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Neuropsychopharmacology

@npp-journal.bsky.social

Neuropsychopharmacology (NPP) is an official peer-reviewed publication of the American College of Neuropsychopharmacology. We report discoveries and promote training & outreach initiatives.

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Neuropsychopharmacology@npp-journal.bsky.social · yesterday

New findings show that the GluN2A-selective positive allosteric modulator GNE-5729 improves specific executive functions in a state-dependent manner, advancing our understanding of targeted NMDA receptor modulation

Differential and state-dependent effects of the GluN2A-selective positive allosteric modulator GNE-5729 on executive functions

Neuropsychopharmacology - Differential and state-dependent effects of the GluN2A-selective positive allosteric modulator GNE-5729 on executive functions

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · 4d ago

This study identfied circuit-specific mechanism through which top-down cortical controls supports sustained attention, potentially informing treatments for attentional deficits

Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

Neuropsychopharmacology - Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · last wk.

This double-blind RCT combines amisulpride administration and cerebral blood flow measurement in both healthy adults and patients with MDD to highlight the ventral striatum as a potential target for anhedonia

Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study

Neuropsychopharmacology - Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · 2w ago

Congratulations to @acnporg.bsky.social Member @kundakoviclab.bsky.social on delivering an excellent #TEDx talk on Women's Health - and being honored as an Editor's pick 🤩 (I'm sure our own @npp-journal.bsky.social editors would have picked her talk also 😉)

Marija Kundakovic@kundakoviclab.bsky.social · 2w ago

I am thrilled to share my #TEDx talk, selected as an Editor's pick by the main TED Editorial team! This is a rare distinction reserved for well <1% of TEDx talks. I feel humble & shaken & so happy for this highlight on #WomensHealth & #perimenopause . Knowledge is Power! youtu.be/zX3Ya88sxcQ?...

Negar Fani@negarfani.bsky.social · 4w ago

Thank you for featuring our exciting findings, showing how a simple sternal vibration device offers a low effort way to enhance interoception, with effects on white matter plasticity! Alexa Kondas and @timmcdermottphd.bsky.social were the stars here

Neuropsychopharmacology@npp-journal.bsky.social · 2mo ago

Can vibration improve body connection and brain plasticity? Participants who received sternal vibration during brief mindfulness meditation showed enhanced body awareness and enhanced plasticity in a related brain pathway

Jeremy Hogeveen@jeremyhogeveen.bsky.social · 4w ago

We ( @vincentcostaphd.bsky.social and I ) wrote a "Hot Topics" piece for @npp-journal.bsky.social on the potential utility of frontopolar cortex TMS in precision psychiatry. Relevant now that this region has been accessed in some excellent recent NHP studies. www.nature.com/articles/s41...

Translating macaque frontopolar cortex discoveries into psychiatric treatments - Neuropsychopharmacology

Neuropsychopharmacology - Translating macaque frontopolar cortex discoveries into psychiatric treatments

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · 2w ago

This recent study identified altered LC-norepinephrine function as a potential mechanism linking early life adversity to long-lasting cognitive and affective dysfunction

Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology

Neuropsychopharmacology - Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · 2w ago

Meta-analytic evidence supports 5-HT3 receptors as a promising therapeutic target and provides rationale for repurposed 5-HT3 antagonists to address the persistent cognitive and motivational deficits of schizophrenia

Serotonin type 3 receptor (5-HT3R) antagonists for negative symptoms and cognitive impairment associated with schizophrenia: a systematic review and meta-analysis

Neuropsychopharmacology - Serotonin type 3 receptor (5-HT3R) antagonists for negative symptoms and cognitive impairment associated with schizophrenia: a systematic review and meta-analysis

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · 2w ago

This randomized crossover trial in healthy adults suggests that LSD induces sustained behavioral and neural changes that may support learning and psychological flexibility

Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study

Neuropsychopharmacology - Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · 3w ago

A modified rodent effort-related choice task (mERC) is a sensitive preclinical tool for studying effort-based decision-making and screening potential treatments for motivational dysfunction

Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators

Neuropsychopharmacology - Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · 3w ago

Our latest NPP "Meet the Author" interview features Ty Shannon and Mariam Najeeb, discussing their recent paper, "Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome in mice" 👇

npp's "Meet the Author" Interview with Ty Shannon and Mariam Najeeb

In this episode, we spoke with Ty Shannon and Mariam Najeeb (The Ohio State University) about their recent Neuropsychopharmacology publication, "Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice". You can read the full article here: https://www.natu

youtube.com

Neuropsychopharmacology@npp-journal.bsky.social · 3w ago

CBD shows promise beyond seizure control: Sleep disturbances are highly prevalent in epilepsy & neurodevelopmental disorders. In a mouse model of Angelman syndrome, CBD improved REM sleep, restores daily sleep rhythms, & reduces spontaneous seizures

Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice

Neuropsychopharmacology - Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · 4w ago

There's no better way to start September than with a rundown of the latest NPP articles 🤩 #TWiNPP Learn more about 🧠 changes after antipsychotic treatment, effects of cannabis on stress relief, DA in pain, somatosensory regulation of food intake & cannabinoid treatments for inflammatory pain 💊

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Neuropsychopharmacology@npp-journal.bsky.social · 4w ago

Using longitudinal data from the ABCD Study, white matter microstructure and impulsivity prospectively predicted non-suicidal self-injury in youth, revealing important sex differences in risk pathways

White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences

Neuropsychopharmacology - White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences

nature.com