A truly groundbreaking study showcasing the transformative potential of human glial chimeric brain models for in vivo AAV evolution. Combining human glia-selective capsids with glymphatic delivery represents a landmark advance toward precise CNS gene therapy!

Nature Biotechnology@natbiotech.nature.com · 2mo ago

Efficient targeting of human glial progenitor cells in vivo with engineered AAV vectors and glymphatic delivery - @urmed.bsky.social @ucph.bsky.social www.nature.com/articles/s41...

Well said on the role of somatic mutations in myeloid cells in Alzheimer's disease! (www.cell.com/trends/molec... The CSF2RB A455D variant from our study is also a promising example. More studies using chimeric brain models with human microglia carrying somatic mutations are needed.

Can grafted microglia be harnessed for neuronal replacement? Motivated by their unique properties for cell-based therapies, we explored the direct conversion of human microglia into neurons. Excited to share our new study on bioRxiv.

All models have limitations. Animal models remain indispensable for neuroscience research. Meanwhile, chimeric brain models provide unique opportunities to study human neural cells with advanced maturation and functional integration in an in vivo brain environment. www.cell.com/cell-metabol...

New approach methodologies: Don’t throw the baby out with the bathwater

The NIH has recently called for expanding use of new approach methodologies (NAMs) to reduce use of animals in research. Arany discusses the need not to forget the irreplaceable aspects of animal rese...

cell.com

Thrilled to share our new study published in @cp-cellreports.bsky.social, led by Mengmeng Jin, Ziyuan Ma, and Haiwei Zhang. Grateful for a wonderful collaboration with Dr. Steve Goldman, a pioneer in chimeric brain models and a leading expert in glial biology. www.cell.com/cell-reports...

Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions

Jin et al. develop chimeric mouse brains containing human microglia, astroglia, oligodendroglia, and neurons, enabling direct interrogation of human neuron-glia interactions in vivo. These models reca...

cell.com

Thank you so much for highlighting our work!

Gan Lab@liganlab.bsky.social · 9mo ago

New study from Jiang group gives clues to Down syndrome patients' resilience to AD: a DS-linked myeloid mutation (CSF2RB A455D) protects engrafted human microglia against tau by suppressing harmful IFN signaling, boosting phagocytosis, & reducing microglial senescence www.nature.com/articles/s41...

An idea we started in 2019 is now published in @natneuro.nature.com! Excited to share our new study: rdcu.be/eRvdA Congrats to Mengmeng Jin and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!

Thrilled to share our review just published in @cp-neuron.bsky.social ! 🎉 Big shoutout to Ava, Mengmeng, and our entire team! authors.elsevier.com/a/1k-uh3BtfH...

Hopefully a little inspiration for our trainees...this was led by an amazing postdoc at UPitt..Dr. Jean Liou

UCI MIND@ucimind.bsky.social · last yr.

www.newsweek.com/woman-down-s... @lizhead.bsky.social

Advancements in 3D models for studying human iPSC-microglia: Insights ... www.sciencedirect.com/science/arti...

Advancements in 3D models for studying human iPSC-microglia: Insights into neurodevelopment and neurological disorders

Microglia are immune cells of the central nervous system, playing a vital role in brain development, homeostasis, and disease. When these cells become…

sciencedirect.com

Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks academic.oup.com/brain/advanc...

Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks

Graham et al. show that Alzheimer's disease-associated genetic variants are enriched in gene networks expressed by microglia and oligodendrocytes during ag

academic.oup.com

www.nature.com/articles/s41...

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease - Nature Neuroscience

This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...

nature.com