Antibiotic Steward 🅱️C🆔🅿️🌟
@absteward.bsky.social
Stay up-to-date in Infectious Diseases, Clinical Pharmacist, Antibiotics, #IDTwitter t✨p influencer #interstellar #dune 🌹❤️Misk #idsky #medsky #AMSsky #idxposts Bassam Ghanem,PharmD MS BCPS BCIDP
What's in a name? The story of Coccidioides begins with a medical trainee, a mistaken identity, and a discovery that changed medical mycology. More than a century later, that trainee would have a species named in his honor. And yes—there's a reason it's called "Valley fever." #IDsky
🔥🔥IDSA AMR Guidance 2026🔥🔥 🔺Notable Updates from the 2024 IDSA AMR Guidance Document 🔺Meropenem dosing update: individualized dosing approach (1–2 g IV q8h) with higher doses considered in selected clinical scenarios. #idsky www.idsociety.org/practice-gui...
🔥 Update 🔥 The IDSA AMR Guidance 2026 link is now back online. You can access the guidance through the original link below. I'll be sharing the Notable Updates from the 2024 IDSA AMR Guidance Document soon. #idsky
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · last wk.🔥🔥Just published 🔥🔥 IDSA AMR Guidance 2026 IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections 🔺ESBL , AmpC Enterobacterales 🔺CRE 🔺DTR P. aeruginosa 🔺CRAB 🔺Stenotrophomonas maltophilia #idsky www.idsociety.org/practice-gui...
🆕🔥🔴ISLEND-1 RCT Among persons with virologically suppressed HIV-1, once-weekly oral Islatravir–Lenacapavir was noninferior to once-daily oral bictegravir emtricitabine tenofovir alafenamide B/F/TAF in maintaining HIV viral load suppression #IDsky #hivsky www.nejm.org/doi/full/10....
Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment | NEJM
Once-daily, single-tablet regimens have transformed care for persons living with human immunodeficiency virus type 1 (HIV-1); however, challenges to adherence continue to limit effective treatment....
nejm.org
Yikes. Never have I treated something that probably doesn't need to be treated so aggressively. Or at least expensively.
Update: The original link appears to be temporarily unavailable. I'll share the updated official link once it's available. #idsky
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · last wk.🔥🔥Just published 🔥🔥 IDSA AMR Guidance 2026 IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections 🔺ESBL , AmpC Enterobacterales 🔺CRE 🔺DTR P. aeruginosa 🔺CRAB 🔺Stenotrophomonas maltophilia #idsky www.idsociety.org/practice-gui...
🔥🔥Just published 🔥🔥 IDSA AMR Guidance 2026 IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections 🔺ESBL , AmpC Enterobacterales 🔺CRE 🔺DTR P. aeruginosa 🔺CRAB 🔺Stenotrophomonas maltophilia #idsky www.idsociety.org/practice-gui...
Love seeing this data. Skip phenomenon is rare and usually occurs in the context of a clinical change. No need to repeat BCx again when already cleared....and we might be able to get away with a single set to detect clearance of SAB
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 3w agoStaphylococcus aureus bacteremia guidelines recommend obtaining FUBCs every 2-4 days until bacteremia clearance! 🆕💥💥🟢 cohort study: Routine serial follow-up blood cultures after a negative result within 48 hours of MSSA bacteremia: low yield, high cost #idsky academic.oup.com/cid/article/...
A thoughtful editorial Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia? #idsky academic.oup.com/cid/article-...
Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia?
Yonas Martin, Steven Tong; Skipping to conclusions: Is one negative follow-up blood culture sufficient in Staphylococcus aureus bacteremia?, Clinical Infec
academic.oup.com
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 3w agoStaphylococcus aureus bacteremia guidelines recommend obtaining FUBCs every 2-4 days until bacteremia clearance! 🆕💥💥🟢 cohort study: Routine serial follow-up blood cultures after a negative result within 48 hours of MSSA bacteremia: low yield, high cost #idsky academic.oup.com/cid/article/...
Staphylococcus aureus bacteremia guidelines recommend obtaining FUBCs every 2-4 days until bacteremia clearance! 🆕💥💥🟢 cohort study: Routine serial follow-up blood cultures after a negative result within 48 hours of MSSA bacteremia: low yield, high cost #idsky academic.oup.com/cid/article/...
Routine serial follow-up blood cultures after a negative result within 48 hours of methicillin-susceptible Staphylococcus aureus bacteremia: low yield, high cost
Early skip phenomenon in Staphylococcus aureus bacteremia is rare (3.1%) with a very low risk of missed persistent bacteremia (1%). A practical day-2 focus
academic.oup.com
🆕💥🟢Among 305 episodes with suspected infective endocarditis and valve strands the majority did not represent IE. Recurrence of IE due to the same microorganism within one year was significantly more frequent among episodes with IE compared to those without #idsky academic.oup.com/cid/article/...
Validate User
academic.oup.com
Aw🫰SNAP🫰 Cefazolin vs anti-staphylococcal PCN ⬇️⬇️⬇️
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 2mo ago🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....
If there were PK/PD issues with fosfo, the problem might arise not on early TOC, but on relapses of non-cystitis UTI. In this subanalysis of patients switched to oral in FOREST trial, more relapses were observed with fosfo for bacteremic E. coli UTI. academic.oup.com/jac/article/... #IDSky #UTIsky
Caveats: - FOREST was 100% bacteremic UTI - A lower dose of oral fosfo was used (3g/48h). - Definition of relapse was more strict, requiring a new isolation of E. coli with same phenotype. - Absolute risk difference still low (11%), so definitely an option to consider if no other options! #IDSky
How would you describe target trial emulation in two words only? #idsky
Wow! 🆕🔥🔴Multicenter OL NI RCT Oral fosfomycin (3 g once daily) was noninferior to continued intravenous therapy with carbapenems or BLBLIs when used as oral transition therapy for complicated UTIs caused by ESBL-producing Enterobacterales #IDSky #utisky academic.oup.com/cid/article-...
Fosfomycin as Oral Transition Therapy Versus Continued Intravenous β-Lactams for Complicated Urinary Tract Infections Caused by Extended-Spectrum β-Lactamase–Producing Enterobacterales: A Multicenter,...
Switching from intravenous antibiotics to oral fosfomycin was noninferior to continuing intravenous therapy for complicated urinary tract infections caused
academic.oup.com
🔥Just approved 🔥 The FDA has approved Utebzi (tebipenem pivoxil) tablets as the first oral carbapenem therapy for adults with complicated urinary tract infections, including pyelonephritis #idsky #EMIMCC www.fda.gov/drugs/news-e...
FDA approves first oral carbapenem therapy for complicated urinary tra
FDA approves first oral carbapenem therapy for complicated urinary tract infections
fda.gov
Anti-staphylococcal penicillins are now a historic curiosity. Cefazolin FTW 👏🏻👏🏻
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 2mo ago🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....
Well, it only took ‘em 2 years to get past Reviewer 2, but they did it & as we say in Scotland, ‘it’s Oot’! SNAP paper 1, available now. Congrats 2 Todd Lee, Steve Tong, Josh Davis & the rest. First dram of this bottle is in your honour! Slàinte!! #IDsky #SNAP #morelikePoocloxacillin
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 2mo ago🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....
🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....
Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia | NEJM
Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...
nejm.org
While some may view ARISE-FLUIDS as final blow to 30 mL/kg, a new cohort JAMA of 25k pts:initial administration of ≥30 mL/kg associated with lower 30d mortality among pts with hypoperfusion or intermediate lactate elevation w/o severe cardiac or kidney comorbidities. jamanetwork.com/journals/jam...
Comorbidities, Weight-Based Initial Fluid Resuscitation, and Sepsis Mortality
This cohort study evaluates whether administration of 30 mL/kg or more of fluid within 6 hours of hospital arrival is associated with reduced 30-day mortality in adults with community-onset sepsis.
jamanetwork.com
Important study of real-world use of rapid respiratory diagnostics. Encouragingly, pace INHALE, no signal to harm in the intervention group (indeed signal to benefit in those with panel-detectable organisms on culture).
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 2mo ago🆕💥🔴Multicenter retrospective study of ICU patients with pneumonia BIOFIRE® PN Panel implementation was associated with improved early antimicrobial de-escalation and appropriate therapy #idsky academic.oup.com/cid/article-...
🆕💥🔴Multicenter retrospective study of ICU patients with pneumonia BIOFIRE® PN Panel implementation was associated with improved early antimicrobial de-escalation and appropriate therapy #idsky academic.oup.com/cid/article-...
Clinical Impact of the BIOFIRE® FILMARRAY® Pneumonia Panel in the Veterans Affairs Healthcare System: A Difference-in-Differences Study
In this national, multicenter retrospective study of intensive care unit patients with pneumonia in Veterans Health Administration hospitals, BIOFIRE® PN P
academic.oup.com