John “Jack” Flores, MD
@jmfloresmd.bsky.social
4th year MedPeds Infectious Diseases fellow at University of Chicago, ID lover of all ages. 🦠🧫🩺 Father of two 🧒 and one 🐶 Go Irish ☘️
Increased Reporting of Infants Born with Congenital Syphilis to a Local Department of Public Health: A Quality Improvement Project ✅ Just Accepted #IDSky
Increased Reporting of Infants Born with Congenital Syphilis to a Local Department of Public Health: A Quality Improvement Project
In this quality improvement project, we successfully improved the reporting of infants diagnosed with and treated for congenital syphilis with non-reactive
bit.ly
Increased Reporting of Infants Born with Congenital Syphilis to a Local Department of Public Health: A Quality Improvement Project url: academic.oup.com/ofid/article... Had a LOT of fun with this one. Made me rethink epi of CS and if we are under (or over?) identifying certain groups. #ID #IDsky
Validate User
academic.oup.com
My adult daughter Rachel works everyday, pays taxes, loves going to movies with her friends, and listens to awful (IMO) music. Our U.S. Dept HHS has lost all of its humanity, compassion, and intellectual curiosity
I feel like I’ve met a milestone for any infectious disease trainee or provider — contribute to a MMWR ✅ . Really interesting trending and observing unexpected findings of our CNS syphilis cohort in Chicago Illinois. www.cdc.gov/mmwr/volumes...
Notes from the Field: Neurosyphilis ...
This report describes neurosyphilis, ocular syphilis ...
cdc.gov
In the current political climate, many misunderstand/misrepresent NIH "indirect costs", which cover facility and administrative costs essential for research Here's a video that explains what F&A expenses cover, how they are determined, and why they are essential www.youtube.com/watch?v=NtqK...
Dear #medsky Together we can help patients understand the importance of vaccines. No matter your specialty, please start talking about vaccines at every visit. Love, #idsky www.cidrap.umn.edu/influenza-va...
Information, clinician advice may be key to boosting vaccines in older people
cidrap.umn.edu
Doxycycline postexposure prophylaxis for bacterial STIs: Prescribing patterns, use, short-term outcomes among 2083 patients in a Los Angeles Federally Qualified Health Care Program, and implications for widespread use. ✅ Just Accepted #IDSky
Doxycycline postexposure prophylaxis for bacterial STIs: Prescribing patterns, use, short-term outcomes among 2083 patients in a Los Angeles Federally Qualified Health Care Program, and implications for widespread use.
Rates of bacterial sexually transmitted infections (STIs) have risen dramatically over the past decades. Doxycycline postexposure prophylaxis (DP) is a novel intervention to prevent bacterial STIs. Recent randomized controlled clinical trials reported high DP efficacy at preventing syphilis and chlamydia in cisgender men who have sex with men (MSM) and transgender women.
buff.ly
Had a great time assembling this DoxyPEP review with @anuhazramd.bsky.social , one more step towards reducing STIs in high risk populations #IDSky trebuchet.public.springernature.app/get_content/...
trebuchet.public.springernature.app
Just publish paper evaluating effects of vaccination on long COVID risks in children/adolescents during Delta/Omicron periods We found vaccines strongly protected against long COVID-19, and the effect was almost wholly mediated by reduced infection risk www.sciencedirect.com/science/arti...
I ran @USAID health programs for the last 3 years. Trump’s 90 day Stop Work Order on foreign assistance does serious damage to the world and the US. Examples:🧵
This JAMA Clinical Guidelines Synopsis focuses on the recent CDC guidelines on use of doxycycline postexposure prophylaxis (doxyPEP) to prevent bacterial sexually transmitted infections. ja.ma/3WxWi3D #MedSky
as someone about to graduate ID fellowship, the NIH price freeze immediately prompted my “how does this affect my k23 application?” But today I realized I’m fortunate to always have clinical medicine to do, as opposed to many community workers and research workers fully dependent on NIH financing.
I had a lot of fun riding this one with @anuhazramd.bsky.social , definitely a topic with some controversy, but could be a pivotal move to help reduce the incidence of this (not so) “hidden” syphilis epidemic.
This JAMA Clinical Guidelines Synopsis focuses on the recent CDC guidelines on use of doxycycline postexposure prophylaxis (doxyPEP) to prevent bacterial sexually transmitted infections. https://ja.ma/41FWRvL
This JAMA Clinical Guidelines Synopsis focuses on the recent CDC guidelines on use of doxycycline postexposure prophylaxis (doxyPEP) to prevent bacterial sexually transmitted infections. https://ja.ma/41FWRvL
🔥The ADAPT-Sepsis RCT🔥 Daily PCT-guided protocol 🔽 total antibiotic duration & had noninferior all-cause mortality compared with standard care. No difference was found in total Abx duration between standard care & daily CRP-guided protocol CRP failure #idsky #EMIMCC jamanetwork.com/journals/jam...
Biomarker-Guided Antibiotic Duration for Patients With Suspected Sepsis
This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antib...
jamanetwork.com
Cool analysis restricted to women younger than 25 to isolate the impact of routine HPV vaccination in US women since June 2006. "HPV vaccination affected the sequential decline in #HPV infection prevalence, cervical cancer incidence, and cervical cancer mortality." #VaccinesSaveLives #IDSky
Cervical Cancer Mortality Among US Women Younger Than 25 Years
This study examines trends in cervical cancer mortality in US women aged younger than 25 years before and after the introduction of human papillomavirus vaccines.
jamanetwork.com
Find me a better intervention in medicine. #VaccinesSaveLives
Many infants and children who are infected with hepatitis B become chronic carriers. Since we have been vaccinating newborns since the 1990s, the number of new cases of hepatitis have decreased. (3/7)
Author Jason Zucker of Columbia University Irving Medical Center speaks with JAMA Deputy Editor Preeti Malani about the transmission, diagnosis, management, and prevention of mpox. Listen to the episode: https://ja.ma/48UlfeJ
The ID march of shorter treatment is ok continues, this time for bacteremia (not including S. aureus). FYI, E. coli, Klebsiella, Enterococcus, and CoNS made up > 70% of organisms. By pathogen breakdown of risk difference emphasizes applicability of these results for GN bacteremia.
BALANCE is out! 7 days of antibiotics non-inferior to 14 days for bacteremia (excluding S. aureus). this is a practice-changing study that should have huge impacts on antibiotic prescribing. i also can't say enough about the study team (esp. nick daneman). inspiring. www.nejm.org/doi/full/10....
I can't find African Scientists and researchers easily on here. As the second largest continent with 1.3 billion inhabitants our perspectives matter. I'm creating a starterpack to find folks, follow them and amplify them. If you are an African Scientist let me know below so I can add you. Thanks.
Fun QI study looking and reducing ID fellow burnout. Essentially having more Attending physician presence makes for happier fellows 😀 ir.library.louisville.edu/jwellness/vo...
The Effect of a Structural Wellness Intervention on ID Fellows and Faculty
Introduction: Physician burnout is prevalent amongst Infectious Diseases (ID) physicians and trainees in the United States. There is limited data assessing the impact of structural interventions in re...
ir.library.louisville.edu
Really great review for the ID trainee (and refresher for the ID provider) #IDSky @cidjournal.bsky.social academic.oup.com/cid/advance-...
Current and future strategies for the prevention and treatment of cytomegalovirus infections in transplantation
Abstract. Successful prevention and treatment of cytomegalovirus (CMV) infection remains a central focus of clinical care in solid organ and allogeneic hem
academic.oup.com
This was a fun one with @allisonbartlettmd.bsky.social taking a dive into the PHIS database. Seems to be significant differences in practices with congenital syphilis nationwide. Differences in outcomes though?? Future research awaits. #IDsky #Pediatricsky journals.lww.com/stdjournal/a...
Describing the Heterogeneity of Clinical Utilization of... : Sexually Transmitted Diseases
ilis cases mirrors the nationwide increase....
journals.lww.com
One of the more interesting pro/con articles I’ve read recently. As a medpeds ID fellow really fascinating to not only see differences in practice by age, but also geography. I’m curious thoughts of #IDSky #PedsSky academic.oup.com/jpids/articl...
Fluoroquinolone Prophylaxis in Children With Cancer: A Pro/Con Discussion
Abstract. There are conflicting recommendations on whether to use or not to use fluoroquinolone prophylaxis in pediatric oncology patients. An internationa
academic.oup.com
“RSV disease severity among hospitalized adults […] comparable to or possibly more than the severity of influenza and SARS-CoV-2” And < 50% w/ respiratory infection were tested. Much still to learn about this now vaccine-preventable illness. jamanetwork.com/journals/jam...
Burden of Respiratory Syncytial Virus–Associated Hospitalizations in US Adults
This cross-sectional study identifies hospitalizations, intensive care unit admissions, and in-hospital deaths associated with respiratory syncytial virus in US adults from 2016 through 2023.
jamanetwork.com