“A country that under-invests in basic research does not stop benefiting from science. It becomes more reliant on other systems to take the early risks, generate the foundational knowledge and shape the next generation of…advances.” Over reliance is bad #Canada 🧪 theconversation.com/to-lead-in-g...

To lead in global innovation, Canada must prioritize basic science

Canada must decide what kind of country it wants to be: One that generates new scientific knowledge, or one that waits for other nations’ discoveries.

theconversation.com

"In this study, we present a genome-scale map of genetic interactions in the human haploid cell line HAP1, based on CRISPR-based perturbation of ∼4 million gene pairs. The resulting network comprises ∼89,000 high-confidence gene-gene interactions" doi.org/10.1016/j.ce...

Scientists at Canadian institutions have long punched well above our weight despite low and stagnant funding. Spending a billion dollars on external recruitment while science here is starving is exactly what Harper got wrong about supporting research excellence in Canada.

Mark Carney@mark-carney.bsky.social · 8mo ago

Canada’s new government is investing big to attract world-class talent in science and technology — and become an innovation powerhouse.

It is a nice way to end the week: our improved RAB GTPase BioID map now online! www.nature.com/articles/s42... We hope it will be useful to the community, and we're happy to share any reagents!

A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments

Communications Biology - Proximity labeling proteomics of RAB GTPases identifies an array of neighboring RAB proteins. Functional validation studies reveal links between RAB25 and DENND6A, or...

nature.com

Here is a very nice preprint from the Lussier lab! www.biorxiv.org/content/10.1...

RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B

The endolysosomal system is a dynamic intracellular network essential for cargo degradation, recycling and spatial compartmentalization. Precise coordination of endosome maturation and positioning is ...

biorxiv.org

Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years. Contact me if you are interested. www.nature.com/naturecareer...

Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461

Canada Excellence Research Chairs (CERC)

nature.com

We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...

Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375

The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).

nature.com

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

Two new lab manuscripts describing new insight into VPS29’s role in Retromer vs Retriever, and the identification of a non-classical Commander pathway in melanosome biogenesis. Both with @BrettCollins.bsky.social lab. www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1...

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibition.

The endosomal-lysosomal network is a hub of organelles that orchestrate the dynamic sorting of hundreds of integral membrane proteins to maintain cellular homeostasis. VPS29 is a central conductor of ...

biorxiv.org

Postdoc opening in my lab, joint with Prof Lee-Hwa Tai, to develop genomics, transcriptomcis and immunology pipelines for cancer immunotherapy. Details here or DM me: mqvlab.com/positions/

Looking for a high qualtiy scientific meeting being held in Canada this year? The 12th Canadian Developmental Biology Meeting (Regional SDB @socdevbio.bsky.social meeting) is happening May 25-28 in Kelowna BC. Registration is now open! www.sdbonline.org/meeting?Reso...

Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪

Now that science bsky is a thing, I would like to remind you that my Department has two faculty openings in cancer biology/-omics/immunology. Come work with me - We have a very supportive environment, big dreams, and life in Sherbrooke is so good! shorturl.at/EcnMZ @futurepislack.bsky.social

We developed #RESI (Resolution Enhancement by Sequential Imaging), a #DNAPAINT based single-molecule method that achieves 1-2 Å localization precision and sub-nm resolution using a conventional fluorescence microscope and standard reagents. 1/13

For my first post on Bluesky, here is our BioID map of RAB GTPases! It was a collective effort from many in the lab initiated by Benoît, Raphaëlle, and Dominique and followed up extensively by Véronique! I'll happily share the associated data if anyone is interested. www.biorxiv.org/content/10.1...

A Proximity MAP of RAB GTPases

RAB GTPases are the most abundant family of small GTPases and regulate multiple aspects of membrane trafficking events, from cargo sorting to vesicle budding, transport, docking, and fusion. To regula...

biorxiv.org