Joao Pedro Magalhaes
@jpsenescence.bsky.social
Scientist decoding the aging genome, professor, geek, entrepreneur, speaker, writer, keen footballer.
Embracing non-linearity in human ageing www.nature.com/articles/s41...
Embracing non-linearity in human ageing - Nature Reviews Genetics
Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such e...
nature.com
Rejuvenation Potential of Developmental Genes Downregulated in Aging www.ijstemcell.com/journal/view...
Rejuvenation Potential of Developmental Genes Downregulated in Aging
Byungkuk Min, Juhyeon Nam, Minseo Choi, Junyoung Hong, Areum Baek, Janghwan Kim. IJSC -0001;0:. https://doi.org/10.15283/ijsc25144
ijstemcell.com
I'm delighted to be speaking at the Longevity Summit Portugal 2026 on 18 September in my hometown of Porto. Looking forward to discussing the latest advances in longevity science and meeting colleagues from across the scientific and medical communities. lp.centroinovacaomedica.pt/cim-longevit...
Genomic, epigenomic and transcriptomic regulation of cellular senescence www.nature.com/articles/s41...
Genomic, epigenomic and transcriptomic regulation of cellular senescence - Nature Reviews Genetics
Senescence — a complex, dynamic and heterogeneous stress-responsive cell state — shapes ageing biology and tissue homeostasis. This Review examines the molecular regulation of senescence initiation, m...
nature.com
Spike-in-normalised single-cell RNA-seq reveals cell-type-specific transcriptional repression during ageing www.biorxiv.org/content/10.6...
Spike-in–normalised single-cell RNA-seq reveals cell-type-specific transcriptional repression during ageing
Transcriptome analyses are widely used for biomarker discovery and to gain insights into normal processes and diseases. Age-related changes in gene expression inferred from RNA-seq are typically repor...
biorxiv.org
Excited to share my perspective on the hyperfunction theory of aging. Mikhail Blagosklonny (1961-2024) proposed that aging is "a continuation of the developmental program that is not turned off." I hope to honour his contributions. www.aging-us.com/article/2064...
A brief history of the hyperfunction theory of aging and future directions | Aging
Aging remains a mystery of biology, and debate regarding why we age has been ongoing for centuries. Many theories of aging have been proposed, most of which focus on errors and the gradual accumulati
aging-us.com
Always awesome to attend Foresight Institute events 🚀 My talk at Vision Weekend in London is now online. www.youtube.com/watch?v=vSsw...
João Pedro de Magalhães | Hacking Aging Biology @ Vision Weekend UK 2026
YouTube video by Foresight Institute
youtube.com
Putin’s £20bn quest to live FOREVER is both 'sinister & comic' as 'evil' trio discuss immortality www.youtube.com/watch?v=PbZI...
Putin’s £20bn quest to live FOREVER is both 'sinister & comic' as 'evil' trio discuss immortality
YouTube video by The Sun
youtube.com
Hiding in plain sight: uncovering the genetic basis of complex phenotypes through low-risk groups academic.oup.com/genetics/adv...
Hiding in plain sight: uncovering the genetic basis of complex phenotypes through low-risk groups
Abstract. Medical genetic studies focus on high-risk groups to enrich for targeted phenotypes. Although genetic effects may vary across the lifespan, age-r
academic.oup.com
Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis link.springer.com/article/10.1...
Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis - BMC Biology
Background Aging is accompanied by widespread transcriptional remodeling across tissues, yet how aging impacts different categories of tissue-resident macrophages is not well understood. Macrophages a...
link.springer.com
A university once took so long to approve my request for a new laptop that, by the time I could finally order it, the model had been discontinued. What's the most absurd bureaucratic experience you've had in academia?
Combating ageing beyond the cell: Emerging roles of extracellular proteostasis febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well unders...
febs.onlinelibrary.wiley.com
SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program link.springer.com/article/10.1...
SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program - The EMBO Journal
Identifying senescent cells via single-cell transcriptome profiling data remains challenging due to cellular heterogeneity and overlap with other cellular states. Here, we present SenFlag, a streamlin...
link.springer.com
Escape and evasion: when immunosurveillance of senescent cells goes wrong www.frontiersin.org/journals/gen...
Frontiers | Escape and evasion: when immunosurveillance of senescent cells goes wrong
Aging involves molecular changes that can give rise to different cell fates, one of those being cellular senescence. Senescent cells stably arrest in the cel...
frontiersin.org
Excited to start as a Visiting Academic at @ucl.ac.uk ! Looking forward to collaborations and discussions with colleagues across UCL and beyond. If you're at UCL or in London, I'd love to connect and explore potential collaborations.
Indirect genomic effects shape cancer risk across species www.biorxiv.org/content/10.6...
Indirect genomic effects shape cancer risk across species
Tumour prevalence varies dramatically throughout the animal kingdom despite broadly conserved cellular and developmental processes, raising the question of how evolution has shaped susceptibility [1][...
biorxiv.org
Diapause provides strong evidence that aging is not simply wear and tear but is regulated by genome-encoded developmental programs 🧬 At least in some animals, aging is governed by a genetic program whose software can be decoded and perhaps even rewritten.
Aging Science News@agingbiology.bsky.social · last mo.Diapause presses pause on life’s developmental and ageing clock www.nature.com/articles/s41...
Network-driven discovery of repurposable drugs targeting hallmarks of aging www.nature.com/articles/s43...
Network-driven discovery of repurposable drugs targeting hallmarks of aging - Nature Aging
The authors introduce a network medicine framework showing that the hallmarks of aging form interconnected molecular modules in the human interactome. This new approach can help to identify existing d...
nature.com
Mechanisms and Evolutionary Advantages of Unlimited Reproductive Lifespans in Naked Mole-Rat Queens www.annualreviews.org/content/jour...
Mechanisms and Evolutionary Advantages of Unlimited Reproductive Lifespans in Naked Mole-Rat Queens
The naked mole-rat (Heterocephalus glaber) defies mammalian norms with lifelong fertility and postnatal oogenesis. Unlike most mammals, which experience reproductive senescence due to depletion of a f...
annualreviews.org
Have we been looking at RNA changes during ageing the wrong way? 🧬 In our new study, we use a largely overlooked technique called spike-in normalisation to investigate age-related changes in transcripts across mouse cell types. www.biorxiv.org/content/10.6...
Spike-in-normalised single-cell RNA-seq reveals cell-type-specific transcriptional repression during ageing
Transcriptome analyses are widely used for biomarker discovery and to gain insights into normal processes and diseases. Age-related changes in gene expression inferred from RNA-seq are typically repor...
biorxiv.org
Social insects are an excellent example of how the genome regulates lifespan 🐜 🐝 In Harpegnathos ants, when a queen dies, some workers undergo a caste switch to reproductive pseudo-queens and live up to 5× longer 🤯 This supports the idea that aging is a genetically-regulated process 🧬
Aging Science News@agingbiology.bsky.social · last mo.A Lineage-Specific Peptide Suppresses Juvenile Hormone to Drive Reproductive and Longevity Reprogramming in Ants www.biorxiv.org/content/10.6...
Why we age – Integrating error, program, and selective pressure www.sciencedirect.com/science/arti...
Why we age – Integrating error, program, and selective pressure
Whether aging arises primarily from the progressive accumulation of molecular damage (error-based theories) or from regulated, development-related pro…
sciencedirect.com
AI is not trained in biology, it is trained on human interpretations of biology. As such, it carries our biases, knowledge gaps, and misunderstandings. Great to discuss the impact of AI in biology and geroscience in beautiful Coimbra.
Maternal senescence broadly reprograms gene expression in offspring www.biorxiv.org/content/10.6...
Maternal senescence broadly reprograms gene expression in offspring
Offspring of older parents have reduced fitness in many species, but the mechanisms mediating this cross-generational dimension of ageing remain poorly understood. Senescence is associated with genome...
biorxiv.org
Jumping the clock: Engineering ageing in biomedicine www.cell.com/trends/biote...
Jumping the clock: Engineering ageing in biomedicine
Engineering the age(ing) of tissues in vitro could lead to more representative and predictive models for the ageing population. This forum introduces methodological approaches for ‘age engineering’ (‘...
cell.com
REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect journals.plos.org/plosone/arti...
REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect
Background Ageing is associated with reduced resilience to physiological stressors such as infection and surgery. This reduced resilience is believed to be underpinned by the hallmarks of ageing, the ...
journals.plos.org
Another fantastic GRC Systems Aging conference comes to a close in Maine, USA. Thank you and congratulations to the chair and vice-chairs for organizing another incredible event, with outstanding science, networking, and discussions. My favourite conference in the field!
New paper on gene therapies in longevity and aging 🧬 We discuss recent advances and remaining challenges in gene therapies for aging, highlighting promising targets, delivery strategies, and approaches to cellular rejuvenation. www.sciencedirect.com/science/arti...
sciencedirect.com
Taking apart the DNA-methylation clock with an epigenetic progeria syndrome www.nature.com/articles/s41...
Taking apart the DNA-methylation clock with an epigenetic progeria syndrome - Nature Genetics
With advancing age, clock-like DNA-methylation changes occur across the genome. Whether these changes are passenger events or drive pathology remains to be determined. Here we report a novel epigeneti...
nature.com
