Very excited for my next full length Substack post, which will be a deep dive into thymic regeneration, complete with history, risks & benefits, and pharma protocols. In the meantime, here’s a teaser on the topic, shared earlier this year 🧪: #Longevity #Aging

Jon Brudvig@jonbrudvig.bsky.social · 2y ago

Did you know that your thymus hasn’t been fully functional since you were an infant? Since that time, it has progressively “involuted”—shrunk and been mostly replaced by fat. Without it, you can’t mature new naïve T-cells. Most of the naïve T-cells you have today were actually produced decades ago.

Recently, I sat down with Paul Taylor to discuss the intimate links between lysosomal health and aging. We touched on so many important topics in this one, with an overarching focus on practical, science-backed strategies for living a healthier life. 🧪 #Longevity

Unpacking Longevity and Cellular Health: A Conversation with Dr. Jon Brudvig - Part One

Podcast Episode · The Paul Taylor Podcast | Expert in Hardiness and Mental Fitness · 05/09/2025 · 41m

podcasts.apple.com

Last week, I sat down with David Blackmore to walk through my personal #longevity strategy. He did an excellent job distilling our conversation into key takeaways, focusing on diet, exercise, and drugs/supplement approaches. 🧪

David Roberts and Mara Labs just posted a nice, concise article on the #microplastics health problem and #sulforaphane as a potential tool for liberating the particles from cells. 🧪 Definitely worth a read if you are looking for a quick intro. mara-labs.com/blogs/journa... #Longevity

Microplastics: A Growing Threat + A Promising Solution

Most people have heard that plastic pollution is choking the oceans. Fewer realize that plastic has also invaded our bodies, even reaching our brains and blood. Startling new research reveals that the...

mara-labs.com

Lithium prevents Alzheimer’s. Here’s how to use it. 🧪 jonbrudvig.substack.com/p/lithium-pr... #Alzheimer's #Longevity #Prevention

Lithium Prevents Alzheimer’s—Here’s How to Use It

Even as evidence builds, most experts hesitate to recommend lithium for Alzheimer’s prevention. That’s a mistake.

jonbrudvig.substack.com

Even as evidence builds, many experts hesitate to recommend lithium for Alzheimer’s prevention. That’s a mistake. 🧪 My latest post breaks down the science and gives practical recommendations for implementation. jonbrudvig.substack.com/p/lithium-pr... #Alzheimer's #Longevity #BrainHealth

Lithium Prevents Alzheimer’s—Here’s How to Use It

Even as evidence builds, most experts hesitate to recommend lithium for Alzheimer’s prevention. That’s a mistake.

jonbrudvig.substack.com

What’s the rationale for and against metformin for #longevity? First, how does it work? As we’ve discussed in recent posts, metformin acts in the gut by binding a lysosomal protein called PEN2 and activating a response that increases production of incretin hormones like GLP-1, GIP, and PYY. 🧪

This week in the Lancet: “Plastics cause disease and death from infancy to old age and are responsible for health-related economic losses exceeding $1.5 trillion annually.” 🧪 A quick break down and call to action in this thread. #Microplastics #Longevity

It was fun to see Felix Harder break down my #microplastics experiments on YouTube 🧪: www.youtube.com/watch?v=JZaJ... I'm working on a follow up post now, with a science update and protocol insights. Stay tuned! Original post on Substack: jonbrudvig.substack.com/p/first-evid...

We Finally Know How To Detox Microplastics From Our Cells

YouTube video by Felix Harder

youtube.com

Metformin doesn’t just lower glucose; it teaches your gut how to sense nutrients again. Two new papers show exactly how this works, and why it matters. 💊🧪💊 Broken down in this thread. #Longevity #Aging #Healthspan

Life is Shorter Than You Think. Don’t Miss Your Bonus Chapter. My new full-length post is a simple inquiry into the true impact of lifestyle interventions, with simple, striking visuals that reframe the entire question. jonbrudvig.substack.com/p/life-is-sh... #Longevity #Healthspan #Aging 🧪

Psilocybin extends lifespan in mice. But this is bigger than just a new geroprotective drug; it suggests an entirely new drug target—and it probably isn't the one you think. 🧪🧠🧪 substack.com/profile/1091... #longevity #psychedelics #psilocybin

In case you missed it, my last Substack post summarizes the #microplastics problem for human health and shares some encouraging initial experiments into a clearance protocol. This one has generated a LOT of great discussion. Next steps are in the works! 🧪 jonbrudvig.substack.com/p/first-evid...

First Evidence of Microplastic Mobilization in a Human Subject – A Self-Experiment

I mobilized millions of microplastics in my blood using a simple supplement protocol. Could this be the key to clearing them from our bodies?

jonbrudvig.substack.com

What if a quick blood test could tell you how fast each of your organs are aging? 🧪🩸🧪 That’s the promise of Vero Bioscience, a new startup commercializing the organ-specific aging test developed by the Wyss-Coray group at Stanford. Broken down in this thread. #Longevity #Aging

This changes the scale of the #microplastics crisis. We’ve known about the 3 million tonnes (MT) of floating plastic in our oceans for years. But that’s just the surface. In the North Atlantic alone, 27 MT (9x!) of nanoplastics are suspended in the water column. 🧪 www.nature.com/articles/d41...

#Inflammaging isn’t a biological inevitability. It’s a byproduct of industrialized lifestyles, as confirmed in a new study this week in Nature Aging. Broken down in this thread. 🧪

#Microplastics are building up in your body. You can reduce your exposure, starting with three major sources you probably haven’t even thought about. 🧪🔬🪥

Turning #microplastics into Tylenol? 🧪 This isn't going to solve the plastic mess we've created, but it does illustrate how bacteria can be engineered to break down plastic, sometimes with useful bioproducts. Microbes may be the solution to the environmental problem. www.nature.com/articles/d41...

Everyday painkiller made from plastic — by E. coli

Study highlights potential for sustainable synthesis of paracetamol.

nature.com

I've noticed a lot of recent pushback on the notion of #longevity medicine 🧪 in the popular press. Respected clinicians, scientists, and thought leaders (including one of my favorites, Eric Topol) repeat the claim that “there is no evidence for these treatments.” This is objectively false.

Myostatin inhibitors have received a lot of attention in the muscle space. They work great in mice, but there's another strategy with far greater potential in humans. I break down the #Science in this thread. 🧪💊🧪 #myostatin #muscle #healthspan #longevity

Do #psychedelics and SSRIs actually relieve #depression through serotonin, or is it something else entirely? Recent evidence points to a surprising answer, broken down in this thread. 💊🧪💊

After sharing this initial report, there's been a lot of great discussion around implications and next steps. 💊🧪💊 Check it out on Linkedin: www.linkedin.com/posts/jon-br... And the full post on Substack: substack.com/home/post/p-... #microplastics #longevity #healthspan

First Evidence of Microplastic Mobilization in a Human Subject – A Self-Experiment

I mobilized millions of microplastics in my blood using a simple supplement protocol. Could this be the key to clearing them from our bodies?

substack.com

The secretome of senescent monocytes predicts age-related clinical outcomes in humans www.nature.com/articles/s43...

The secretome of senescent monocytes predicts age-related clinical outcomes in humans - Nature Aging

Olinger, Banarjee et al. use several proteomic approaches to profile the senescent monocyte secretome and identify senescence-associated circulating proteins that associate with age- and obesity-relat...

nature.com

Your cells can’t digest microplastics, but they can be tricked into spitting them out. Here’s the first evidence that it works in humans. 🧪 jonbrudvig.substack.com/p/first-evid... #microplastics #longevity #sulforaphane

First Evidence of Microplastic Mobilization in a Human Subject – A Self-Experiment

I mobilized millions of microplastics in my blood using a simple supplement protocol. Could this be the key to clearing them from our bodies?

jonbrudvig.substack.com

Aging and disease accelerate when lysosomes fail, and slow down when we fix them. 💊🧪💊 This is an underappreciated, shared mechanism contributing to everything from cellular senescence and #inflammaging to mitochondrial dysfunction and Parkinson's disease.

Metformin became a first-line therapy long before we figured out how—or even where—it actually worked. It turns out the gut, not the liver, is the primary site of action. 🧪 I break down the data on LinkedIn: www.linkedin.com/feed/update/... #Longevity #DrugDevelopment

Metformin became a first-line therapy long before we figured out how—or… | Jon Brudvig, PhD

Metformin became a first-line therapy long before we figured out how—or even where—it actually worked. A few weeks ago, I shared a popular post (below) on metformin’s mechanism of action. The take-h...

linkedin.com

New Bluesky Feed - Longevity! Please like and pin the feed! bsky.app/profile/did:... Moderation List - bsky.app/profile/scie... Allowlist - bsky.app/profile/did:... #longevity #aging #lifeextension #science #gerontology

I appreciate the innovation… but did it have to go on the face? If it does, can we at least make it look like some badass Old English lettering or something? 😅 #Wearables #Longevity #BrainHealth 🧪

Bumping this one for the #Science feed! 🧪

Jon Brudvig@jonbrudvig.bsky.social · last yr.

Reducing exposure is one way to reduce #microplastics. But what about eliminating those already in our bodies? My new self-experiment shows how a simple supplement protocol can stimulate cells to dump internalized microplastics into the bloodstream. Full write up soon. #Longevity #Biohacking

Reducing exposure is one way to reduce #microplastics. But what about eliminating those already in our bodies? My new self-experiment shows how a simple supplement protocol can stimulate cells to dump internalized microplastics into the bloodstream. Full write up soon. #Longevity #Biohacking