Jerome Ezan
@jezan.bsky.social
INSERM researcher at Neurocentre Magendie / @neurobordeaux.bsky.social / @univbordeaux.bsky.social Mount Sinai, NYC @sinaiirm.bsky.social alumnus Cell and developmental biology are my favorite! "As above, so below"
I'm thrilled to share our contribution in a collaborative work with Laure Strochlic ‘s team, that is now published in the Journal of Clinical Investigation! www.jci.org/articles/vie...
JCI - MuSK cysteine-rich domain antibodies are pathogenic in a mouse model of autoimmune myasthenia gravis
jci.org
Thrilled to host the #Syncell Inc #Microscoop event on March 21st in #Bordeaux! Anybody interested in the prospects of #spatialproteomics is more than welcome! 📍 **Location:** Amphi Broca Nouvelle Aquitaine, Bordeaux 📅 **When :** March 21st, 2:00pm-3:30pm
Kinases play a role in many diseases, making them prime targets for therapeutic intervention. Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity. Read the full article: academic.oup.com/bioinformati... @alussana.bsky.social @epetsalaki.bsky.social
PhosX: data-driven kinase activity inference from phosphoproteomics experiments
AbstractSummary. The inference of kinase activity from phosphoproteomics data can point to causal mechanisms driving signalling processes and potential dru
academic.oup.com
The Martin lab has an open postdoc position at the interface of #cytoskeleton and #condensate biology, in a fantastic research community! If interested, do not hesitate to contact us: mocel.unige.ch/research-gro... Please RT!
Cool paper (and great resource). I’m especially keen the disconnect between mRNA and protein levels in adult tissues! Pay attention #devbiol, it’ll be the same in embryonic tissues. www.cell.com/cell/fulltex...
A Quantitative Proteome Map of the Human Body
Proteomics analysis across human tissues from the GTeX resource reveals insight into tissue-specific pathways and phenotypes arising from genetic diseases.
cell.com
Nikolai Slavov@slavov-n.bsky.social · 2y ago5,562 proteins were found to have tissue-specific enrichment across 32 human tissues. The majority of them (3,088) are enriched at the protein but not RNA level. The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
A neuronal Rube Goldberg machine 🤯 Wnt from surrounding cells is internalized via clathrin-coated pits at dendritic branch points before triggering microtubule nucleation at the surface of endosomes. Great work from Melissa Rolls' lab in @plosbiology.org: journals.plos.org/plosbiology/...
