Macrophage-mediated refinement of the dural lymphatic regulates social behavior: Neuron www.cell.com/neuron/fullt...
John Lukens
@lukensjohnr.bsky.social
Neuroimmunologist studying MS, autism, Alzheimer's disease, and brain injury at the University of Virginia. Father of two. Fan of Philly sports and US soccer. www.lukenslab.com
Gateways for myeloid cell entry into the central nervous system: Neuron www.cell.com/neuron/fullt...
JCI - Western diet induces iron-dependent enteric neurodegeneration via ferroptosis www.jci.org/articles/vie...
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell www.cell.com/cell/fulltex...
SARM1 executes neuronal parthanatos and promotes excitotoxic cell death www.cell.com/neuron/fullt...
Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol www.nature.com/articles/s41...
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin @cp-immunity.bsky.social www.cell.com/immunity/ful...
Neuron-derived mitochondrial DNA (mtDNA) activates microglia via the Z-DNA binding protein 1 (ZBP1)-mediated pathway in mild traumatic brain injury www.pnas.org/doi/abs/10.1...
Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar: www.cell.com/neuron/fullt... 🦋💐 @cp-neuron.bsky.social
Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar
Over the last three decades, dogma-breaking studies have refuted the brain’s assumed immune isolation. Echoing Ramón y Cajal metaphor of neurons as “butterflies,” Schwartz proposes viewing the brain a...
cell.com
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration www.nature.com/articles/s41...
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration - Nature Neuroscience
ALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and neurodegeneration...
nature.com
Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition @cp-neuron.bsky.social www.cell.com/neuron/fullt...
The Genotoxic Stress Sensor ZBP1 Drives Tauopathy and Neurodegeneration www.mdpi.com/2073-4409/15...
A transcriptomic microglia taxonomy across mouse and human pathologies www.nature.com/articles/s41...
Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures: @cellpress.bsky.social www.cell.com/cell/fulltex...
From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus www.science.org/doi/10.1126/...
From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus
Chronic pain often evolves into depression and anxiety, yet mechanisms linking sensory distress to affective dysfunction remain unclear. Integrating human neuroimaging from the UK Biobank with a roden...
science.org
A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation www.science.org/doi/10.1126/...
A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation
Psychological stress is believed to exacerbate dermatitis, yet the neurobiological mechanisms linking stress to immune processes remain elusive. We identified a subset of prodynorphin-positive (Pdyn+)...
science.org
Brain’s protective barrier stays leaky for years after playing contact sports www.nature.com/articles/d41...
Brain’s protective barrier stays leaky for years after playing contact sports
Damage to the blood-brain barrier is linked to immune changes and cognitive decline.
nature.com
Brain’s protective barrier stays leaky for years after playing contact sports www.nature.com/articles/d41...
Brain’s protective barrier stays leaky for years after playing contact sports
Damage to the blood-brain barrier is linked to immune changes and cognitive decline.
nature.com
6-Hydroxydopamine promotes antitumor immunity through macrophage remodeling beyond sympathetic ablation: Neuron www.cell.com/neuron/fullt...
Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation www.nature.com/articles/s41...
Persistent microglial activation following neonatal CMV infection mediates neurodegeneration www.science.org/doi/10.1126/...
Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis www.nature.com/articles/s41...
Resident tissue macrophages maintain intraocular pressure homeostasis. @cp-immunity.bsky.social www.cell.com/immunity/ful...
Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs: @cellpress.bsky.social www.cell.com/cell/fulltex...
JCI - Disruption of CSF-1 receptor-mediated metal ion homeostasis in the murine brain promotes neurodegenerative disease www.jci.org/articles/vie...
New work from the lab on how sickness reduces appetite. Turns out, it’s complicated :) We focused on a single inflammatory cytokine, IL-1b, and even that reduces appetite via multiple mechanism. Thanks to Nik Hayes for leading and sticking with this project and to everyone else who contributed!
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 5mo agoIL-1β engages distinct peripheral sensory circuits to suppress feeding across time https://www.biorxiv.org/content/10.64898/2026.02.23.707454v1
Central neurons encode interleukin-1β signals and mediate stress-induced inflammation url: rupress.org/jem/article/...
