I’m happy to share our new paper (with @mbartos.bsky.social) now out in Nature Neuroscience: "The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations" Download it @ rdcu.be/famDE More below 🧵

Congratulations to @olechsylte.bsky.social on receiving a Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship! 🎉 Ole will investigate how the brain transforms spatial knowledge into goal-directed actions.

We are hiring postdocs to work on representational drift and network dynamics (ERC-funded project using calcium imaging /neuropixels). If you are interested, please get in touch! Here is the link to the official job ad: www.uni-saarland.de/fileadmin/up...

Excited to share that our IN-CODE interneuron research is featured in NANO, the science program from ZDF! Big thanks to Max Lebsanft and @mbartos.bsky.social for bringing neuroscience to a wider audience! www.zdf.de/video/magazi...

Rätselhaftes Gehirn: Zwei Zelltypen arbeiten zusammen gegen das Vergessen

NANO vom 8. Dezember: Im Gehirn entscheiden Prinzipalzellen und hemmende Nervenzellen gemeinsam über unsere Erinnerungen. Versagt ihr Zusammenspiel, steht das ganze System auf der Kippe.

zdf.de

Happy and honoured to receive an ERC Consolidator Grant for our research on representational drift! Postdocs interested to join this journey (ideally with prior experience in in vivo ephys/imaging): please get in touch, there will be openings soon…

Fantastic symposium on circuit function last week here at CIPMM. Thanks to our guests Kristina Lippmann, Magdalene Schlesiger, Fiona Muellner and @juliaveit.bsky.social for sharing their latest on synaptic function, interneuron & pyramidal cell networks and long-range communication.

See below for the latest results from the lab! Led by @susannebabl.bsky.social with support from @dfg.de and @for5159.bsky.social

Susanne Babl@susannebabl.bsky.social · last yr.

The last part of my PhD with @torfisigurdsson.bsky.social is now published in @plosbiology.org journals.plos.org/plosbiology/... We looked at the interaction of the hippocampus and prefrontal cortex during spatial working memory when mice were navigating a T-maze, using ephys and optogenetics 🧠🐭

Engaging poster session at the IN-Code retreat. Thanks to our SAB members and all researchers of the CRC for their interest! All students did a great job presenting their projects. @mbartos.bsky.social @uni-freiburg.de @biologyunifreiburg.bsky.social

New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah! www.cell.com/cell-reports...

Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons

Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities. Muysers et al. show that mPFC neurons fall into distinct functional classes that differ in terms of their spatial tu...

cell.com

Representational drift in CA1? We find hidden features of stability in the internal geometry of population activity, which might help to maintain a stable downstream readout. Now preprinted thanks to a great collaboration w/ @olechsylte.bsky.social , @antjekilias.bsky.social and Marlene Bartos. 👇

Ole Christian Sylte@olechsylte.bsky.social · last yr.

Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics. New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇

Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y ago

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice https://www.biorxiv.org/content/10.1101/2025.01.16.633322v1

I am honoured to join Saarland University as Professor of Physiology in February 2025. My department will focus on the network mechanisms of learning, with particular interest in synaptic function & computations of large neuronal populations. We are hiring, so feel free to get in touch!