Hey Chemists, we’re hiring, come join us! See the original post below, happy to answer questions. Charleston is a beautiful place to live, and we have great facilities, students, and colleagues! #chemsky @chemjobber.bsky.social

Mike Giuliano@drmikeg83.bsky.social · 3w ago

Come join us! The CofC Dept. of Chemistry and Biochemistry is looking for a tenure-track assistant prof. in organic chemistry. We’re great place for undergraduate research, with superb facilities, great instrumentation for a PUI, and oustanding students! #chemsky jobs.cofc.edu/postings/18244

This piece really resonated with me - so often I've wished I could go back and assure my younger self that things will (mostly) work out: www.science.org/content/arti...

To my younger self, the overwhelmed new professor: You will make it

How this scientist navigated the tough decisions and personal strain of starting a lab

science.org

Congrats to Dr. Andrew Johns, the 7th PhD from our lab! He gave a great talk describing his project on using photo-crosslinking to identify tyrosine phosphatase substrates. His work dropped on bioRxiv yesterday: bsky.app/profile/nsha...

Neel Shah@nshahlab.bsky.social · 4w ago

Excited to share this new preprint, led by graduate student Andrew Johns! We used amber suppression to install photocrosslinkers in PTP1B to enable identification of new substrates. Our method detects localization- and stimulation-dependent changes in substrate scope. www.biorxiv.org/content/10.6...

Excited to share this new preprint, led by graduate student Andrew Johns! We used amber suppression to install photocrosslinkers in PTP1B to enable identification of new substrates. Our method detects localization- and stimulation-dependent changes in substrate scope. www.biorxiv.org/content/10.6...

In situ identification of substrates of the protein tyrosine phosphatase PTP1B using site-specific photo-crosslinking

Protein tyrosine phosphorylation is critical for cellular function, and aberrant phosphorylation is tied to a wide range of human diseases. Identifying the substrates of protein tyrosine phosphatases,...

biorxiv.org

Wow, this looks awesome and will be a great resource to anyone studying protein-protein interactions, SLiMs, and cell signaling! Excited to dig into this. Congrats to everyone involved!

Ylva Ivarsson@ivarssonlab.bsky.social · last mo.

Excited to share our preprint introducing ASHI: the Atlas of SLiM-mediated Human protein-protein Interactions. By screening 800+ domains against the human intrinsically disordered regions, we map 20,000 SLiM-mediated interactions. Many thanks to everyone involved! www.biorxiv.org/content/10.6...

“The whole point of AI tools is that I no longer need to retain information in my biological memory. My biological memory is for other things now. Important things. Like my Netflix password” 😂 inpreparation.substack.com/p/opinion-i-...

Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

inpreparation.substack.com

Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...

Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack

nytimes.com

I love New York.

Congrats, Weeks lab! Very enabling platform and a cool study!

Amy Weeks@amyweeks.bsky.social · 2mo ago

Now online @pnas.org: We developed a simple, scalable, and accessible platform for deep profiling of phosphoeraser specificity using human phosphoproteome-derived peptide libraries (PhosPropels!) 🧪👩‍🔬https://www.pnas.org/doi/10.1073/pnas.2523183123

New crew, new photo, still awesome to work with!

Happy to introduce PhD #6, aka Dr. Minhee Lee! He gave a fantastic talk today and did a great job defending his dissertation!

Are you interested in understanding protein dynamics and allostery in biomedically relevant "loopy" enzymes? We are looking for postdocs to join our group at GT for both applied and method development work. If you are interested, please email me your CV, cover letter, and details of 2-3 referees.

⌛ Don’t miss the June 1 registration deadline for #ProteinPhosSRC! This conference brings together scientists from around the world to share new discoveries in protein phosphorylation, disease mechanisms, and therapeutic development. Register now! buff.ly/YxSgh5Y

We are hiring! This is a joint Lab Assistant position with @phosphotig.bsky.social ‘s lab. If you are organized and creative, enjoy learning new things, and if working with two great teams of scientists sounds appealing, please apply! unc.peopleadmin.com/postings/319...

My department is open to hosting a Starting Grant lab. If you are eligible and want to do biochemistry broadly defined (we like everything, from biophysics to systems biology!) consider applying. My department is the best and Zurich is pretty good too! www.nature.com/naturecareer...

Assistant professor for ERC Starting Grant in Biochemistry - Zurich (CH) job with University of Zurich (UZH) | 12859194

Assistant professor for ERC Starting Grant in Biochemistry (non-tenure track)

nature.com

Happy to share this paper from our lab, with @jlmcfalinefigueroa.bsky.social’s group, out in its final form at Science Advances! Big congrats to lead authors Anne van Vlimmeren and Ross Giglio! www.science.org/doi/10.1126/...

Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants

RNA sequencing of cells expressing SHP2 disease mutants shows how changes to enzyme structure cause different cellular outcomes.

science.org

Neel Shah@nshahlab.bsky.social · last yr.

Check out our latest preprint, from Anne van Vlimmeren in my group and Ross Giglio in @jlmcfalinefigueroa.bsky.social's lab. We used single-cell transcriptomics, biochemistry, and structural analysis, to reveal how mechanistically distinct SHP2 disease mutations yield different cellular states.

New research from the @jlmcfalinefigueroa.bsky.social and @nshahlab.bsky.social groups, recently published in Science Advances, uncovers novel mechanisms by which SHP2 mutations disrupt cellular processes. This work may help pave the way toward future therapies for patients > bit.ly/4nGsVZm

Excited to share our lab's latest preprint, led by graduate student Minhee Lee, with contributions from former undergrad Zijing Wang and grad student Andrew Johns! We show that substrate specificity information coupled with AF3 models can be used to design selective tyrosine kinase inhibitors.

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 3mo ago

Substrate-derived peptides for selective covalent inhibition of protein tyrosine kinases https://www.biorxiv.org/content/10.64898/2026.05.11.724146v1

Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!

Posttranslational modifications remodel proteome-wide ligandability - Nature Chemical Biology

A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...

nature.com

Chris Parker@chrisgparker.bsky.social · last yr.

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Passionate about ubiquitin biology, its mechanistic underpinnings and therapeutic exploitation? We are looking for a PhD student or postdoc to join our team. Applications and informal inquiries welcome! www.mpinat.mpg.de/19-26?c=3895...

PhD student or Postdoc (f/m/d)- Understanding and manipulating ubiquitin ligase specificities -

The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for the position as PhD student or Postdoc (f/m/d) – Understanding and manipulating ubiquitin ligase specifi...

mpinat.mpg.de

Excited that our paper on enzymatic bromination of peptides is now online at ACS Chemical Biology! Led by Haley Bridge, we showed that the flavin-dependent halogenase RebH and its variants can be used for late-stage chemoenzymatic diversification of bioactive peptides: pubs.acs.org/doi/10.1021/...

Enzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki–Miyaura Coupling

Flavin-dependent halogenases (FDHs) provide a biocatalytic approach for the site-selective halogenation of aromatic compounds, but their use in late-stage functionalization of peptides has remained li...

pubs.acs.org

🏆 2026 Protein Society Award Winners Celebrating the scientists shaping the future of protein science 👏 🎤 Hear from this year’s award winners live at #PS40 in Boston this July 🔗 Learn more + register: proteinsociety.org/annual-symposium #TheProteinSociety

Check out my new piece in @sciencepolitics.bsky.social ! “We’re Training Scientists for a World That No Longer Exists” sciencepolitics.org/2026/03/18/w...

We’re Training Scientists for a World That No Longer Exists - Science Politics

Science can help address pressing challenges, but only if we train scientists to communicate in the places people actually form beliefs.

sciencepolitics.org

The first publication while at UCLA! We developed and utilized generative AI protein design methods for targeting the disordered and highly charged C-terminus of RAS to generate RAS isoform specific binders/inhibitors: www.sciencedirect.com/science/arti...

De novo design of Ras isoform selective binders

The four major isoforms encoded by RAS proto-oncogenes are differentially associated with cancer, but there are few isoform-specific binding reagents …

sciencedirect.com

I am REALLY excited to share this manuscript from my group now on bioarxiv. Here we used the OAA lectin scaffold to ask can lectins be evolved to have specific interactions for defined glycan structures . www.biorxiv.org/content/10.6...

🚨 Our new paper is out! 🙌 Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs. We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs. www.cell.com/chem/fulltex... 1/4

A modular genetic code expansion approach to site-specific lysine acylations

A modular strategy combining genetic code expansion with a selective amide bond-forming reaction enables the site-specific installation of lysine acylations on folded proteins. Acylboronates react sel...

cell.com

Excited to share our new Perspective in @natchembio.nature.com with @Yang_J_lab. How do we move from isolated cysteine modifications to a systems-level understanding of redox signaling? We outline a unified chemical framework for decoding the cysteine redoxome. Read here: t.co/6XY1FCdtN6

So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore

Roland Dunbrack 🏳️‍🌈@rolanddunbrack.bsky.social · 5mo ago

Great work from post-doctoral fellow @joanzone.bsky.social: New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation. doi.org/10.64898/202...

BLEAK. Bleak. I’d been paying attention to Columbia selling out its governance to the Trump admin, not so much its stance on AI. www.columbiaspectator.com/opinion/2026...