Researchers (led by @jeroenpasterkamp.bsky.social) demonstrate how sparse genetic labeling enables comprehensive reconstruction of individual dopamine neurons in mice; Subtypes exhibit distinct developmental & adult morphologies, as well as responses to axon degeneration www.cell.com/neuron/fullt...

A catch-up on recent group publications! First, a perspective on the state of the field on study of microglial dysfunction in C9orf72 #ALS and #FTD in iPSCs from @bvahsen.bsky.social together with @jeroenpasterkamp.bsky.social. journals.lww.com/nrronline/ci...

📃Presentation of EP briefing by neuroscientists @ellyhol.bsky.social & @jeroenpasterkamp.bsky.social Strengthening Brain Health: Policy Recommendations to Tackle the Rising Burden of Neurological Diseases www.europarl.europa.eu/cmsdata/3028...

Exciting opportunity to learn about #humanbrainmodels and #singlecelltechnology! July 13-17 2026 we for the first time will offer the Utrecht Summer School titled "Advanced human brain models in the single-cell era" for master and PhD students. Apply now: utrechtsummerschool.nl/courses/life...

Great thesis defense by Astrid van der Geest today on unveiling early pathologies in #ALS using #organoids. @umcutrecht.bsky.social

#NHDN25 was a great meeting with many excellent talks and posters!

Jozefien Goethals@joziegoethals.bsky.social · 10mo ago

Professor @jeroenpasterkamp.bsky.social just presented his work at #NHND25 on modelling neurodegenerative diseases in a dish, showing new avenues in using organoids models in C9-ALS 🧫

Presentations at the annual meeting of our NWO Gravitation Consortium BRAINSCAPES with Nik Heijmink presenting our recent genetic sparse labeling approach in the dopamine midbrain and Pavol ZELINA sharing insights into HT screening for neurodegenerative disease using human in vitro models.

In our new study in BRAIN, we use a brain organoid model in which microglia innately develop to further dissect the mechanisms that cause changes in microglia in C9ORF72-ALS and show that PU.1 can help to reverse these pathogenic phenotypes. #GoALS academic.oup.com/brain/advanc...

PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids

Accumulating evidence implicates non-neuronal cells in ALS pathogenesis. Using patient-derived cerebral organoids, Ljubikj et al. reveal reduced microglial

academic.oup.com

The Amsterdam City Swim was again a very special event that raised 1.7 million Euro for research into ALS last Sunday. I had the privilege to join with both both my son and daughter, which made it even more special. Thanks to everyone for sponsoring us. Looking forward to ACS 2026!

Thanks to the @neurochemistry.org (ISN) for allowing me to organize a symposium on ‘Molecular mechanisms of motor neuron disease’ at the 2025 ISN-ASN meeting in NYC. Great talks by Christine Vande Velde, Stefania Corti and Sami Barmada.

Check out this paper by Werner Dykstra in which we study the effects of GFAP mutations on brain organoid development. doi.org/10.1002/glia...

Mutations in GFAP Alter Early Lineage Commitment of Organoids

Mutations in GFAP alter lineage commitment of organoids. The severity of this commitment defect is dependent on the method of embryoid body formation. GFAP is expressed in iPSCs and during early st...

doi.org

OUT NOW!! We developed a brain organoid slice protocol to study and manipulate human microglia in a 3D brain-like environment. Great work by Marta Cañizares Luna, Mayte Mars and Channa Jakobs. www.sciencedirect.com/science/arti...

Protocol for generating and using human iPSC-derived microglia-containing air-liquid-interface cortical organoid cultures

Here, we present a protocol for generating long-term microglia-containing air-liquid-interface cortical organoid (MG-ALI-CO) cultures. This approach m…

sciencedirect.com

Extremely proud of Özge Düdükcü, who defended her thesis on GABAergic neuron diversity and development on May 1st in Utrecht!

This week we organized the 2nd edition of the DDSSCC (Development of the dopaminergic system - from stem cells to circuits) meeting in Crete! Great science and a fantastic atmosphere. Excellent talk by Eljo van Battum from the lab and a poster prize for Oxana Garritsen! See you all for DDSSCC 2028!

Out now: Our meeting report of the 2024 European Society of Toxicologic Pathology (ESTP) meeting session 'Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery'. doi.org/10.1177/0192...

Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery - Laura Fusaro, Dinesh S. Bangari, R. Jeroen Pasterkamp, Javier Fernández-Ruiz, Sameh A. Youssef, Alok ...

The fourth session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress brought together lectures focused on the use of in vitro and in vivo mo...

doi.org

Check out our review on the role of guidance proteins in neuron migration by Eljo van Battum and Marleen van den Munkhof. www.sciencedirect.com/science/arti...

Novel insights into the regulation of neuron migration by axon guidance proteins

Neural circuit development requires precisely coordinated guidance of migrating neurons to their targets within the nervous system. A diverse array of…

sciencedirect.com

Talking at the 1st edition of New Horizons in Neurodegeneration, a two-day conference in Leuven, Belgium: www.vibconferences.be/events/new-h.... This event will bring together leading experts to explore the complexities of Alzheimer’s, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).

New Horizons in Neurodegeneration

9-10 October 2025, Leuven, Belgium Organized in partnership with Cell Press

vibconferences.be

Had the pleasure of visiting the Institute of Psychiatry, Psychology & Neuroscience at King’s College London yesterday! Big thanks to Jemeen Sreedharan.

Op 25-4 presenteren we dit boek. In het Flevoparkbad in Amsterdam. Met Femke Heemskerk; @jeroenpasterkamp.bsky.social de zwemmende burgemeester van Heiloo @spinvis.bsky.social en anderen. Wees welkom!

Registration for the 10th edition of our Summerschool on 'Neural circuit development and plasticity' is open! July 7-11 in Utrecht for MSc and PhD students, and others who are interested. Spread the news! @umcutrecht.bsky.social @utrechtuniversity.bsky.social

Echt heel cool! Bij de limited edition van mijn nieuwe boek 📘: De mooiste 50 meter buitenbaden van Nederland 🇳🇱 sealen in oplage van 2️⃣0️⃣0️⃣ de Spinvis-singel Ik wil alleen maar zwemmen op vinyl bij. Alle info via buitenbaden.com kan je eventueel een exemplaar reserveren. @dolfjansen.bsky.social

Impressive documentary on ALS: www.linkedin.com/posts/als-ce...

ALS Centrum Nederland on LinkedIn: 🎥 Kijktip: ALS Centrum in Driedubbel Gezond   Vandaag is de eerste…

🎥 Kijktip: ALS Centrum in Driedubbel Gezond   Vandaag is de eerste aflevering van het nieuwe EO-programma Driedubbel Gezond, die geheel in het teken staat van…

linkedin.com

Excellent thesis defense today by Xandor Spijkers on microfluidics systems to model the neuromuscular system in collaboration with Nienke Wevers and Paul Vulto at MIMETAS! @umcutrecht.bsky.social

Check out our newest collaborative work on the pleiotropy and penetrance of ATXN-2 CAG repeat expansions in ALS. @umcutrecht.bsky.social www.nature.com/articles/s41...

An observational study of pleiotropy and penetrance of amyotrophic lateral sclerosis associated with CAG-repeat expansion of ATXN2 - European Journal of Human Genetics

European Journal of Human Genetics - An observational study of pleiotropy and penetrance of amyotrophic lateral sclerosis associated with CAG-repeat expansion of ATXN2

nature.com

Looking forward to speaking at 'New Horizons in Neurodegeneration', October 9-10, Leuven, Belgium. www.vibconferences.be/events/new-h...

New Horizons in Neurodegeneration

9-10 October 2025, Leuven, Belgium Organized in partnership with Cell Press

vibconferences.be

We are organising the AXON meeting in Rotterdam, September 17-19, 2025. Registration is open. See you on the ssRotterdam! axon2025.com

Ik kijk uit naar het mooie boek over buitenbaden!

Jim Jansen@jimjansen.bsky.social · 2y ago

Soms komen verschillende werelden samen. Met @jeroenpasterkamp.bsky.social en het @umcutrecht.bsky.social werken goed samen en organiseren we tweejaarlijks een brein-event. Maar Jeroen zwemt ook. En best hard. Ik sprak hem voor De mooiste 50 meter buitenbaden van Nederland. Foto: Bram Belloni

We are again organising our annual Utrecht Summerschool on 'Neural circuit development & plasticity' for (inter)national senior MSc and PhD students, July 7-11 2025! Application is open and we hope to see you all in Utrecht this summer: utrechtsummerschool.nl/courses/life...

Check out our updated lab website: www.jeroenpasterkamplab.com. Great team studying developing and diseased neural circuits!

Interested in neuronal disease modelling? Consider joining our summer school in July. It will be fun👇

Dirk Schubert@schubertneuro.bsky.social · 2y ago

Join our "Neurological Disease Modeling" at Radboud Summer School 2025 to learn innovative research techniques. 🗓️ June 30-July 4, 2025 👉 Apply: ru.nl/en/education... Watch out: #FENS/IBRO-PERC stipends available Apply here👉 loom.ly/yJqQ0rY #Neuroscience #FENS