Craig Smail wrote up a really nice Preview of @nikhilmilind.dev's paper where we try to explain why large effect variants tend to affect traits in the same direction on average, which we think about in terms of the non-linearity of gene dosage response curves. www.cell.com/cell-genomic...

Gene dosage differences and non-linear impacts on complex traits

Large differences in gene dosage are usually associated with opposite phenotypic effects but show a bias toward one direction in aggregate genome wide. Milind et al. suggest that this is explained by ...

cell.com

Presentations by folks from the Coop lab at #PEQG26 5pm Tues. James Kitchens @kitchensjn.bsky.social " Visualizing the shared nature of human genetic variation" 9am Wed Maike Morrisson @maikemorrison.bsky.social "A General FST Framework Reveals the Variability of Rare Versus Common Alleles "

(1/9) Our work (with @xliaoyi.bsky.social @arbelharpak.bsky.social) exploring the role of genes that escape X-chromosome inactivation in shaping the genetic architecture of sex-specific traits is now officially out in Molecular Biology and Evolution! academic.oup.com/mbe/article/...

Excited to share our new preprint from the @arbelharpak.bsky.social Lab! How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21) www.biorxiv.org/content/10.6...

Representation in genetic studies affects inference about genetic architecture

Knowledge of a trait's "genetic architecture," namely the joint distribution of allele frequencies of causal variants and the direction and magnitude of their effects, is essential to understanding it...

biorxiv.org

I’m very excited to share our new preprint with @arbelharpak.bsky.social! We meta-analyze male-female allele frequency divergences across studies (gnomAD, UKB, AoU) and ask what drives the observed differences. (1/12) www.biorxiv.org/content/10.6...

I am excited to share the first first-author paper of my PhD describing work with Changde Cheng, Mark Kirkpatrick and @arbelharpak.bsky.social has been published at AJHG! We ask if sex-differential gene expression drives sex-differential selection in humans. (1/14) www.cell.com/ajhg/fulltex...

No evidence for sex-differential transcriptomes driving genome-wide sex-differential natural selection

We assess the evidence for a genome-wide relationship between sex differences in gene expression and sex differences in natural selection. We develop an improved model for testing this association but...

cell.com