Here’s an interesting story for #teammassspec. Liraglutide went generic in December 2024 and we have been developing methods for impurity characterization but we kept seeing an unusual modification with a +12 Da shift. A little digging revealed that others had noticed that the n-terminal histidine..

Dinner at Locust Point Steamers in Baltimore prior to #ASMS2025. Highly recommended for any seafood lovers coming to the conference!

Catch-44

David Corn@davidcorn.bsky.social · last yr.

4002: A Space Odyssey.

This is perfect. Absolutely perfect.

Cory Booker on the floor of the senate reconciling quantum mechanics and relativity.

Dr. Jessie Christiansen@aussiastronomer.bsky.social · last yr.

Cory Booker is on the floor of the Senate explaining the IAU definition of a planet.

I am going to #USHUPO2025 next week. I’m super excited to connect with some old friends and have some conversations with everyone about all the latest tech! If you see me there, please tap me on the shoulder and say hello!

Rounded Turn SLIM Design for High-Resolution Ion Mobility Mass Spectrometry Analysis of Small Molecules #AC pubs.acs.org/doi/10.1021/...

Rounded Turn SLIM Design for High-Resolution Ion Mobility Mass Spectrometry Analysis of Small Molecules

Various rounded turn designs in Structures for Lossless Ion Manipulation (SLIM) were explored via ion trajectory simulations. The optimized design was integrated into a SLIM ion mobility (IM) system coupled with a time-of-flight (TOF) mass spectrometer (MS) for further experimental investigation. The SLIM-TOF IM-MS system was assessed for IM resolution and ion transmission efficiency across a wide m/z range using various RF frequencies and buffer gas combinations. High ion transmission efficiency and high resolution ion mobility (HRIM) separation were achieved for Agilent tune mix ions through a ∼12.8 m serpentine separation path in both nitrogen and helium. In helium, ion transmission for low m/z ions was enhanced at higher RF trapping frequency, enabling the detection of ions with m/z below 50 and all 17 amino acids from a standard mixture. Lossless ion transmission was observed for glycine (m/z 76) in both passthrough and HRIM modes. HRIM resolution was benchmarked using L-isoleucine, L-leucine, and various other isobaric and isomeric metabolites with m/z values of 60–89. This work demonstrates a rounded turn SLIM design that enables HRIM measurements for small molecule analytes, with a particular focus on metabolomics, where IM offers a means to enhance the speed, robustness, and specificity of analytical workflows.

pubs.acs.org

I saw there is an update to Factorio that I am trying to resist buying as I know I will put hundreds of hours into it that I don’t have.

We don't need more remakes of old movies. We need more MUPPETS remakes of old movies.

I feel like there is a higher lever of consternation than normal here. Then I realized everyone is talking about college football and now it makes more sense.

I like to believe that @sciex.bsky.social designed their QQQ optics to look like some futuristic Sci-Fi weapon used by some sketchy aliens operating on the far reaches of the galaxy.

#teammassspec This one gave a satisfying pop.

#teammassspec oops.

Another horror scene for #teammassspec. Found some pictures from my time in service. This was an old QQQ that had sat idle for many months. At some point the vacuum system failed and due to a firmware fault, the HV did not disengage and sat energized for an unknown time.

Horror show Thursday for #teammassspec. I’ve been holding on to this picture for a long time. Clean your source.

Put a TIMS in front of an 18T FTMS? Why not!

#TeamMassSpec recent newcomers you'll want to follow: @jespervolsen.bsky.social @kmechtler.bsky.social @vadim-demichev.bsky.social @nesvilab.bsky.social @nlkproteomics.bsky.social

#teammassspec. Many moons ago I was a postdoc for Ruedi Aebersold as a biochemist with some mass spec experience. One of the projects that consumed me for a couple of years was a way to make internal standard peptides easier to make and more affordable.

Question for #teammassspec here. Are internal standard peptides like AQUA or QConCat still in use commonly? I haven’t worked in this space for a number of years but worked on a project that never saw the light of day that I may just open source the concept here.

I have enjoyed reading @dereklowe.bsky.social articles for years but his “things I won’t work with” pieces hold a special terrifying spot in my heart. There are many scientists much braver than myself to explore such malodorous, energetic, or toxic compounds.

Occurs to me that folks here might not be aware of the slightly terrifying series of @dereklowe.bsky.social's "Things I Won't Work With" chemistry blog posts. Both www.science.org/content/blog... and www.science.org/content/blog... are highlights, but the whole series is full of "oh heeeelll no"

Things I Won't Work With: Dioxygen Difluoride

science.org

I know a block list of this size probably puts a bit of extra burden on Twitter servers and I consider that my tiny middle finger towards Elon for ruining Twitter. I hope this app can somehow restore the amazing interactions I had with amazing scientists on Twitter in the past.

As of this posting, my block list is approximately 650,000. My goal is to hit 1 million and quite frankly see how far I can go before they just shut down my account.

Eventually Twitter couldn’t keep up with the block list and when you ask for the block list, the number gets stuck at 250k. I eventually found a third party tool that could more accurately estimate the size of the block list.

Over the last several months as blue checks have proliferated, I began to get more aggressive in my blocking. Eventually it morphed into challenge to see how many accounts I could block and I began using various tools like Chrome Blue Blocker with some coding tweaks to start crawling for blue checks

As Twitter continues to decline I began blocking blue checks in an attempt to try and keep my feed clean. I always enjoyed the scientific discourse on Twitter in the past and had a carefully curated list of groups and people I followed in the past.

I thought I should finally make a post here. Greetings to anyone who can see this. I’m trying to gradually make an escape from Twitter.