Yet another phenomenal paper! @audreycluo.bsky.social is an absolutely star!

Audrey Luo@audreycluo.bsky.social · 7mo ago

We think of white matter as the highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My final PhD paper, “Two Axes of White Matter Development”, is now out in @natcomms.nature.com! 🛣️🧠✨ 🔗 bit.ly/wm2axes

Ever wondered how white matter tracts actually map onto the cortical hierarchy and cognition—beyond the usual “projection vs association” labels? Our new preprint tackles exactly that! 🧠✨ doi.org/10.64898/202... Thread below 🧵

Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity

Long-range white matter (WM) tracts support cognition by enabling communication between distant cortical regions, which are organized along a hierarchy defined by the sensorimotor-to-association (S-A)...

doi.org

Psychedelics disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/psychedelics...

Psychedelics muddy fMRI results: Q&A with Adam Bauer and Jonah Padawer-Curry

The drugs disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help…

thetransmitter.org

🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550 www.biorxiv.org/content/10.1...

Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of mouse and human brain function @adamqbauer.bsky.social @jordacular.bsky.social @realjoshsiegel.bsky.social @oliverk28.bsky.social www.nature.com/articles/s41...

Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function - Nature Neuroscience

Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI studies of psychedelics.

nature.com

A study in Nature Neuroscience finds psychedelics disrupt the relationship between neuronal activity and blood flow in humans and mice. This suggests fMRI results under psychedelics may reflect vascular effects as much as neural ones and should be interpreted with caution. go.nature.com/47hqVPH 🧪

And the story continues to grow!!!

Rick Zirkel@rick-zirkel.bsky.social · last yr.

Excited to share our latest work is up on bioRxiv! Looking at capillary flow speed changes we show that psilocybin prolongs the neurovascular coupling response to a visual stimulus. 🍄🔬🧠🩸 @chris-schaffer.bsky.social @alexkwan.bsky.social @sn-lab.bsky.social Preprint: www.biorxiv.org/content/10.1...

New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬 We found that psilocybin prolongs the neurovascular response, independent of neural activity. This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️

Rick Zirkel@rick-zirkel.bsky.social · last yr.

Excited to share our latest work is up on bioRxiv! Looking at capillary flow speed changes we show that psilocybin prolongs the neurovascular coupling response to a visual stimulus. 🍄🔬🧠🩸 @chris-schaffer.bsky.social @alexkwan.bsky.social @sn-lab.bsky.social Preprint: www.biorxiv.org/content/10.1...

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging

Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function

Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...

nature.com