#PedSky #MedSky#EpiSky #addictionsci #neuroskyence #neurosci #PainResearch🛟💊🧪 🌍⚖️ Howard Fields was a giant in pain research and treatment at a time the field was literally in the dark ages. By @iasp.bsky.social In Memory of Howard L. Fields

In Memory of Howard L. Fields - International Association for the Study of Pain (IASP)

IASP is deeply saddened to hear of the recent death of Honorary IASP Member, Prof Howard Fields, and we offer our condolences to his family, friends and colleagues. We are […]

iasp-pain.org

We’re hiring! The University of Pittsburgh is recruiting a tenure-track faculty member in pain research to join the Department of Neurobiology and the Pittsburgh Center for Pain Research—an outstanding and highly collaborative community. Please share. More here: cfopitt.taleo.net/careersectio...

Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

$300 Million in jet planes lost to a fuckup. That’s 83 five year NIH R01 grants burned in minutes due to error, aka poor execution of this unnecessary war which serves only to make the world more dangerous.

A video of Alex Pretti reading out the final salute of an unnamed veteran he cared for until the end of his life in the ICU, posted to Facebook by his son.

Here's one I wrote: @washuartsci.bsky.social biologists mapped the "master clock" of our body. 80% sure Professor Erik Herzog and Nikhil are Timelords. 🧠🧪 source.washu.edu/2025/12/mapp...

Mapping the dance of circadian synchrony

Researchers at Washington University in St. Louis have found a way to better track circadian brain signals that synchronize the body clocks.

source.washu.edu

Nothing like a good cry over my morning coffee as Wei heads out 💔. The US is crazy to not do everything possible to keep and treasure people like her. I know she will do wonderful things where ever she lands - this is our loss

Wei Wen@wwenneuro.bsky.social · 11mo ago

After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.

How do you measure brain arousal? In a new study, #ShanahanFellow Ryan Raut uses dynamical systems theory to offer a fresh lens on how physical signs (like pupil dilation), behavior, and brain-wide activity are coordinated. 🧠📈 www.nature.com/articles/s41...

A comprehensive new 🔁 Rreview 🔁 from Dr. Peña explores postnatal maturation of the 🧠 epigenome, the relationship between the epigenome & postnatal sensitive periods & plasticity, and the impact of early-life stress on epigenetic development

Epigenetic regulation of brain development, plasticity, and response to early-life stress

Neuropsychopharmacology - Epigenetic regulation of brain development, plasticity, and response to early-life stress

nature.com

Happy to share our recent work attempting to better understand the impact of early life maternal separation on locus coeruleus function. Super proud of first author (the now Dr.) Chayla Vazquez. She brought this idea when she joined in… March 2020… and she carried it through these rough few years!

Neuropsychopharmacology@npp-journal.bsky.social · last yr.

#ThisWeekInNPP Early life stress profoundly impacts the 🧠 & can result in negative affective behaviors well into adulthood Here, maternal separation stress produced dysregulated noradrenergic activity in the locus coeruleus (LC) across the lifespan, disrupting LC regulation of coping strategies

Some good news. Big congrats to @drbhooma.bsky.social, she is going to do amazing things with this new funding! 🎉

Bhooma Aravamuthan MD DPhil FAAN@drbhooma.bsky.social · last yr.

Excited and proud to report I just received the NoA for an R01 from NINDS investigating cortical targets for treating #dystonia following #preterm birth. Grateful for co-Is Rafael Galindo @washuneurology.bsky.social, @jordacular.bsky.social, and Ream Al-Hasani. Grateful also to my great lab... 1/x

Some good news on a Friday for once, introducing Dr. Chayla Vazquez!

Well, maybe the children will have to live with two cures instead of 30 cures.

University leaders need to understand: they are holding INCREDIBLY good cards. It is so rare in today's polarized era to have the support of 70+ percent of the public against the Trump admiministration on anything. Universities have that—AND winning legal arguments.

PhD Timeline xkcd.com/3081

Bad news for all of us: champion for inclusion & excellence @ NIH/NINDS Dr. Michelle Jones-London is leaving NINDS.💔 She helped launch the career of countless cutting-edge neuroscientists & set the standard for training. Great news of course for where ever she goes next. 🧪🧠@jeremymberg.bsky.social

Leaving behind a generation of biomedical researchers will not MAG nor H.

Scott Delaney@scott-delaney.bsky.social · last yr.

The latest NIH grant chaos: NIH apparently sent stop-work orders to all *97* MARC and U-RISE programs in the country. These programs support underrepresented undergrads interested in health research careers. MARC dates to 1977. Over 48 years, the programs have supported thousands of students.

🚨 New paper out! 👉A #systematicreview and #metaanalysis on the impact of neuropathic #pain models on anxiety- and depressive-like behaviors in rodents. #CIBER_SAM #univcadiz #INiBICA_IIS #OpenAccess Read more here ⬇️ doi.org/10.1016/j.bp...

Science Under Threat in the United States The NIH is a sound investment for the US taxpayer By my colleague Nicholas W Gilpin from Louisiana who has written this piece in his personal capacity due to the current institutional situation. elifesciences.org/articles/106...

Science Under Threat in the United States: The NIH is a sound investment for the US taxpayer

Research funded by the National Institutes of Health is essential for improving the health of Americans and developing new drugs and treatments for a wide range of diseases.

elifesciences.org

It feels like the resumption of study section posting on the federal registrar, while continuing to block advisory council, was an attempt to quell the news cycle while still keeping funds frozen.

These terminations are a disgusting abuse of power that threatens the future of American science. 💔

Jeremy Berg@jeremymberg.bsky.social · 2y ago

I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia. This is quite damaging to research and to individuals. This is pure terrorism and cannot be legal. But litigation will take time...

New work from the lab published at @cp-neuron.bsky.social. In this study we dissect the role of hormonal regulation in pain-induced enhanced opioid intake in males. Work conducted by the super talented @jessinbotham www.cell.com/neuron/fullt...

Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males

Higginbotham et al. show that inflammatory pain increases opioid-evoked dopamine neuron activity to promote fentanyl use selectively in males. Ovarian hormones offer females protection, but estradiol’...

cell.com

Thanks to @danai-lama.bsky.social for covering our preprint. I missed this when she posted it and now this place seems mostly for doomscrolling, so it’s nice to have our science highlighted to at least momentarily disrupt the gloom 💙

Danai Riga@danai-lama.bsky.social · 2y ago

Starting *Week 1* with this gem from the @jordacular.bsky.social lab, describing a novel glutamatergic pathway from the VTA to the LC that is involved in avoidance behaviors. 2/ pmc.ncbi.nlm.nih.gov/articles/PMC...

More of this please.

Jeremy Berg@jeremymberg.bsky.social · 2y ago

Compelling pushback from @jmgrohneuro.bsky.social and the Board of Scientific Counselors at the National Institute on Mental Health (NIMH) regarding termination of tenure-track investigators driven by DOGE. 1/2

St. Louis @standupforscience.bsky.social This Friday!!! And, if you're on the west side of the state, head to the Jefferson City event! Noon Friday.

As someone who has spent the last 25 years studying sex differences in brain function and behavior and the last 10 advocating (loudly) for SABV and working to help my colleagues implement the policy into their work, this is utterly heartbreaking.

Dr. Becca@docbecca.bsky.social · 2y ago

Great write up at @thetransmitter.bsky.social on the seeming erasure of SABV in the new era of NIH. Gotta say The Transmitter is killing it the last few weeks, first to report on the Federal Register block and now this. Leading the charge! 💪 www.thetransmitter.org/policy/exclu...

Sadly true. Also expect that anything you have put in eRA Commons, NIH’s central grant application and review repository, will be used to train Musk’s AI. We should start asking Grok “what research work is <X NIH grant applicant> proposing to do” and see when confidential info starts popping up. 🧪

Anne Carpenter@drannecarpenter.bsky.social · 2y ago

Probably worth downloading Notices of Grant Awards or anything else you’d like to keep a permanent record of from ERA Commons.

Jonah and I still trying to figure out this whole bsky thing, but important psychedelic imaging work here with Josh Siegel & Adam Bauer!

We found a psychedelic (DOI) altered neurovascular coupling and differential changed neuronal ⚡📉vs hemodynamic 🩸📈 brain activity 🧠. These findings have grand implications for interpretation of psychedelic fMRI. @jordacular.bsky.social www.biorxiv.org/content/10.1... Read more below!