Tessera

@lyons-lab.bsky.social

Latest offering. How myelin ensheathes axons! Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths. Driven forward by Cody Call, Kelly Monk, and myelin folks @edinburgh-uni.bsky.social Enjoy! www.nature.com/articles/s41...

Flexible ensheathment of axons enables myelination of complex CNS networks - Nature

The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide&nbsp...

nature.com

Julia van de Korput @juliavdkorput.bsky.social · 6mo ago

Thrilled that our paper is now published. It’s been a real privilege to work on this project together with co-first author @ara-donia.bsky.social, under the supervision of @lyons-lab.bsky.social, and with such an outstanding team in Edinburgh and internationally! www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

science.org

@ara-donia.bsky.social · 6mo ago

I am delighted to see this work published. A big thanks to everyone, particularly the excellent supervision of @lyons-lab.bsky.social, the work of co-first author @juliavdkorput.bsky.social and wonderful collaborators in Amsterdam and Oregon. www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel

science.org

@lyons-lab.bsky.social · 6mo ago

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social Huge team effort, with immense contributions by friends from nearby and around the globe. www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel

science.org

Jenn Orthmann Murphy @jennoligomyelin.bsky.social · 6mo ago

alert! fundamental myelin biology - led by the amazing Yevgeniya Mironova and Dwight Bergles www.science.org/doi/10.1126/...

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors

Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...

science.org

UK Dementia Research Institute @ukdri.ac.uk · 8mo ago

Very excited to share the news today that Professor Baljit Khakh will become the new Centre Director of the UK DRI at Cardiff University! Read our full announcement 👉 www.ukdri.ac.uk/news-and-eve...

Prof Khakh quote - I hope to make a meaningful difference to the lives of people affected by dementia by advancing new therapeutic mechanisms grounded in fundamental neuroscience, and by helping to build a research environment where great science and great scientists can thrive.

@lyons-lab.bsky.social · 9mo ago

Led by Marcus Keatinge "Mislocalisation of TDP-43 to the cytoplasm of either neurons or oligodendrocytes causes axonopathy and dysmyelination" www.biorxiv.org/content/10.1...

biorxiv.org

Institute for Regeneration and Repair @edinuni-irr.bsky.social · 10mo ago

£70 million investment in IRR spinout Trogenix to tackle aggressive cancers. The funding will enable the rapid advancement of its pipeline of potentially curative cancer therapies across multiple treatment-resistant cancers regeneration-repair.ed.ac.uk/ps70-million... @edinnovations.bsky.social

A man in a lab coat stands in a laboratory witht he background lab lit up in purple and blue

@lyons-lab.bsky.social · 12mo ago

www.nature.com/articles/s41...

FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system - Nature Communications

The homeostasis of myelin in the central nervous system is highly regulated, but the underlying mechanisms are unclear. Here, the authors show that the FBXW7 protein has a role in constraining myelin ...

nature.com

MariaEichelVogel.bsky.social @mariaeichelvogel.bsky.social · 12mo ago

Brilliant Kick off day #ISNASN2025 @neurochemistry.org with the best conference views ever 😎 Glad to be part of it #TogetherForScience If you wanna know more about my work on axons & zebrafish in the @lyons-lab.bsky.social join me during the poster session tmr evening (LBA45) or just reach out 🐠

@lyons-lab.bsky.social · last yr.

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...

Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience

Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...

nature.com

Steffen Scholpp @scholpplab.bsky.social · last yr.

The LSI Exeter invites you to join the first UK Zebrafish Meeting, 10/ - 12/9/ @lsiexeter.bsky.social. We are looking for motivated PhD students/ECRs to present their work - as talks and posters. www.exeter.ac.uk/research/ins... . The deadline for the early bird registration is 15/5/. So, be quick!

@lyons-lab.bsky.social · last yr.

Fun to have contributed a little to this, led by the team of the incomparable Guoqiang Yu. Suspect that this will prove to be an immensely popular image analysis platform for interrogation of dynamic signallingl! www.sciencedirect.com/science/arti...

Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals

Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new…

sciencedirect.com

Philip Hasel @philiphasel.bsky.social · last yr.

Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates

Hasel et al. show that molecularly and morphologically specialized astrocytes make up the brain and spinal cord surface, thereby creating the glia limitans superficialis. These astrocytes selectively ...

cell.com

@lyons-lab.bsky.social · last yr.

Two new opportunities in Edinburgh: Research technician in our lab elxw.fa.em3.oraclecloud.com/hcmUI/Candid... Senior research technician to support the Zebrafish Imaging and Screening Facility elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

em3.oraclecloud.com

@lyons-lab.bsky.social · 2y ago

One week to go before application deadlines... 1. Postdoc, investigating how neurons respond to demyelination. 2. Research assistant, investigating how conduction properties are established in neural circuits elxw.fa.em3.oraclecloud.com/hcmUI/Candid... elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

elxw.fa.em3.oraclecloud.com

@lyons-lab.bsky.social · 2y ago

Couple of opportunities up to join the group! One at postdoc level, but open to senior support path. One research assistant role. Please share, or drop a line if you want to learn more! Or just apply! Thanks! elxw.fa.em3.oraclecloud.com/hcmUI/Candid... elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

@lyons-lab.bsky.social · 2y ago

First post at this side. Latest axon diameter action led by Jenea Bin, in collaboration with Nolan, Mobius, Monk, Werner, and Emery labs. www.biorxiv.org/content/10.1...

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes

Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linea...

biorxiv.org