John Matson

@jbmatson.bsky.social

Professor of Chemistry at Virginia Tech, interested in organic, macromolecular, and supramolecular chemistry. Secretary of IUPAC Subcommittee on Polymer Terminology; ACS POLY Division Treasurer. Posts are my own.

Congrats to Anna Steele and Isaac Addo on this paper. Our first of many on poly(olefin sulfones) is now live in @polymerchem.rsc.org

Matson Lab@matsonlabvt.bsky.social · 8mo ago

Matson lab is ready to flaunt another brand new publication! Congrats to Isaac and Anna on their brand new paper on poly(olefin sulfone)s in @polymerchem.rsc.org !! We thank NSF Division of Chemistry and semiconductor research corporation for the funding! pubs.rsc.org/en/content/a...

Brace yourself World! We have another new publication in hand! Congratulations to our dearest Dr. Zhao, Bushra, Ishani and Clark for their paper in ACS Material Letters @pubs.acs.org in collaboration with Bitton group from @bengurionuni.bsky.social and Yin Wang! Hurray🥳 pubs.acs.org/doi/10.1021/...

Cellular Uptake and Antioxidant Activity of H2S-Releasing Tetrapeptide Supramolecular Polymer Nanostructures

Self-assembled peptide–H2S donor conjugates (PHDCs) can deliver hydrogen sulfide in vitro and in vivo, yet the link between the supramolecular nanostructure morphology and cellular uptake remains unclear. Herein, we designed constitutionally isomeric PHDCs that self-assembled in aqueous solution into either nanoribbons, nanofibers, or nanobelts with various dimensions based on cryogenic transmission electron microscopy and small-angle X-ray scattering. Nile-red loaded PHDCs showed morphology-dependent uptake by H9C2 cells based on fluorescence microscopy combined with flow cytometry and confocal imaging, where narrow, helically twisted nanoribbons entered most efficiently. All PHDCs released H2S at similar rates, but the amount of H2S released inside the cells depended on the internalization ability of each PHDC. Consistent with these results, the narrow twisted nanoribbons afforded the greatest protection against H2O2-induced oxidative stress. Overall, this study highlights how subtle molecular-level changes can influence nanostructure formation in supramolecular assemblies and ultimately affect their cellular uptake and biological activities.

pubs.acs.org

We are delighted to welcome Spencer Kearns over the summer as a part of VT's REU program. Spencer is senior at VT majoring in BS Chem. We look forward to experience some exciting research in polysaccharides from him soon!

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