Matson Lab

@matsonlabvt.bsky.social

The Matson Lab at Virginia Tech Dept of Chemistry develops small molecules and materials for biology, medicine, and sustainability using tools from organic, polymer, and supramolecular chemistry.

We are a bit delayed in making the post but super proud and excited to share that our very own Anna Steele had received the Graduate Student Doctoral Assistantship award for Spring 2026! Congratulations Anna!!🥳🥳

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Cheers to the newest PhD candidate of the Matson Lab ! Congratulations to Aritra on passing his candidacy exams today afternoon! We look forward to his exciting works on oil demulsifying polymers with RAFT polymerization in the coming years!

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Spring ACS has come once again! With it comes updates on VT Chem at the conference! For Sunday's schedule: John Matson 8:25; International B - Marriott Marquis. Amanda Morris 11:15 - 11:40; A401GWCC Nadim Mahmud 4:40; M304 - Marriot Marquis.

Congrats to PhD #18, Dr. Clark Vu a.k.a. THE NIGHT OWL of the Matson Lab! It was an absolute delight to have you on our Bottlebrush team all these years. To the one stop BUDDY for everyone in the lab, we shall miss you and wish you all the very best for the future!🥳🥳

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Brace yourself World! We have another new publication in hand! Congratulations to our dearest Dr. Zhao, Bushra, Ishani and Clark for their paper in ACS Material Letters @pubs.acs.org in collaboration with Bitton group from @bengurionuni.bsky.social and Yin Wang! Hurray🥳 pubs.acs.org/doi/10.1021/...

Cellular Uptake and Antioxidant Activity of H2S-Releasing Tetrapeptide Supramolecular Polymer Nanostructures

Self-assembled peptide–H2S donor conjugates (PHDCs) can deliver hydrogen sulfide in vitro and in vivo, yet the link between the supramolecular nanostructure morphology and cellular uptake remains unclear. Herein, we designed constitutionally isomeric PHDCs that self-assembled in aqueous solution into either nanoribbons, nanofibers, or nanobelts with various dimensions based on cryogenic transmission electron microscopy and small-angle X-ray scattering. Nile-red loaded PHDCs showed morphology-dependent uptake by H9C2 cells based on fluorescence microscopy combined with flow cytometry and confocal imaging, where narrow, helically twisted nanoribbons entered most efficiently. All PHDCs released H2S at similar rates, but the amount of H2S released inside the cells depended on the internalization ability of each PHDC. Consistent with these results, the narrow twisted nanoribbons afforded the greatest protection against H2O2-induced oxidative stress. Overall, this study highlights how subtle molecular-level changes can influence nanostructure formation in supramolecular assemblies and ultimately affect their cellular uptake and biological activities.

pubs.acs.org

We are delighted to welcome Spencer Kearns over the summer as a part of VT's REU program. Spencer is senior at VT majoring in BS Chem. We look forward to experience some exciting research in polysaccharides from him soon!

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Congratulations to our second PhD candidate of the season! Udita passed her candidacy exam yesterday! We look forward to some exciting work from her on reactive sulfur species in near future!🥳🥳

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Congratulations to Matson Lab PhD candidate Isaac Addo for winning the Best Poster award at the Virginia Tech Macromolecular Innovation Institute's Technical Conference & Review 2025 last week! We are super proud of you Isaac!

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Cheers to the first PhD candidate of the Matson Lab for this season! Congratulations to Isaac on passing his candidacy exams yesterday! We look forward to his exciting works on POS polymers in the coming years!

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