World MS Day 30 May 2026 | A day of global solidarity, collective action and hope

Share stories, raise awareness and campaign with everyone affected by multiple sclerosis (MS). The theme for 2024-2026 is diagnosis, support the My MS Diagnosis campaign today. World MS Day is coordin...

worldmsday.org

biorxiv.org

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis

How cancer cells subvert immunity to colonize the lymph node remains unclear. Terasaki et al. uncover that lymph node metastasis may be driven by an immune-to-cancer mitochondria transfer axis that im...

cell.com

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses

INTRODUCTION Microglia are macrophage-like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derive...

alz-journals.onlinelibrary.wiley.com

Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

Abstract. Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However,

academic.oup.com

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology

Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

nature.com

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

JCI - Novel perspectives on extracellular vesicles in autoimmune diseases: immunogenicity, inflammation, and immune surveillance

jci.org

Mitochondrial specialization and signaling shape neuronal function

Neurons are specialized cells designed to process information and transmit it, often across long distances. In many neurons, the axonal volume far exceeds the somato-dendritic volume, creating a need ...

cell.com

Check out ISSCR's society journal, Stem Cell Reports!

invt.io

EMito-Metrix enables automated evaluation of mitochondrial morphology across species - Nature Metabolism

Nature Metabolism - EMito-Metrix enables automated evaluation of mitochondrial morphology across species

nature.com

Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain

The number and diversity of inhibitory neurons (INs) increased substantially during mammalian brain evolution. However, the generative mechanisms of the vast repertoire of human INs remain elusive. We...

science.org

Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer - npj Systems Biology and Applications

npj Systems Biology and Applications - Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer

nature.com

ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

nature.com

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

science.org

Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynami...

elifesciences.org

Mito-nuclear communication: From cellular responses to organismal health

Mito-nuclear communication extends beyond the cell. This review explores how mitochondrial stress engages UPRmt and ISRmt signaling and scales through mitokines and neural circuits to shape systemic p...

cell.com

Mitochondria as sources and targets of cellular signaling

Meichsner et al. review recent insights into mitochondria as dynamic signaling hubs. The authors describe how structural plasticity and interorganellar communication enable mitochondria to serve as bo...

cell.com

Lipoic Acid for Treatment of Progressive Multiple Sclerosis | Neurology

Background and ObjectivesA pilot trial of the antioxidant lipoic acid (LA) in secondary progressive multiple sclerosis (MS) demonstrated a reduction in the whole-brain atrophy, suggesting neuroprotect...

neurology.org

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature

Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

nature.com

Single-cell proteomic landscape of the developing human brain - Nature Biotechnology

Single-cell proteomics maps protein dynamics in the developing human brain.

nature.com

Postdoctoral Research Associate (Fixed Term)

Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced

cam.ac.uk

Postdoctoral Research Associate (Fixed Term)

Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced

cam.ac.uk