Can RNA itself drive toxicity in Huntington’s disease? Join the Kaiser lab (Bijvoet Centre, Utrecht University) to tackle this question using cutting-edge single-molecule biophysics, optical tweezers & fluorescence microscopy. www.uu.nl/en/organisat...

PhD Position on Biophysical Origins of RNA Toxicity in Huntington’s Disease

Exciting Opportunity for a PhD Researcher: Join our team to investigate molecular mechanisms in Huntington’s Disease!

uu.nl

Very happy and honored to be elected as an EMBO member. Looking forward to contributing to this great European society. Thanks for being nominated and the trust of the members.

EMBO@embo.org · 3mo ago

Welcome and congratulations to the 60 new members and 11 associate members who have been elected to the EMBO Membership! They join a community of more than 2,200 leading scientists. 🧪 https://www.embo.org/press-releases/seventy-one-leading-scientists-elected-to-the-embo-membership/ #EMBOMembers2026

The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox: www.nature.com/articles/s41...

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

33 million euro investment for national electron microscope facility EMPower

A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...

uu.nl

Congratulations Marten! We hope this new version of pytom will be useful to many cryo-ET enthusiasts.

Marten Chaillet@martenchaillet.bsky.social · last yr.

Final PhD paper now reviewed and published in JSB:X. I was happy with some great reviews that improved the paper! Thanks to Sander Roet for his help with the code base, and Remco Veltkamp and @fridof.bsky.social

Exciting Bijvoet Seminar by Marie-Eve Aubin-Tam from @tudelft.bsky.social on the engineering of bioinspired and living materials!

Online today at @naturecomms.bsky.social and a great opportunity for our first post @bsky.app: in a major team effort, we reveal the structural mechanisms for centrosomal recruitment and organization of the human microtubule nucleator γ-TuRC: www.nature.com/articles/s41...

Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC - Nature Communications

The γ-TuRC plays a central role for nucleation of microtubules at the centrosome. Here, the authors dissect structural mechanisms for centrosomal recruitment and regulation of the γ-TuRC and identify ...

nature.com

And now to something completely different: the response of an anaerobic archaeon to oxidative stress. Tubular nanocompartments encapsulate virus-like particles! Great work by Wenfei Song and many colleagues from @bijvoet-centre.bsky.social and @mib-wur.bsky.social. www.biorxiv.org/content/10.1...

Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus

Reactive oxygen species (ROS) pose a significant threat to biological molecules, prompting organisms to develop systems that buffer oxidative stress and contain iron, which otherwise amplifies ROS pro...

biorxiv.org

Center for Molecular Medicine at UMC Utrecht is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but also candidates with a more advanced career are very welcome to apply. www.werkenbijumcutrecht.nl/vacatures/we...

Center for Molecular Medicine

cmmutrecht.eu

I guess I should have posted a bit earlier, but I'm very excited that my #MSCA application got accepted! I'll be working at @fridof.bsky.social lab @utrechtuniversity.bsky.social to develop my #teamtomo skills on my project: Protein ER-ways! Here's to gaining new insights on ER protein biogenesis!

In one of our first publications in 2025, with colleagues from St. Louis, Leiden and Boston, we shed light on the molecular mechanisms of motile cilia, structures used by cells to propel themselves through fluid or to move fluid across their surfaces. www.nature.com/articles/s41...

Structural diversity of axonemes across mammalian motile cilia - Nature

Cryoelectron microscopy, cryoelectron tomography and proteomics are used to resolve the 96-nm modular repeat of axonemal doublet microtubules from both sperm flagella and epithelial cilia of the ovidu...

nature.com

Starkes Signal!! Über 60 dt. Hochschulen & Forschungsinstitutionen haben heute ihren Ausstieg bei X bekanntgegeben, s.u. #eXit X sei nicht mehr vereinbar mit ihren Grundwerten: „Weltoffenheit, wissenschaftliche Integrität, Transparenz und demokratischer Diskurs.“ Liste der Beteiligten hier:

Hochschulen und Forschungsinstitutionen verlassen Plattform X - Gemeinsam für Vielfalt, Freiheit und Wissenschaft

nachrichten.idw-online.de

My new life in blue starts with sharing a preprint of amazing Max Gemmer’s ex vivo analysis that sheds light on the machinery responsible for inserting many multispanning transmembrane proteins into the ER membrane #teamtomo: www.biorxiv.org/content/10.1...

Exploring the molecular composition of the multipass translocon in its native membrane environment

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org