Joyce Valadares
@joycevaladares.bsky.social
PhD researcher at the MRC MBU, University of Cambridge, studying cardiac metabolism during IR injury.
Congrats to Laura Pala and Hiran Prag on their new paper in Cardiovascular Research. doi.org/10.1093/cvr/...
Mitochondrial succinate transport is required for cardiac ischaemia/reperfusion injury
AbstractAims. Succinate accumulates significantly during myocardial ischaemia, and its rapid oxidation upon reperfusion is a critical driver of ischaemia/r
doi.org
Excited to share that at the annual MRC MBU symposium I was awarded best poster prize for my PhD project on Succinate Metabolism in Cardiac Ischemia/ Reperfusion Injury! Thanks to my lab, collaborators, and my PI Mike Murphy. @mitoredox.bsky.social
Great to see paper from Alva Casey out today in Nature Metabolism - from her PhD. Well done Alva! doi.org/10.1038/s422...
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature Metabolism
Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.
doi.org