Missed SCP2026 - here are the published and preprinted highlights - day 1 - proteomicsnews.blogspot.com/2026/07/prep... and day 2 proteomicsnews.blogspot.com/2026/07/prep...

Preprinted data featured in Day 1 at SCP2026!

I've got to start a new page of notes for day 2 or OneNote will definitely crash. Obviously there is a lot of unpublished data here I don'...

proteomicsnews.blogspot.com

Great to be at #BSPR2026 in Hinxton this week, supporting the UK's key proteomics gathering. On Monday, conference conversations continued at our Peaks & Pints event - it's been a pleasure connecting with so many of you. If you're still here today, stop by - we'd love to hear what you're working on.

A drop in the number of international students coming to the UK cost the country nearly £3 billion, according to new estimates https://www.timeshighereducation.com/news/fall-international-student-numbers-cost-uk-ps29-billion

New preprint: Cell-type-resolved spatial proteogenomics, matched genome AND proteome of the same cells. The trick: the flowthrough we normally discard after loading peptides onto an Evotip contains genomic DNA at 85–95% yield. One tip, two molecular layers. www.biorxiv.org/content/10.6...

Cell-type-resolved spatial proteogenomics from matched genome and proteome of the same cells

The genome and proteome of the same cells are rarely measured together, which is especially consequential in cancer, where somatic mutations vary across clones and drive disease. We show that a single...

biorxiv.org

As usually, the Single-Cell Proteomics Conference aims to maximize accessibility. Thus, #SCP2026 will enable virtual attendance via Zoom. It's free but requires registration at single-cell.net Only presentations by speakers who consent to Zoom broadcast will be included in the virtual program.

Switzerland and the UK making the most of their participation in the EU research funding initiatives with Switzerland tied with Germany for the largest number of grants in life science.

European Research Council (ERC)@erc.europa.eu · last mo.

The results of the Advanced Grants 2025 are here! Out of 3,329 applicants, 319 leading researchers have been awarded an ERC Advanced Grant. Congratulations to all! 🎉 Curious to know more ? 👉 buff.ly/uiU9x5K #ERCAdG #FrontierResearch

A decade ago, the money wasted on poor antibodies was estimated to be US $800 million / year. Global research antibody spending is ~$4-6B/year now vs $1.6B in 2015. What is your estimate for money wasted on poor antibodies in 2026 ?

What an amazing story.❤️

Cervical cancer deaths fall to zero in young women given HPV vaccine

A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.

bbc.co.uk

New preprint out! We benchmarked SCP workflows across instruments, software and library strategies. We compare DIA-software, search parameters, quantification precision and quant reliability across 3 cell types: large A549, medium RKO, and the very challenging ex-vivo peripheral blood neutrophils.

The Single Cell Proteomic blueprint, navigating instrumentation platforms, software tools and high-load libraries in neutrophils, RKO and A549 cells

Mass spectrometry-based single cell proteomics (SCP) is rapidly emerging as a powerful approach for biological research, with applications extending beyond in-vitro cancer cell lines. Recent advances ...

biorxiv.org

Celebrating IRR research, innovation and impact. Our 2026 symposium showcased our fantastic research talent. Congratulations to Flash Talk Prize winner Ellen McGregor, poster prize winner Jenny Riches and poster prize runners-up, AJ Boyland, Kellie Horan and Skye Jolly. 🎉 🔬 🏆https://edin.ac/4fBVzsP

Luke Gamon, Asst Prof at @ucph.bsky.social, built a spatial proteomics workflow from standard lab equipment: PCR tubes, centrifuges, basic plastics. When a single Aurora column can handle 2,500 injections and still perform, that kind of longevity changes what's feasible. Learn more: bit.ly/4ulX2XL

I’m delighted to announce that my first paper has been published in eLIFE! In this paper, we explore how B cells alter their metabolism to fuel changes in cell growth and proliferation following stimulation with the toll-like receptor 4 (TLR4) ligand lipopolysaccharide.

Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation

B cell activation and antibody class switching requires coordinated metabolic rewiring, with essential roles for amino acid transport, cholesterol metabolism, and prenylation in driving proliferation ...

elifesciences.org

This is REALLY bad of Thermo. They've got caught, and their statement (in thread) smacks of a complete misunderstanding of of what they've done and disregard for their customers. What would happen if I submitted a paper with an image that had been "adjusted for presentaton purposes". Quite.

Reese Richardson@reeserichardson.bsky.social · 2mo ago

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

QuantUMS is the default method in our DIA-NN software. www.nature.com/articles/s41...

Accurate quantification in proteomics with QuantUMS - Nature Biotechnology

QuantUMS implements uncertainty estimation for protein quantification in mass spectrometry.

nature.com

Companies selling faulty products by accident recall them and reimburse the customers. Some cost, some (temporary) loss in prestige perhaps. No one goes to jail. This is not the case here. This is more akin to the Theranos or VW emission scandals. And people did go to jail for these.

Reese Richardson@reeserichardson.bsky.social · 3mo ago

@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...

Congratulations to Nikolai Slavov, recipient of the 2026 ASMS Biemann Medal! This award recognizes significant early-career achievement and highlights emerging leaders shaping the future of #massspectrometry. #TeamMassSpec

BSPR 2026 is on 13th-15th July. Early bird discount til 15th May, register here: www.bspr.org/annual-meeti... We have exciting sessions covering: Comput. Proteomics/AI Native/Structural proteomics Clinical proteomics Population proteomics/non-MS proteomics single-cell/low input/spatial proteomics.

Matrix Science will be attending BSPR2026 in Cambridge, UK, on 13-15 July. Come chat with us about the latest developments with Mascot. Abstract and early bird registration deadline is 15 May, so it's best to book your place soon! #proteomics #massspec #BSPR2026

British Society for Proteome Research@ukbspr.bsky.social · 4mo ago

Early bird registration is still open! Don't forget to register at: www.bspr.org/annual-meeti...

If you are annotating SDRFs from public proteomics data or your own submission, and you have access to #Claude; #gemini #OpenAI #Codex or ClaudeCode, you can use #SDRF-skills; really simple github.com/bigbio/sdrf-...

GitHub - bigbio/sdrf-skills: Agentic plugins to annotate SDRF using Claude; Codex; Cursor; Gemini

Agentic plugins to annotate SDRF using Claude; Codex; Cursor; Gemini - bigbio/sdrf-skills

github.com

🚀 SDRF Validator is LIVE! Check it out 👉 www.ebi.ac.uk/pride/servic... With #SDRF v1.1.0, we’ve rolled out tailored templates for different experiment types - from Single Cell proteomics #SCP to Crosslinking, & more. The new validator + web interface makes it easy to catch issues before submission.

New Publication: Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma @edinuni-irr.bsky.social @cruk-si.bsky.social @edinunineuro.bsky.social @pranvera.bsky.social @ajbrenes.com www.nature.com/articles/s41...

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma - Nature Communications

Neutrophils infiltrate glioblastomas with the capacity to engage pro/anti tumoural responses. Here the authors developed proteomic workflows to stratify neutrophil heterogeneity by function. This work...

nature.com

for keen DIA-NN users, be aware that DIA-NN 2.5 has 5% FDR on by default!! not 1% like all previous versions. You have to change it manually every time.

MAJOR update for SCP Viz! github.com/OrsburnLab-P... - all the smart SCP code everyone hid on line 7,000 of their R package in a GUI with push buttons, lassos, and primary colors. Plus a special tab for peer reviewers who don't want to download 3TB of instrument .raw data. Live on the Pitt HPC now!

GitHub - OrsburnLab-Pitt/SCPViz: The new home of the SCP Viz program

The new home of the SCP Viz program. Contribute to OrsburnLab-Pitt/SCPViz development by creating an account on GitHub.

github.com

Hey #UKimmunomet26 attendees 👋 Come and say hello at the BSI stand! Chat with Laura Franklin (our Journals Manager) and Ellie Pearson (intern at the BSI) about our journals, how to submit your work, and the other opportunities we offer. We’d love to see you there!

I have to say the train ride down to #UKimmunomet26 is a beauty. Now looking forward to the next two days hearing about immunometabolism. Excited that there are even multiple neutrophil talks 😃

For those of you who, like me, were eagerly waiting for it, the cherry blossoms on the meadows are finally out #sakura #hanami

Excited to share our new @natcomms.nature.com study with the @garyrlewin.bsky.social lab and @amapruns.bsky.social. Using deep visual proteomics, we created the first neuronal subset-resolved proteomic map of sensory neurons with potential implications for pain treatment. go.nature.com/481nr4R

Deep visual proteomics uncovers nociceptor diversity and pain targets - Nature Communications

Sensory neuron subtypes are defined by transcriptomics, but their proteomic identities remain unclear. Here, authors show distinct protein signatures of electrophysiologically defined nociceptors and ...

go.nature.com

Assessing error control is fundamental in mass spectrometry-based proteomics. @bo-wen.bsky.social @maccoss.bsky.social @urikeich.bsky.social et al introduce a theoretical foundation for entrapment along with a method for more accurate evaluation of FDR control. www.nature.com/articles/s41...

Assessment of false discovery rate control in tandem mass spectrometry analysis using entrapment - Nature Methods

A theoretical foundation for entrapment methods is presented, along with a method that enables more accurate evaluation of false discovery rate (FDR) control in proteomics mass spectrometry analysis p...

nature.com

Cherry Blossoms 🌸 Sakura Season in Japan 🇯🇵

Senescence applied to neutrophils is just silly. None of them are dividing ... and thats how its meant to be...

Science News@scinews.bsky.social · 4mo ago

Targeting senescent-like neutrophils via selenium supplementation holds therapeutic promise to enhance immunotherapy efficacy in liver cancer. gut.bmj.com/content/earl...