Mike Murphy
@mitoredox.bsky.social
Our lab is interested in all things mitochondrial.
Congrats to Evanna Mills on the first paper from her lab! Many more to come... www.nature.com/articles/s42...
Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis - Nature Metabolism
Tang et al. reveal that macrophage-derived itaconate acts as a paracrine inhibitor of adipose tissue thermogenesis by blocking succinate uptake into brown adipose tissue.
nature.com
I have two post doctoral positions available in my lab funded by the Wellcome Trust to develop new chemical biology approaches to studying mitochondria. Would suit those with interest in both mitochondria and chemical biology. Advert below-please forward and repost! www.cam.ac.uk/jobs/researc...
Research Associate x 2 (Fixed Term)
The Medical Research Council Mitochondrial Biology Unit (MRC MBU), University of Cambridge, wishes to appoint two post-doctoral Research Associates to join the research group of Prof. Mike Murphy at t...
cam.ac.uk
Very pleased to have presented the Keith Reimer Distinguished Lecture at the ISHR meeting in Birmingham this week. Recognition of the work we have done with Thomas Krieg over the past 15 years
Congrats to Laura Pala and Hiran Prag on their new paper in Cardiovascular Research. doi.org/10.1093/cvr/...
Mitochondrial succinate transport is required for cardiac ischaemia/reperfusion injury
AbstractAims. Succinate accumulates significantly during myocardial ischaemia, and its rapid oxidation upon reperfusion is a critical driver of ischaemia/r
doi.org
Congrats to Patrick Cardwell on his paper that covers his PhD work - another great collaboration with the Richard Hartley lab. doi.org/10.1016/j.ej...
Redirecting
doi.org
Congrats to Dunja on her latest paper just out in Nature Cardiovascular Research! doi.org/10.1038/s441...
Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy - Nature Cardiovascular Research
Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.
doi.org
At Keystone enjoying some mitochondrial science and catching up with friends www.keystonesymposia.org/conferences/...
Mitochondria Signaling in Physiology and Disease | Keystone Symposia
Join us at the Keystone Symposia on Mitochondria Signaling in Physiology and Disease, February 2026, in Keystone, with field leaders!
keystonesymposia.org
Funding? I'm a simple academic, so I'll have to await someone smart to explain to me how "pausing" MRC and BBSRC funding is the action of a biomedical science superpower...?
Congrats to Jan whose new paper on persulfide measurement is is out now in Nature Comms
Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy. doi.org/10.1038/s441...
Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia - Nature Cardiovascular Research
Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...
doi.org
Congrats to Emma Yu on her new paper on Tafazzin! doi.org/10.1038/s414...
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models - Nature Communications
Atherosclerosis is the leading cause of death worldwide. Here, the authors show that defective vascular smooth muscle cell tafazzin promotes mitochondrial dysfunction and atherosclerosis, highlighting...
doi.org
Pleased to be a small part of a recent paper led by Thiru Kanneganti at St Judes www.cell.com/cell/fulltex...
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...
cell.com
Congrats to Kath Hammond who was awarded a short talk prize at the recent WT "Mitochondrial medicine: therapeutic development" meeting at Hinxton.
Excited to share that at the annual MRC MBU symposium I was awarded best poster prize for my PhD project on Succinate Metabolism in Cardiac Ischemia/ Reperfusion Injury! Thanks to my lab, collaborators, and my PI Mike Murphy. @mitoredox.bsky.social
Drs Cherrie Kong and Stephen Harmer (University of Bristol) are offering a fully funded PhD project, " For information and to apply: www.findaphd.com/phds/project.... For information including application preparation: cherrie.kong@bristol.ac.uk Application deadline: 15 December 2025
Understanding and slowing transverse tubule loss in heart failure at University of Bristol on FindAPhD.com
PhD Project - Understanding and slowing transverse tubule loss in heart failure at University of Bristol, listed on FindAPhD.com
findaphd.com
Congrats to Nils Burger who is just starting his lab at UTSW in Texas! Any prospective PhD students or post-docs should get in touch with Nils. www.nils-burger-lab.com
Burger Lab @ UTSW
The Burger Lab Defining the metabolite protein regulome
nils-burger-lab.com
In Toronto today giving a seminar at the Sick Kids Research Institute on "Mitochondria in Ischemia-Reperfusion Injury: From Basic Science to Potential Therapies" Great to catch up with previous lab member now in Toronto - Thomas Hurd, Ellen Robb and Anna Dare.
Great to see this paper out - another Krieg/Murphy collaboration - and congratulations to Jordan Lee who did most of the work! academic.oup.com/cardiovascre...
Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke
AbstractAims. Ischemic stroke is increasingly treated by mechanical thrombectomy (MT) with the more rapid and complete reperfusion of the ischemic tissue,
academic.oup.com
Great to see Hiran Prag setting up his lab at the University of Manchester - I'm expecting great things! personalpages.manchester.ac.uk/staff/hiran....
Prag Lab - Coming Soon
personalpages.manchester.ac.uk
It was wonderful to see the NEJM paper today about healthy babies born free of mtDNA disease following mitochondrial donation. Built on decades of work led by Doug Turnbull and his team in Newcastle. www.nejm.org/doi/full/10....
Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease | NEJM
Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc...
nejm.org
It was a great pleasure to attend last week Professor Dunja Aksentijevic's inaugural Professorial Lecture at Queen Mary, University of London. Dunja, it's just the start!
Congrats to Helena Cocheme @cochemelab.bsky.social on her paper on redox regulation of autophagy in Drosophila. doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
Good day yesterday at the William Harvey Research Institute Research Day where I was honoured to receive the Derek Willoughby Medal and give a lecture. Great hospitality from Dunja Aksentijevic and Sir Mark Caulfield.
Series of interesting papers showing that haematopoietic stem cells can undergo damaging clonal haematopoiesis when they acquire mutations that enhance mitochondrial respiration - opening the way to using metformin - and my beloved MitoQ - to prevent this transition. doi.org/10.1038/s415...
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis - Nature
Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid le...
doi.org
By the Atlantic in Galway at the SFRRI meeting - catching up with old friends and new. www.sfrrgalway2025.com
22nd SFRRI Biennial Meeting I Galway I June 3-6, 2025
Information, Program, Registration, Abstract Submission for the 22nd SFRRI Biennial Meeting
sfrrgalway2025.com
Congrats to Renata Goncalves who led a study in Gokhan Hotamisligil's lab that has just come out in Nature - ably assisted by Jillian Riveros! www.nature.com/articles/s41...
CoQ imbalance drives reverse electron transport to disrupt liver metabolism - Nature
Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty liver dis...
nature.com
Congratulations to Abigail Giles who was awarded the "The Richard J. Bing Award for Young Investigators" at the recent World Congress of the International Society For Heart Research in Japan. Well done Abigail!
Congratulations to @clarebryant.bsky.social on her election to the Academy of Medical Sciences!
