New preprint from the lab 🥳 We made new knock-in zebrafish 🐟 that fluorescently tag endogenous neurofascins. So now, we can live-image neuronal nfasca/NF186 and glial nfascb/NF155 non-invasively, as nerves, nodes of Ranvier and paranodes develop in vivo 🧵👇 www.biorxiv.org/content/10.6...

Live-imaging of endogenous neurofascins reveals glial adhesion shapes developing nodes of Ranvier

The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuronal and glial cell-adhesion molecules, including n...

biorxiv.org

Excited to share my postdoc paper from the @lyons-lab.bsky.social Our question: what controls axon diameter? It varies >100-fold between neurons, shapes signal speed & myelination, and changes in disease. Yet very little is known about what regulates it. 🧵 journals.plos.org/plosbiology/...

A high-resolution phenotypic screen identifies regulators of CNS axon diameter in zebrafish

Axon diameter is important for action potential conduction speed, but what molecular pathways influence this neuronal property? This study reports a high-resolution imaging-based chemical screening pi...

journals.plos.org

Huge congratulations to @nadinebc.bsky.social!!! :)

@nadinebc.bsky.social · 4mo ago

Last week I successfully passed my viva 🎓! It was a pleasure to discuss the work with @aidarodrigo.bsky.social, @bayraktarlab.bsky.social and @willmacnair.bsky.social, and to celebrate with the lab @annawilliamslab.bsky.social (thanks for this amazing single-cell hat!)

Thrilled that our paper is now published. It’s been a real privilege to work on this project together with co-first author @ara-donia.bsky.social, under the supervision of @lyons-lab.bsky.social, and with such an outstanding team in Edinburgh and internationally! www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

science.org

Thanks to the organisers and everyone who contributed to a fantastic Edinburgh zebrafish research retreat! 🐟🔬⛰️🚣‍♀️

A wonderful opportunity to talk at the Cambridge Centre for Myelin Repair - Thanks for having us!

Rana Fetit@ranafetit.bsky.social · last yr.

Great talks by @rebeccakssmith.bsky.social, @martina-m.bsky.social and @juliavdkorput.bsky.social from our @annawilliamslab.bsky.social lab about oligodebdrocytes, myelin and disease heterogeneity at the Cambridge Centre for Myelin Repair held at @cambridgeuni.bsky.social

Congratulations Phil!!

@lyons-lab.bsky.social · last yr.

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...

First post at this side. Latest axon diameter action led by Jenea Bin, in collaboration with Nolan, Mobius, Monk, Werner, and Emery labs. www.biorxiv.org/content/10.1...

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes

Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linea...

biorxiv.org

Two fantastic papers were published today in @NatureNeuro highlighting some major advances in understanding MS using spatial transcriptomics 🧬 I feel very lucky to have the chance to write a News & Views article about them! ⭐️ Read it here: rdcu.be/dY9Hk

Mapping out multiple sclerosis with spatial transcriptomics

Nature Neuroscience - In this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growing possibilities of spatial transcriptomics by...

rdcu.be

My first first author paper is out! doi.org/10.3390/gene... Main message: 💸 Less expensive sequencing methods can provide just as good quality single-cell data 📊 With David A. D. Munro, Meryam Beniazza, Josef Priller, @annawilliamslab.bsky.social, Andrea Corisnotti