Mechanism of nucleolytic degradation of human ribosomes https://www.biorxiv.org/content/10.64898/2026.04.26.720784v1

Really great work showing how LARP1 senses 40S levels to regulate TOPs www.biorxiv.org/content/10.6...

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

A Preoptic Neurocircuit That Modulates Metabolic Flexibility https://www.biorxiv.org/content/10.64898/2026.01.15.699760v1

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)

mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth

MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...

biorxiv.org

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

mRNA poly(A)-tail length is a battleground for coronavirus–host competition

Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...

biorxiv.org

Check out the latest work from Jordan Ray (@jordanray.bsky.social), a collaboration between our lab and David Sabatini’s lab. www.biorxiv.org/content/10.1... (1/2)

Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation

Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...

biorxiv.org

I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation

Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...

biorxiv.org

Are u tired of reading about tariffs? Then take a look to our last work! @science.org www.science.org/doi/10.1126/...

Retromer promotes the lysosomal turnover of mtDNA

Lysosomal uptake of mtDNA controls mitochondrial quality.

science.org

Very cool. www.science.org/doi/10.1126/...

Exogenous RNA surveillance by proton-sensing TRIM25

Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

science.org

Don’t miss this Q&A with Dr. Michelle Frank (@michelle-frank.bsky.social), an awesome postdoc in our lab!

Whitehead Institute@whiteheadinstitute.bsky.social · last yr.

Our latest Postdoc Q&A features Michelle Frank from the Bartel lab. Michelle is interested in how the brain balances the ability to learn new things with the need for maintaining stable connections. wi.mit.edu/news/meet-wh... #WhiteheadPostdocProfiles @bartellab.bsky.social

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Jeremy Berg@jeremymberg.bsky.social · last yr.

F mechanisms (New and Competitive renewals) Oof! 3/n

Pleased to share my recent work from the Bartel Lab! Some miRNAs recognize novel target sites called 3'-only sites, which pair to the miRNA 3' region but not to the seed. These sites direct mRNA repression in cells and are engaged by different mechanisms to seed sites www.biorxiv.org/content/10.1...

Functional microRNA targeting without seed pairing

MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to serve as guides, directing binding to partially complementary sites in mRNAs, ultimately causing post-transcriptional repression. Compleme...

biorxiv.org

We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!

bioRxivpreprint@biorxivpreprint.bsky.social · 2y ago

Lysosomal reduced thiols are essential for mouse embryonic development https://www.biorxiv.org/content/10.1101/2024.12.26.630348v1

Bartel Lab bids a fond farewell to our incredible lab manager, Asia Stefano. Wishing you all the best on your new adventures in the Rocky Mountains, Asia—thank you for the amazing time we shared together!

If you've been meaning to check out the Night Science Podcast, this is the perfect episode to get started with. Everyone is telling me it's our best one yet!

www.cell.com/cell/fulltex... Quite a cool novel role for a snoRNA. I am curious how the structured domain of the SRP RNA becomes accessible for snoRNA73 binding and if this would disrupt SRP19 binding to the SRP RNA.

snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification

Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions, which facilitate nascent protein translocation to the ER and subsequent secretion.

cell.com