🚀 We’re growing! Are you passionate about human pluripotent stem cells? We are looking for 1 PhD student + 1 Lab technician to join us ☀️ ior.usi.ch/institute/jobs

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

PIEZO channels link mechanical forces to uterine contractions in parturition

Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...

biorxiv.org

BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.

@mheming.bsky.social · last yr.

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies. Explore: pns-atlas.mzhlab.com A tweetorial 1/13 doi.org/10.1038/s414...

New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...

Expansion microscopy reveals nano-scale insights into the human neuromuscular junction

Ramadan et al. employ expansion microscopy to visualize neuromuscular junctions in human and mouse muscles. Their findings demonstrate expansion microscopy as an accessible and cost-effective approach...

cell.com

🚨 Exciting opportunity to join us! 👇

Institute of Oncology Research (IOR)@iorbellinzona.bsky.social · last yr.

#IORjobs Open PhD Position! Join Arianna Baggiolini @ariannabaggiolini.bsky.social ’s Lab to work on human pluripotent stem cell (hPSC)-based models of the peripheral nervous system and disease. Info and application: ior.usi.ch/events-news/...

🚨 Exciting opportunity to join our lab 👇

Arianna Baggiolini@ariannabaggiolini.bsky.social · last yr.

📣 Join us! Were looking for a PhD student to join our lab and work on human pluripotent stem cell (hPSC)-based models of the peripheral nervous system and disease. Come be part of our supportive and dynamic lab family in the beautiful Bellinzona, Southern Switzerland 🇨🇭☀️⛰️ ior.usi.ch/events-news/...

Congrats to our brilliant postdoc🥳, @jonasvanlent.bsky.social, on receiving the Young Investigator Award from the Children’s Tumor Foundation! This recognition is a statement to the impact of your important research🌟!. We’re excited to follow your journey and see how you’ll advance science💪🌟

Institute of Oncology Research (IOR)@iorbellinzona.bsky.social · last yr.

#IORnews Jonas Van Lent receives the Children's Tumor Foundation's Young Investigator Award. Congrats @jonasvanlent.bsky.social ! Read more: shorturl.at/ObLS5

#IORnews Jonas Van Lent receives the Children's Tumor Foundation's Young Investigator Award. Congrats @jonasvanlent.bsky.social ! Read more: shorturl.at/ObLS5

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...

Retromer promotes the lysosomal turnover of mtDNA

Lysosomal uptake of mtDNA controls mitochondrial quality.

science.org

Check out this brief overview of human stem cell models and their promise in the @thetransmitter.org.web.brid.gy #hipscells #stemcells #organoids #assembloids #braindisorders

The Transmitter @thetransmitter.bsky.social · 2y ago

Sophisticated 3D cultures reveal previously inaccessible stages of human brain development and enable the systematic study of disease genes, writes @sergiuppasca.bsky.social in the latest essay in our series “Frontiers in human neurotechnology. www.thetransmitter.org/human-neurot...

In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n

Macrophages protect against sensory axon loss in peripheral neuropathy @Nature www.nature.com/articles/s41...

Macrophages protect against sensory axon loss in peripheral neuropathy - Nature

A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.

nature.com

In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.biorxiv.org/content/10.1... Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al. @uclqsion.bsky.social #aging

So exciting to see our newest paper on muscle-nerve crosstalk featured in this @cellpress.bsky.social Device perspective - thanks to Claudia Loebel and team for highlighting our work! 💪🏽 www.cell.com/device/abstr...

An in vitro model for studying crosstalk between muscle cells and neurons

Muscle contraction and exercise are critical for peripheral nerve growth and innervation. Studying this interplay is challenging given the difficulty of decoupling mechanical from biochemical stimulat...

cell.com

👏 to Tetsuo Hasegawa & others of Clatworthy lab & beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch www.nature.com/articles/s41...

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology

Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...

nature.com