David Pla Martin
@dplamartin.bsky.social
Professor @hhu_de Mitochondrial Biology 🧬 | Institute of Biochemistry and Molecular Biology I | mitochondria, mtDNA and mitophagy http://bit.ly/bumb1
"The real work is not convincing myself I belong …. Instead, the challenge is rewiring my own perspectives and my responses to the subtle and persistent messages telling me I’m not what a professor looks like." #ScienceWorkingLife https://scim.ag/4xdo4TI
To all #mitochondria lovers: Euromit 2026 early-bird registration is coming up!
Euromit-2026@euromit-2026.bsky.social · 6mo ago📢 New update on our website! 👉Don't forget : early‑bird rates are available until Februray, 17 !! 👉 : www.euromit2026.eu/article/book... #EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social
Hey, science community (whoever is here). Can you please help me amplify this message? Postdoc position available in Düsseldorf!
Are you interested in a postdoctoral position? Do you have experience in mitochondrial biology and in vivo research? Please send me your CV!
New Year, new EU goals 🌍 Here are some of our top priorities for 2026 ⬇️
🎄 Wir wünschen allen, die feiern, frohe und besinnliche Weihnachtstage und schöne Momente im Kreise eurer Liebsten!
MISO: An MTFP1 interactor that regulates inner mitochondrial membrane fusion and quality control MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains | Nature Cell Biology
MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains - Nature Cell Biology
Zhang et al. characterize the mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner mitochondrial membrane stress by inducing membrane subdomains promoting homeostat...
share.google
We are hiring!. If you hold a PhD in natural science and are passionate about mitochondria, reach out!
Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/
Im neuen BIOspektrum: Spannendes zur Qualitätskontrolle der Mitochondrien: www.biospektrum.de/system/files... @dplamartin.bsky.social
🦆 Junge Stud-Ente genießt das Nachtleben auf dem Campus. Danke @mel_nrv für das Foto! 🥰 ^lm
🌟 Exciting news! Dr. David Pla Martin is joining our Cell & Molecular Biology section as an editorial board member. @dplamartin.bsky.social's work in mitochondrial function, mtDNA, mitochondrial quality, and selective mitophagy will be a fantastic addition. Welcome! 🧬🔋🧫
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org. rdcu.be/eKKz1 🇨🇦
Protein complex, the retromer, promotes recycling/disposal of damaged mitochondrial DNA 📷 Parisa Kakanj & Mari Bonse et al @dplamartin.bsky.social lab University of Cologne, Cologne, Germany in @science.org Science Advances ➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social
Small molecules restore mutant mitochondrial DNA polymerase activity www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
nature.com
What a lovely paper from @dplamartin.bsky.social and his team! Mechanistic insight to mtDNA turnover at the lysosomes. 📬
David Pla Martin@dplamartin.bsky.social · last yr.Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
science.org
Are u tired of reading about tariffs? Then take a look to our last work! @science.org www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
science.org
Tomorrow will be a good day! I can’t wait to show you what we have…
A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A www.life-science-alliance.org/content/8/6/...
The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation
Pathogenic variants in the mitochondrial protein MFN2 are typically associated with a peripheral neuropathy phenotype, but can also cause a variety of additional pathologies including myopathy. Here, ...
life-science-alliance.org
Being a PI is hard, we have to deal with one rejection after another, hours of work amounting to nothing because someone thinks our ideas aren’t cool enough. But then, suddenly, you get a yes! And life shines again. Thanks, @dfg.de , for your support!
I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
Whoa - are a significant proportion of sporadic ALS/motor neuron disease cases a mitochondrial DNA disease?! #mitochondria www.nature.com/articles/s41...
Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis - Nature Neuroscience
Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV induce...
nature.com
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Combined expression of a mitochondrially targeted endonuclease and end-joining machinery enables formation of mtDNA deletions with a broad range of heteroplasmy.
cell.com
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Combined expression of a mitochondrially targeted endonuclease and end-joining machinery enables formation of mtDNA deletions with a broad range of heteroplasmy.
cell.com
