The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition. cornell.wd1.myworkdayjobs.com/CornellCaree...

Technician III - Department of Microbiology

Position Summary This position will be in the lab of Dr. Joseph E. Peters in the Department of Microbiology. Research in the Peters’ lab broadly involves deciphering mechanisms in genome stability and...

cornell.wd1.myworkdayjobs.com

De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems www.biorxiv.org/content/10.1...

De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems

Programmable DNA integration using CRISPR-associated transposons (CASTs) offers powerful capabilities for genome engineering. The single effector Cas12k CAST examples evolved from a fixed guide TnpB n...

biorxiv.org

The RecBCD complex interacts directly with the DNA sliding clamp in Escherichia coli https://www.biorxiv.org/content/10.1101/2025.08.20.671105v1

Great to have former lab member Mike Petassi for a seminar with our Replication, Recombination, and Repair group! Presenting some of his postdoc work in the @dnacurtain.bsky.social lab. cals.cornell.edu/microbiology...

Looking forward to this new installment of the Woods Hole Mobile DNA Meeting! Fantastic program, laid-back atmosphere, and gorgeous setting at the Marine Biological Laboratory ⛵️🪼🐋 Abstract submission closes Aug 7 but registration after that date is possible. www.eventsquid.com/event.cfm?ev...

Tn7 family transposons that include all of the guide RNA-directed transposons (CAST) are common in bacteria. We now find diverse representatives across archaea, with many in the Asgard group. Reviving an Asgard element confirmed the exciting behaviors of the family #MicroSky #TESky

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · last yr.

Tn7 family bacterial transposons known for tightly controlled target site selection are distributed across Asgard and archaeal groups https://www.biorxiv.org/content/10.1101/2025.07.27.667033v1

Very excited about our work from @jordanthesier.bsky.social and @popomicro.bsky.social et al. We find that Tn7 family elements common in bacteria (that include all of the guide RNA-directed transposons, CAST) are also found across archaea including many in the exciting Asgard group! #MicroSky #TESky

Jordan 🧬@jordanthesier.bsky.social · last yr.

My first co–first author paper with the amazing PoPo @popomicro.bsky.social is now on bioRxiv ! 🧬 We found that Tn7-like transposons - known for finding specific insertion sites before they jump - aren’t just in bacteria. They're in archaea distributed across all major superphyla!

Today is the last day to submit to be considered for a podium presentation at the EMBO transposon meeting this Fall. The organizers prioritized speaker slots sourced from submitted abstracts, we want to hear about your science!

Julius Brennecke@juliusbrennecke.bsky.social · last yr.

last call! submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field. #MicroSky #Metals rdcu.be/eycU2

Microbial metal physiology: ions to ecosystems

Nature Reviews Microbiology - Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review,...

rdcu.be

We're hiring! Do you have experience engineering yeast and using CRISPR? Jose Avalos and I are hiring a joint postdoc to work on an exciting fast-paced DARPA project with a great team at Neochromosome, Fermeate, and @joepeterslab.bsky.social puwebp.princeton.edu/AcadHire/app...

Happy Transposon Day! 🧬➰🧬 Commemorating Barbara McClintock's birthday (June 16th, 1902-1992). #TransposonDay2025

Linking to #microsky #transposon

Joe Peters Lab@joepeterslab.bsky.social · last yr.

Exciting work from the Guarné lab indicating how the elusive TnsE pathway of prototypic Tn7 recognizes DNA replication features using an asymmetric dimer to integrate multiple signals at DNA replication forks linking target recognition to transposase recruitment doi.org/10.1093/nar/...

Exciting work from the Guarné lab indicating how the elusive TnsE pathway of prototypic Tn7 recognizes DNA replication features using an asymmetric dimer to integrate multiple signals at DNA replication forks linking target recognition to transposase recruitment doi.org/10.1093/nar/...

First podcast recording of the day. Guest is Dr. Tory Hendry of Cornell University, chatting about interactions between fluorescent Pseudomonas and aphids!

𝘢𝘧𝘪𝘤𝘪𝘰𝘯𝘢𝘥𝘢𝘴 & 𝘢𝘧𝘪𝘯𝘰𝘯𝘢𝘥𝘰𝘴 of chromosome ends (bacterial!) take note 👇 #MicroSky

Joe Peters Lab@joepeterslab.bsky.social · last yr.

A thread from the Postdoc who led the work on bacterial Telomeric transposons. A wonderful collaboration with the Barabas lab. Officially out in the journal today!

wow, telomeric transposons in bacteria with linear chromosomes! (of course this was first figured out in flies, inc by Bob Levis, who i was happy to see few days ago at the fly meeting). 🪰 www.science.org/doi/10.1126/... www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...

Telomeric transposons are pervasive in linear bacterial genomes

Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric tran...

science.org

A thread from the Postdoc who led the work on bacterial Telomeric transposons. A wonderful collaboration with the Barabas lab. Officially out in the journal today!

@popomicro.bsky.social · last yr.

In eukaryotes, some transposons target telomeres; in Drosophila, they even replace them. Peters lab and Barabas group show that bacteria with linear genomes also harbor diverse telomeric transposons. doi.org/10.1126/scie... @joepeterslab.bsky.social

Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch

Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/...

Telomeric transposons are pervasive in linear bacterial genomes

Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...

science.org

Our preprint is now published www.science.org/doi/10.1126/...

Telomeric transposons are pervasive in linear bacterial genomes

Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...

science.org

Joe Peters Lab@joepeterslab.bsky.social · 2y ago

Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear chromosomes and plasmids. We identified several families of independently evolved telomeric transposons in cyanobacteria and Streptomyces. 1/7 www.biorxiv.org/content/10.1...

Very excited about this work from graduate student Laura Chacon Machado now published in Mobile DNA, "A family of Tn7-like transposons evolved to target CRISPR repeats"! #TESky

Laura Chacon Machado@laurachaconmachado.bsky.social · last yr.

Our preprint describing a family of Tn7-like transposons that evolved to target CRISPR repeats is now published at Mobile DNA #Tn7 #transposons #mobileDNA 1/10 mobilednajournal.biomedcentral.com/articles/10....

AIR-BORNE EXCERPT! Louis Pasteur climbed a glacier to hunt for floating germs. There he discovered a fundamental truth about all life. Here's the story, from my new book. [Gift link] Artwork by Antoine Maillard. 🧪 1/2 www.nytimes.com/2025/02/17/s...

I had the great pleasure of interacting with Bik Tye and her lab for many years at Cornell where she was one of the founding members of our DNA Replication, Recombination, and Repair (R3) group. It was wonderful to see this profile in PNAS www.pnas.org/doi/10.1073/...

Want to learn more about genetic tools for studying bacteria and phage, check out the summer ABG Course at CSHL. This will be the 80th anniversary of the original CSHL Phage course, so you'll also meet many additional visiting genetics gurus! <https://meetings.cshl.edu/courses.aspx?course=C-ABG>

If there's something we don't understand I assume transposons are responsible unless proven otherwise

Feeney also donated nearly 1 billion to Cornell Univ., which now has a street on campus named in his honor! news.cornell.edu/stories/2023...

Chuck Feeney, Cornell’s ‘third founder,’ dies at 92 | Cornell Chronicle

Charles F. “Chuck” Feeney ’56, founding chairman of The Atlantic Philanthropies and Cornell University’s most generous donor, died Oct. 9 in San Francisco. He was 92.

news.cornell.edu

Wim Meijer@wimgmeijer.bsky.social · 2y ago

There are billionaires and then there is Chuck Feeney He founded the Atlantic Philanthropies, one of the largest private charitable foundations in the world Feeney anonymously gave away his fortune of over $8 billion One billion went to Irish third level education, including my university, UCD 🧪🦠

We strongly endorse the naming of 𝘚𝘵𝘳𝘦𝘱𝘵𝘰𝘮𝘺𝘤𝘦𝘴 𝘨𝘰𝘵𝘵𝘦𝘴𝘮𝘢𝘯𝘪𝘢𝘦 (DSM 3412) in honor of Susan Gottesman #MicroSky #microbiology

Leibniz Institute DSMZ@leibniz-dsmz.bsky.social · 2y ago

Honouring Susan Gottesman’s major contributions in the field of microbiology, biochemistry & molecular biology, DSMZ researchers named the strain Streptomyces gottesmaniae (DSM 3412) after her. #herstory #HonoringWomenInSTEM #WomenInScience #antibiotics #mRNA #streptomycete #microbiology

Honouring Esther Lederberg’s outstanding work on bacterial gene regulation, recombination and exchange, DSMZ researchers named the strain Streptomyces lederbergiae (DSM 44399) after her. #herstory #WomenInScience #microbiology #genetics

#MicroSky undergraduates! Please check out our summer REU opportunity!

Tory Hendry@thendry.bsky.social · 2y ago

We’re excited to advertise the Microbial Friends and Foes REU program! Please share info with your undergrads, for 10 weeks paid research experience at Cornell. Apps due on Feb 1. @heatherfeaga.bsky.social cihmid.cornell.edu/academics-pr...

Review on guide RNA-directed transposition (CAST) with an eye to functional genomics, "The promise of CRISPR-associated transposons for bacterial functional genomics" (Note JM Peters is not me or a relative, but is a friend and former coauthor!). #TEsky #MicroSky doi.org/10.1016/j.mi...