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@realjoshsiegel.bsky.social

23 Posts94 Follower34 Folgt
@pineurosci.bsky.social · 4mo ago

New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! www.pnas.org/doi/10.1073/... Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

@realjoshsiegel.bsky.social · 4mo ago

Excited to see this out in PNAS. A fabulous project by Adam Pines and the Williams lab: across psychedelics (LSD, Psilo, MDMA), species, and datasets, a very consistent story—reduced propagation of activity into the default mode network (DMN). Congrats Adam! 🧠🍄 www.pnas.org/doi/10.1073/...

Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice | PNAS

Psychedelic drugs are poised to become mainstream treatments, yet we lack a circuit-level account of how they reshape brain activity. Emerging evid...

pnas.org

@realjoshsiegel.bsky.social · 8mo ago

The big questions facing psychedelic science: 1. What’s the biology of psychedelic experiences? 2. Is the experience necessary for clinical benefit? 3. How do we solve expectancy+unblinding in trials? We synthesize what we know and the big Qs in a Nature Med Review: nature.com/articles/s41...

The science of psychedelic medicine - Nature Medicine

This Review outlines the science behind psychedelic medicine and integrates mechanistic knowledge with clinical evidence across neuropsychiatric indications, highlighting challenges, controversies and...

nature.com

WashU Medicine@washumedicine.bsky.social · 8mo ago

Parkinson's disease affects over 10 million people worldwide. A new study led by WashU Medicine researchers is paving the way for more personalized, non-invasive treatment, tackling this neurological disorder at its root. @ndosenbach.bsky.social medicine.washu.edu/news/brain-n...

Brain network responsible for Parkinson’s disease identified | WashU Medicine

In a new study, treatments targeted to the network resulted in greater improvements in symptoms compared to treating nearby brain regions.

medicine.washu.edu

@realjoshsiegel.bsky.social · last yr.

This extraordinary psychedelic dataset is now fully/freely available to all! All the info to access & use it in a newly published Nature Scientific Data Resource: rdcu.be/epxe7 Thanks to the incredible team who created it - Subha S, Rick R, Ginger N, to name a few. Translate that into Japanese!

Psilocybin’s acute and persistent brain effects: a precision imaging drug trial

Scientific Data - Psilocybin’s acute and persistent brain effects: a precision imaging drug trial

rdcu.be

Hacker News JP@hacker-news-jp.bsky.social · 2y ago

Psilocybin desynchronizes the human brain シロシビンは人間の脳を脱同期させる 🔺 228 💬 19 🔗 HN Post | Article

@realjoshsiegel.bsky.social · last yr.

"Effects of Psilocybin on Clergy..." The resutls are just ... incredible. "participants rated their psilocybin experiences to be among the top five most spiritually significant (96%) of their lives..." liebertpub.com/doi/10.1089/...

Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions | Psychedelic Medicine

Background: Although historical writings, anthropological accounts, and experimental studies document associations between psilocybin use and religion, no prospective experimental study has investigated how the effects of psilocybin are experienced and interpreted by religious clergy. This exploratory study evaluated the overall safety and the acute and enduring effects of psilocybin in clergy. Methods: Participants were psychedelic-naïve clergy from various major world religions. A randomized, parallel group, waitlist control design was used to assess the effects of two supported psilocybin sessions, with participants receiving 20 and then 20 or 30 mg/70 kg about 1 month later. Outcomes were compared between the Immediate Group (n = 13) and the Delayed Group (n = 16) at 6 months after screening using self-report measures. The effects of psilocybin were also assessed on session days and 4 and 16 months after the second psilocybin session in the 24 participants who completed both sessions. Results: The primary outcome assessment at 6 months after screening showed that, compared with the delayed control group, participants who had received psilocybin reported significantly greater positive changes in their religious practices, attitudes about their religion, and effectiveness as a religious leader, as well as in their non-religious attitudes, moods, and behavior. Follow-up assessments showed that positive changes in religious and non-religious attitudes and behavior were sustained through 16 months after the second psilocybin session. At that time, participants rated at least one of their psilocybin experiences to be among the top five most spiritually significant (96%), profoundly sacred (92%), psychologically insightful (83%), and psychologically meaningful (79%) of their lives. Furthermore, 42% rated one of their experiences to be the single most profound of their lifetime. At 16-months follow-up, most (79%) strongly endorsed that the experiences had positive effects on their religious practices (e.g., prayer or meditation) and their daily sense of the sacred, and most (71%) reported positive changes in their appreciation of religious traditions other than their own. Although no serious adverse events were reported, 46% rated a psilocybin experience as among the top five most psychologically challenging of their lives. Conclusions: In this population of clergy, psilocybin administration was safe and increased multiple domains of overall psychological well-being including positive changes in religious attitudes and behavior as well as their vocation as a religious leader. The study was limited by a waitlist control design, homogenous sample, and the use of some unvalidated outcome measures. Further research with more rigorous control conditions and diverse samples is needed.

liebertpub.com

@realjoshsiegel.bsky.social · last yr.

The brain signature of a single dose of Ritalin in six participants in our precision functional mapping study was highly significant and well matched to stimulant effects determined in thousands of subjects in the ABCD data set. PFM provides powerful drug bio markers! Stay tuned for more on this

Benjamin Kay@benjaminkay.bsky.social · last yr.

We were so surprised, we replicated our findings in a precision imaging drug trial of healthy adults taking an experimentally controlled dose of Ritalin (methylphenidate). The stimulant trial brain maps were highly correlated with those from ABCD p < 0.001.

Benjamin Kay@benjaminkay.bsky.social · last yr.

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

Bild
Cedric Boeckx@cedricboeckx.bsky.social · last yr.

Happy to read @sydneywyatt.bsky.social’s piece on the recent study by @samkrimmelneuro.bsky.social @ndosenbach.bsky.social @gordonneuro.bsky.social re: the human red nucleus I was glad to discuss this great work with Sydney @thetransmitter.bsky.social www.thetransmitter.org/brain-imagin...

‘Old’ brainstem structure evolved beyond basic motor control

The human red nucleus may also help coordinate action, reward and motivated behavior, a new study suggests.

thetransmitter.org

Sam Krimmel@samkrimmelneuro.bsky.social · last yr.

The advancements in brainstem imaging will make it possible to examine a host of clinically relevent structures like the eriaqueductal gray and substantia nigra in humans, something that has been very hard to do well previously

@realjoshsiegel.bsky.social · last yr.

This is *crucial* to the future translational potential of resting fMRI

a man in a suit and tie is clapping his hands in a room .

ALT: a man in a suit and tie is clapping his hands in a room .

media.tenor.com

Sam Krimmel@samkrimmelneuro.bsky.social · last yr.

Additionally, networks, a well-recognized dominant model of cortical organization, also appear to be an organizing principle as far down as the brainstem. This nicely highlights that networks aren’t really ‘cortical’ they are a system of whole brain organization.

Alex Kwan@alexkwan.bsky.social · 2y ago

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12

Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature

A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

nature.com

@realjoshsiegel.bsky.social · 2y ago

Just heard a fascinating talk by Mir Jalil Razavi! 🤯 Cortical folding is driven by surface expansion. Tiny differences in cortical thickness and starting morphology drive patterning of the brain surface. Crucial info to anyone who wants to localize brain function! nature.com/articles/sre...

Cortical Folding Pattern and its Consistency Induced by Biological Growth - Scientific Reports

Scientific Reports - Cortical Folding Pattern and its Consistency Induced by Biological Growth

nature.com