The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox: www.nature.com/articles/s41...

One of the last works from my PhD is finally out! We delved deep into water dynamics as a function of pH, in a series of high-resolution structures. The manuscript is now online at @pnas.org! If you're into high-res biochemical insights, I promise its worth the read! #cryoEM #biochemistry #SPA

Direct evidence of acid-driven protein desolvation | PNAS

Water and its ability to modulate the protonation states of biomolecules govern the physical chemistry of life, dictating their metabolic functions...

pnas.org

Does anybody have a working protocol for a pipeline including aretomo3 to pytom-tm to warptools for #STA? I would ideally like to use M for the final refinements instead of being confined to relion5. Any suggestions/resources would be welcome! #teamtomo #cryoet #cryoem

Direct evidence of acid-driven protein desolvation www.biorxiv.org/content/10.1101/2025.09.01.673474v1 #cryoEM

A project that would never leave my mind during my PhD is finally out! We used #cryo-em #spa #md to see how the solvation layer of a protein is affected during acidification! Really cool insights and a truly fundamental work, congrats to all involved! www.biorxiv.org/content/10.1...

Direct evidence of acid-driven protein desolvation

Water and its ability to modulate the protonation states of biomolecules govern the physical chemistry of life, dictating their metabolic functions. However, how amino acid protonation alters protein ...

biorxiv.org

The first project I worked on, right after joining @bijvoet-centre.bsky.social!

cryoEM papers@cryoempapers.bsky.social · last yr.

Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus www.biorxiv.org/content/10.1101/2025.03.19.643997v1 #cryoEM

Damn, I'm sad I just found out about this one only now!

Frank Noe@franknoe.bsky.social · 2y ago

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...

I guess I should have posted a bit earlier, but I'm very excited that my #MSCA application got accepted! I'll be working at @fridof.bsky.social lab @utrechtuniversity.bsky.social to develop my #teamtomo skills on my project: Protein ER-ways! Here's to gaining new insights on ER protein biogenesis!

Having now worked myself on tomo data collection and analysis makes me appreciate the enormity of this work even more! Amazing stuff...

Beck Laboratory@becklab.bsky.social · 2y ago

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below: