Jeff Martell
@jeffmartell.bsky.social
Assistant Professor, UW-Madison Chemistry. Group website: http://martellgroup.chem.wisc.edu.
Check out this awesome paper from @neugmonicaelena.bsky.social on a new family of nickel pincer enzymes! www.nature.com/articles/s41...
Discovery and characterization of a nickel enzyme family that catalyses intermolecular hydride shuttling - Nature Chemistry
There is limited understanding of nickel-catalysed chemistry in nature. Now a bioinformatic pipeline reveals a structurally distinct family of nickel pincer nucleotide-dependent enzymes. Nickel pincer...
nature.com
The final version of our new paper is out now - and open access @acs.org Central Science!! Such a fun collaboration! pubs.acs.org/doi/10.1021/...
Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling
Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...
pubs.acs.org
Jeff Martell@jeffmartell.bsky.social · 11mo agoExcited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr... 1/n
Check out our review on DNA-scaffolded catalysis! This link provides free full text access until the end of 2025: authors.elsevier.com/a/1m43W9CpcY.... Big thanks to co-authors @edwardpimentel.bsky.social , Ashley Ogorek, @ethan-hartman-125.bsky.social , and Caleb Cox
Congratulations @genlichem.bsky.social and Xiao! Very clever probe design.
Chris Chang@christhechang.bsky.social · 11mo agoHappy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...
My work assessing the effect of preorganization on dihydrazide activity is out in @jacs.acspublications.org. We find that dihydrazides with flexible tethers can replicate much of the catalytic activity of complex dihydrazides with preorganized foldamer scaffolds. #Chemsky doi.org/10.1021/jacs...
Bifunctional Catalysis of Aldol Reactions by Foldamer Dihydrazides: Assessment of Conformational Preorganization
We previously reported that molecules containing two cyclic hydrazide units connected by a polymethylene linker could catalyze aldol condensations via a bifunctional mechanism. One hydrazide apparentl...
doi.org
Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr... 1/n
Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling
Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...
chemrxiv.org
Really proud of Riley's preprint on a new class of chiral Lewis acid photocatalysts. This project benefitted from a terrific collab with @chemguyeli.bsky.social chemrxiv.org/engage/chemr...
Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr... New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale. 1/n
DNA-Scaffolded Ultrahigh-Throughput Reaction Screening
Discovering and optimizing reactions is central to synthetic chemistry. However, chemical reactions are traditionally screened using relatively low-throughput methods, prohibiting exploration of diver...
chemrxiv.org
Despite ~20 years in/around #chembio research, I went to my first Bioorganic GRC this week. This community is amazing and so supportive. I feel energized (and tired, lol) and find myself rooting for the next generation of chemical biologists. Sooooo much awesome science - We can’t/won’t be stopped!
