentation this afternoon at the Rutgers Pathways for Junior Scientists Research Program! #Rutgers #NJMS

I'm so proud of my technician Lia Goodwin who presented a poster at her first conference at the CSHL Systems Immunology meeting yesterday!

Ever wonder how Mycobacterium #tuberculosis deals with stressful environments? I'm pleased to share that in a second piece of good news this week, our recent work in collaboration with Shuyi Ma (Seattle Children's) was published at Frontiers in Tuberculosis. 1/n www.frontiersin.org/journals/tub...

Frontiers | Predicting fitness in Mycobacterium tuberculosis with transcriptional regulatory network-informed interpretable machine learning

frontiersin.org

I am thrilled to share that our rock star MD/PhD student Barry Li successfully defended his PhD today entitled "Bioenergetic stress potentiates antimicrobial resistance evolution and persistence"! Barry is our first student to finish his PhD and I am so incredibly proud of him!

Pleased to share our papers are highlighted by the editors at Nature Communications: www.nature.com/collections/...

Microbiology and infectious diseases

This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...

nature.com

Rutgers published a very nice story on our recent work! www.rutgers.edu/news/researc...

Researchers Reveal Why a Key Tuberculosis Drug Works Against Resistant Strains

Rutgers Health study uncovers vulnerabilities in drug-resistant TB, offering hope for improved treatments.

rutgers.edu

Thrilled to share that we have 2 new manuscripts on drug-resistant #tuberculosis out at @NatureComms ! In this pair of manuscripts, we investigated changes in #mtb physiology associated with INH resistance. 1/n www.nature.com/articles/s41... www.nature.com/articles/s41...

Catalase activity deficiency sensitizes multidrug-resistant Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline - Nature Communications

Multidrug-resistant (MDR) tuberculosis threatens global control of tuberculosis disease. Here, the authors investigate mechanisms underlying the collateral sensitivity of MDR Mycobacterium tuberculosi...

nature.com