Study identifies gene that may influence opioid addiction risk | Anesthesiology | Washington University School of Medicine in St. Louis

Researchers at WashU Medicine have identified a gene that may help explain why some individuals are more likely than others to develop opioid addiction. The study builds on human genetic studies sugge...

anesthesiology.wustl.edu

How enriching the environment may combat fentanyl addiction

Rat study shows that introducing new objects in a nonsocial environment dampens fentanyl use over time and relapse-like behavior triggered by stress.

eurekalert.org

Un interruptor del dolor en el cerebro: un experimento logra acabar con el sufrimiento sin efectos secundarios

Un estudio en ratones prueba que es posible eliminar la sensación de dolor a la vez que se evita el riesgo de adicción de los opioides

elpais.com

Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects Against Stress-Induced Reinstatement in Both Male and Female Rats

Environmental enrichment (EE) reduces vulnerability to multiple drugs of abuse, yet its impact on fentanyl use and relapse-like behavior remains unclear. Here, we tested whether long-term, non-social,...

biorxiv.org

Modulation of dorsal hippocampal SK2 channels regulates morphine-enhanced neuronal oscillations and morphine-induced contextual memory encoding and retrieval - Scientific Reports

Persistent maladaptive drug-context associations are a key component of relapse vulnerability and pose a major obstacle in treating opioid use disorder. Although the dorsal hippocampus (dHPC) is criti...

link.springer.com

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Mouse study links chronic pain to disrupted sleep patterns

Researchers at Washington University in St. Louis School of Medicine have developed the first mouse model to replicate the disrupted sleep patterns seen in people with chronic pain.

source.washu.edu

Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture - Neuropsychopharmacology

Neuropsychopharmacology - Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture

nature.com

Estrogen curbs fentanyl intake by suppressing brain’s reward response

A new study in Neuron suggests that men may be biologically more vulnerable to misusing opioids like fentanyl in response to pain. The findings point to estrogen’s ability to suppress brain reward cir...

psypost.org

Female Sex Hormones Reduced Fentanyl Use in Rats

Exploring how sex differences regulate dopamine responses could inform novel interventions to prevent or treat substance use disorders.

the-scientist.com

Opioid overdose treatment bypasses brain, eases side effects

It may not be necessary to get drugs into the brain to block the lethal effects of a fentanyl overdose...

thenakedscientists.com

Female sex hormone protects against opioid misuse, rat study finds | WashU Medicine

Male – but not female – rats in chronic pain self-administer increasing amounts of fentanyl, which is prevented with estrogen treatment

medicine.washu.edu

Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males

Higginbotham et al. show that inflammatory pain increases opioid-evoked dopamine neuron activity to promote fentanyl use selectively in males. Ovarian hormones offer females protection, but estradiol’...

cell.com

Researchers identify new therapeutic strategy for fentanyl overdose

Blocking peripheral opioid receptors with naloxone methiodide sufficiently prevents and reverses fentanyl-induced cardiorespiratory depression without causing the aversive effects of naloxone in roden...

elifesciences.org

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