Nascent chain folding status modulates ribosome dynamics and mRNA stability through the ribosome-associated chaperone Zuo1

Chang et al. show that co-translational protein misfolding feeds back to ribosomes, slowing translation elongation and triggering mRNA decay. The ribosome-associated chaperone Zuo1 mediates this respo...

cell.com

N4-Acetylcytidine enhances synthetic mRNA translation yield and fidelity - Nature

Different RNA modifications elicit different translation elongation rates for in vitro transcribed mRNAs that result in disparate translation outputs and fidelity, as shown here for N4-acetylcytidine ...

nature.com

A staunch voice in support of science

Jeff Coller, a pioneering RNA biologist, has spent the past year vehemently advocating for the lifesaving promise of research in the face of federal cuts

hub.jhu.edu

Opinion | We Need to Keep Funding Weird Science

Science turned a serendipitous finding about lizard venom into one of the most important drugs of the century, but that type of research is getting harder to do.

nyti.ms

Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack

nytimes.com

mRNA COVID-19 Vaccines: Science vs. Misinformation

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

rnajournal.cshlp.org

Defending Against the Next Bioweapon: the mRNA Imperative

Modern synthetic biology and AI represent both medicine’s greatest breakthrough and warfare’s most terrifying evolution. In this new landscape, where

warontherocks.com

World's First Patient Treated with Personalized CRISPR Gene Editing Therapy at Children’s Hospital of Philadelphia

Landmark study from CHOP and Penn Medicine showcases the power of customized gene editing therapy to treat patient with rare metabolic disease.

chop.edu

Protecting President Trump's Legacy and mRNA Research

Operation Warp Speed stands as one of President Trump's most transformative achievements—a bold demonstration of American leadership that launched a medical revolution and positioned America as

realclearhealth.com

A surprise bonus from COVID-19 vaccines: bolstering cancer treatment

Patients who got shots of mRNA before starting a type of cancer immunotherapy lived much longer

science.org

A surprise bonus from COVID-19 vaccines: bolstering cancer treatment

Patients who got shots of mRNA before starting a type of cancer immunotherapy lived much longer

science.org

WSJ Opinion: RFK Jr.’s Misguided War on mRNA

Review & Outlook: Robert F. Kennedy, Jr. is using Biden-era mistakes to tarnish a promising technology, and scientists are pushing back.

wsj.com

mRNA vaccines hold promise for many diseases. Now the tech is under fire

Researchers warn that halting federal contracts for mRNA vaccine research could weaken pandemic preparedness and slow medical advances.

sciencenews.org

Opinion | RFK Jr.’s Dangerous Attack on mRNA Research

Covid-era coercion and misinformation bred public distrust, but the vaccines did save countless lives.

wsj.com

Opinion | RFK Jr.’s Dangerous Attack on mRNA Research — The Wall Street Journal

Covid-era coercion and misinformation bred public distrust, but the vaccines did save countless lives.

apple.news

What Do mRNA Funding Cuts Mean For Future US Research?

RFK Jr. canceled nearly $500 million in mRNA vaccine research funding. Plus, the latest climate news, from flooding in Alaska to new EVs.

sciencefriday.com

mRNA technology could hold hope for fighting cancer, but future is in doubt under RFK Jr.

Federal funding cuts to mRNA technology research doesn't just impact COVID vaccines — experts say it could stall progress in treatment for cancers, rare disease and more.

cbsnews.com

Pulling the Plug on mRNA Vaccine Development Is 'Reckless,' Experts Say

Puts U.S. at a disadvantage as H5N1 pandemic threat looms

medpagetoday.com

Medical experts react to RFK Jr. canceling $500M in vaccines development projects

Robert F. Kennedy Jr. announced in a statement Tuesday that 22 projects, totaling $500 million, to develop vaccines using mRNA technology will be halted.

apnews.com

Pulling the Plug on mRNA Vaccine Development Is 'Reckless,' Experts Say

Puts U.S. at a disadvantage as H5N1 pandemic threat looms

medpagetoday.com

Health secretary RFK Jr. shuts door on U.S. investment in mRNA vaccine research

Vaccine experts and people steeped in pandemic preparedness expressed horror at the news that RFK Jr. has shut the door in U.S. investment in mRNA vaccine research.

statnews.com

Biochemical analysis of human eIF4E-DCP2 interaction: Implications for the relationship between translation initiation and decapping

All eukaryotic mRNAs bear a 7-methylguanosine cap on their 5’ end. The 5’ cap enables mRNA translation by binding directly to eIF4E; which further recruits other factors and the 40S ribosome. Addition...

dx.plos.org

How political attacks could crush the mRNA vaccine revolution

Drug makers are scrambling to navigate an ‘existential threat’ to a once-celebrated technology.

nature.com

How political attacks could crush the mRNA vaccine revolution

Drug makers are scrambling to navigate an ‘existential threat’ to a once-celebrated technology.

go.nature.com

How political attacks could crush the mRNA vaccine revolution

Drug makers are scrambling to navigate an ‘existential threat’ to a once-celebrated technology.

go.nature.com

How political attacks could crush the mRNA vaccine revolution

Drug makers are scrambling to navigate an ‘existential threat’ to a once-celebrated technology.

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