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@joseruizlab.bsky.social

56 Posts165 Follower113 Folgt
@joseruizlab.bsky.social · 5mo ago

Great to see our recent work published! Many thanks to Brabec’s group for this fruitful collaboration, and congratulations to my former PhD student @antoniolinero.bsky.social for the excellent contributions. Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...

Novel 2-(2′-Benzothiazolyl)-benzimidazole-Based Iridium(III) Photocatalysts Exhibit Antiproliferative Effects in 2D and 3D Cancer Cells to Bypass Hypoxia-Induced Resistance

This study explores the therapeutic potential of seven bis-cyclometalated Ir(III) complexes (1–7), derived from the 2,2′-(benzothiazolyl)benzimidazole scaffold, as highly promising next-generation pho...

pubs.acs.org

@joseruizlab.bsky.social · 6mo ago

Thrilled to share our latest collaboration with @kargesgroup.bsky.social! Huge congrats to @antoniolinero.bsky.social & all co-authors, including @nmontesdeocas.bsky.social. Exciting advances in photoactivated iridium nanomaterials & oncosis‑driven cancer cell death. doi.org/10.1021/acsa...

Encapsulation of a Cyclometalated Iridium(III) Photosensitizer into Nanosized Micelles for Oncosis-Inducing Photodynamic Therapy

The reliance of many anticancer agents on apoptosis often limits their therapeutic efficacy and contributes to the development of drug resistance. To overcome these challenges, alternative mechanisms ...

doi.org

@joseruizlab.bsky.social · 8mo ago

🎉A great way to close 2025. Fantastic collaboration with @MarchanLab_UB and all co‑authors. ”Novel Heteroleptic Iridium(III) Complexes Containing COUBPY Ligands for Effective Photoinduction of Ferroptosis for Cancer Therapy | JACS Au

Novel Heteroleptic Iridium(III) Complexes Containing COUBPY Ligands for Effective Photoinduction of Ferroptosis for Cancer Therapy

Ferroptosis, a recently described form of regulated, nonapoptotic cell death mechanism, presents significant potential for cancer treatment, particularly when combined with photodynamic therapy (PDT)....

pubs.acs.org

@joseruizlab.bsky.social · 8mo ago

🎓✨ Excellent PhD defense by Carla Hernando on functional naphthalimide luminogens at the University of Burgos, supervised by Prof. Tomás Torroba. Honored to serve on the committee with Silvia Albillos and Joaquín Campos. Congratulations, Carla, on a brilliant presentation! 👏

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@joseruizlab.bsky.social · 9mo ago

📢 Lecture at the Faculty of Chemistry (UMU) 👤 Dr. Johannes Karges (Ruhr-University Bochum, Germany) 📅 November 27 Organized by: Grupo Metalofármacos | PhD Program in Basic & Applied Chemistry Co-financed by: Master in Fine & Molecular Chemistry 👉 Don’t miss it! #UMU #Chemistry #Lecture

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Gasser Group@gassergroup.bsky.social · 9mo ago

Thrilled to share our article just published in @J_A_C_S on the selection of Ru-modified aptamers! Fantastic collaboration with @hollensteinlab.bsky.social, congratulations to all authors! doi.org/10.1021/jacs...

Selection of Ruthenium Polypyridyl Complex-Modified Aptamers for Photodynamic Therapy against Streptococcus Pneumonia

Photodynamic therapy (PDT) harnesses the combination of light, oxygen, and photosensitizers to induce cell death via reactive oxygen species (ROS) formation. Given its intrinsic properties, PDT repres...

doi.org

@joseruizlab.bsky.social · 10mo ago

Congratulations Gloria! A fantastic Feature Article on Type I photorreactivity in Ir/Ru complexes - great to see in @chemcomm.rsc.org. Kudos to @MarchanLab_UB, & teams led by Brabec, Sastre, @gassergroup.bsky.social, @kargesgroup.bsky.social, Nonell, Frances, @eortegaforte.bsky.social

Gloria Vigueras@viguerasgloria.bsky.social · 10mo ago

Happy to share that our Feature Article has just been accepted in @chemcomm.rsc.org !🎉 We explore Type I photoreactivity in cyclometalated Ir/Ru complexes. Proud to be corresponding author 💡 @joseruizlab.bsky.social @Marchanlab pubs.rsc.org/en/content/art…

@joseruizlab.bsky.social · last yr.

Happy to see the new paper from our great collaboration with @kargesgroup.bsky.social on #PDT, #Iridium and #HSA conjugation! Thanks to all-coauthors & also to @ruhr-uni-bochum.de, @UMU & @AEI

Karges Group@kargesgroup.bsky.social · last yr.

Check out our paper in @inorgchemfront.rsc.org about the Induction of Oncosis by Light Activation with an Ir(III) complex conjugated to Albumin. Congrats to Antonio, Zisis, and Lisa. Fantastic collaboration with @joseruizlab.bsky.social ! @ruhr-uni-bochum.de @um.es dx.doi.org/10.1039/D5QI...

@joseruizlab.bsky.social · last yr.

Glad to share our last studies in collaboration with Viktor Brabec. Photoactivatable Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors | ACS Pharmacol & Transl Science pubs.acs.org/doi/full/10....

Photoactivatable Cyclometalated Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors

The blood-brain barrier represents a significant challenge in delivering anticancer drugs for glioblastoma treatment. The study investigates the potential of a series of octahedral photoactivatable cyclometalated iridium complexes (Ir1–Ir10) with the general formula [Ir(ttpy)(C∧N)Cl]PF6 as photoactivated therapy candidates for the treatment of this aggressive tumor. These complexes, which include the terdentate ligand 4′-(p-tolyl)-2,2′:6′,2″-terpyridine (ttpy), and a C∧N ligand based on the deprotonated 2-arylbenzimidazole backbone, were tested on human glioblastoma using 2D cell cultures and 3D spheroidal models, including a fusion system comprising cerebral organoids from nonmalignant human-induced pluripotent stem cells and spheroids derived from malignant brain cells. The iridium complexes catalyze NADH photooxidation and photogenerate 1O2 and/or •OH under blue light irradiation. Blood-brain barrier penetration was assessed using various in vitro models. The complex Ir4, containing deprotonated methyl 1-butyl-2-phenylbenzimidazolecarboxylate, shows promise for targeted therapy of resistant brain tumors when photoactivated with blue light. Ir4 induces rapid and sustained ROS-mediated cytotoxicity and selectively accumulates in tumor tissue. This suggests its potential for fluorescently guided-PDT cooperative resection of glioblastoma. Notably, Ir4 significantly reduces glioblastoma growth even under dark conditions compared to conventional Temozolomide treatment without affecting healthy brain tissue.

pubs.acs.org

@joseruizlab.bsky.social · last yr.

Glad to participate in this interesting review in @inorgchemfront.rsc.org . Thank you to all the co-authors. Great collaboration with @MarchanLab_UB.

Gloria Vigueras@viguerasgloria.bsky.social · last yr.

🚨 Our review "Metal–Coumarin Derivatives as Promising Photosensitizers" is now published in @inorgchemfront.rsc.org! Huge thanks to @joseruizlab.bsky.social and all co-authors! 🔗https://pubs.rsc.org/en/Content/ArticleLanding/2025/QI/D5QI00858A #OpenAccess #PDT #HOTarticles

Oliver Wenger@wengeroliver.bsky.social · last yr.

A simple guide to the design of metal complexes in luminescence and photoredox catalysis. With Giacomo Morselli and Christian Reber in JACS @jacs.acspublications.org pubs.acs.org/doi/10.1021/...

Molecular Design Principles for Photoactive Transition Metal Complexes: A Guide for “Photo-Motivated” Chemists

Luminescence and photochemistry involve electronically excited states that are inherently unstable and therefore spontaneously decay to electronic ground states, in most cases by nonradiative energy release that generates heat. This energy dissipation can occur on a time scale of 100 fs (∼10–13 s) and usually needs to be slowed down to at least the nanosecond (∼10–9 s) time scale for luminescence and intermolecular photochemistry to occur. This is a challenging task with many different factors to consider. An alternative emerging strategy is to target dissociative excited states that lead to metal–ligand bond homolysis on the subnanosecond time scale to access synthetically useful radicals. Based on a thorough review at the most recent advances in the field, this article aims to provide a concise guide to obtaining luminescent and photochemically useful coordination compounds with d-block elements. We hope to encourage “photo-motivated” chemists who have been reluctant to apply their synthetic and other knowledge to photophysics and photochemistry, and we intend to stimulate new approaches to the synthetic control of excited state behavior.

pubs.acs.org

Universidad de Castilla-La Mancha@uclm.es · last yr.

La UCLM lamenta el fallecimiento de Félix Jalón Sotés, quien fuera catedrático de Química Inorgánica y director del Instituto Regional de Investigación Científica Aplicada (IRICA) La imagen recoge el homenaje que le dio la Facultad de Ciencias y Tecnologías Químicas el pasado mes de diciembre.

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@joseruizlab.bsky.social · last yr.

Glad to participate in this paper. Great collaboration with @kargesgroup.bsky.social congrats @antoniolinero.bsky.social & Lisa!

Karges Group@kargesgroup.bsky.social · last yr.

Check out our article in J. Med. Chem. @acsmedi.bsky.social about the Rational Design of an Ir(III) Complex with Exceptionally Strong Human Serum Albumin Binding for Photodynamic Therapy. Congrats to Antonio & Lisa! Wonderful collaboration with @joseruizlab.bsky.social ! pubs.acs.org/doi/full/10....