Dr. Matheson hopes to soon start their own lab to explore how biological and sociocultural factors converge to impact substance use health and to build towards development of sex- and gender-informed treatments for SUDs. #cannabis #THC #cannabinoid #research #driving #sex #gender #SUD #Treatment

Their own research program focuses on understanding how sex, gender, and intersecting social factors influence cannabis use and substance use health, with the goal of improving prevention and treatment of substance use disorders (SUDs). @camhnews.bsky.social

Meet @tc3consortium.bsky.social Fellow Alum Dr. Justin Matheson @justinrmatheson.com! Dr. Justin Matheson is currently the Research Manager of the Driving Simulator Laboratory at the Centre for Addiction and Mental Health, where they support a range of projects related to cannabis and impairment.

🚨 NEW PAPER 🚨 @brainsbeesbikes.bsky.social and I examined how acute oral THC influences the neural mechanisms of cognitive reappraisal in PTSD using fMRI. Compared with placebo, 5 mg and 10 mg THC reduced recruitment of prefrontal control regions during negative emotion reappraisal shorturl.at/m9Ihr

Dose-related reductions in prefrontal recruitment during cognitive reappraisal following oral delta-9-tetrahydrocannabinol in posttraumatic stress disorder

Neuropsychopharmacology - Dose-related reductions in prefrontal recruitment during cognitive reappraisal following oral delta-9-tetrahydrocannabinol in posttraumatic stress disorder

shorturl.at

Check out the recent collaborative paper by @tc3consortium.bsky.social fellows and trainees Adam Zaweel, @justinrmatheson.com, Madison Wright, PhD and TC3 members Bernard Le Foll, Bruna Brands, Beth Sproule, Christine Wickens, and Patricia Di Ciano et al. www.nature.com/articles/s41...

Potency-related effects of smoked cannabis on simulated driving performance: a randomized, controlled crossover trial - Scientific Reports

Scientific Reports - Potency-related effects of smoked cannabis on simulated driving performance: a randomized, controlled crossover trial

nature.com

Meet @tc3consortium.bsky.social Fellow Christina Pereira! Christina is a PhD. candidate at the Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto under the supervision of Dr. Isabelle Boileau and Dr. Stefan Kloiber. #endocannabinoid #socialanxiety #stress

Heading off to France for #ICRS2026 Re-sharing the cannabis starter pack I made since I haven't updated this in a long time - let me know if you want to be added!

Justin Matheson, PhD (he/they)@justinrmatheson.com · 2y ago

I've started a new cannabis research starter pack! It's a work in progress - please reply here or message me if you want to be added :) I know I'm missing a lot of folks here, just threw something together quickly go.bsky.app/FPKwE4w

With the rumblings around CIHR wanting to move to one cycle per year not going away, in consultation with a diverse stakeholder group, we have put together a letter for CIHR leadership. Please consider signing this letter and share/RT: docs.google.com/forms/d/e/1F... @cannabrain.bsky.social

CIHR Project Grant Cycle Restructuring

Dear colleagues, Below you will find a draft letter regarding the proposed transition to a single annual CIHR Project Grant competition, and to invite you to sign on if you are in agreement with its c...

docs.google.com

📅 Wednesday at #OSSD2026: ✔️ Symposia on molecular insights, environmental toxicants, women's health, GLP-1 therapeutics, and Biology of Sex Differences Hot Topics ✔️ Poster Session II ✔️ Social Responsibility Lunch ✔️ Elizabeth Young New Investigator Awards ✔️ CIHR Canadian Research Reception

Join us at our 2nd Annual TC3 workshop on EDI in Cannabis and Cannabinoid Research on May 27, 2026 at University of Toronto's Chestnut Conference Centre. Register now to secure your seat! UofT &TAHSN Community Link: tinyurl.com/mr3sk89a @ccicbluesky.bsky.social #cannabis #EDI #cannabinoid #workshop

Matheson et al. report that adults who use cannabis showed no measurable cognitive deficits 12–15 h after smoking compared to controls, though subjective drug effects remained elevated. Higher THC potency/concentrations were linked to poorer memory and slower processing. doi.org/10.1016/j.da...

New from our team at CAMH - we find nuanced evidence for next-day performance effects of smoked cannabis, likely associated with higher-THC-potency products www.sciencedirect.com/science/arti...

Cognitive performance and subjective effects the morning after last use of smoked cannabis by adults who use cannabis frequently: An observational study

To examine next-day cognitive performance and subjective drug effects after smoking cannabis and to assess associations between performance and cannab…

sciencedirect.com

🚨 Only 6 of 29 studies on #cannabis’ acute cognitive effects found #sex differences! New #review highlights gaps: small samples, poor sex/gender measurement, and no inclusion of trans/gender-diverse participants 🧠 #CannabisResearch #SexDifferences https://ow.ly/7Tzi50Yh71A

Congratulations to TC3 fellows and alumni @justinrmatheson.com, @camielnik.bsky.social & Claire Shyu for an outstanding symposium about integrating sex- &gender-based analysis into #cannabinoid #research at Canadian Organization for Gender & Sex Research's International Meeting tinyurl.com/yc6xs4m9

Congratulations to TC3-Toronto Cannabis and Cannabinoid Research Consortium fellows and alumni Justin Matheson, PhD, Catharine Mielnik, PhD and Claire Shyu, PhD for putting together an outstanding… | ...

Congratulations to TC3-Toronto Cannabis and Cannabinoid Research Consortium fellows and alumni Justin Matheson, PhD, Catharine Mielnik, PhD and Claire Shyu, PhD for putting together an outstanding sym...

linkedin.com

Thanks a million @wildsoundfestival.bsky.social for our Award Winner status on our spec script, Awaken the Medium. We are #grateful festivalreviews.org/2026/01/25/7... #Screenplay #Thriller #Suspense #spiritual

Interview with Screenwriters Lee Bice-Matheson, Kevin Matheson (AWAKEN THE MEDIUM)

Awaken the Medium is a feature-length script that follows the story of Maggie Samson, whose latest near-death experience thrusts her into discovering her gifts and powers. Maggie is a librarian in …

festivalreviews.org

Registration is now open for the Canadian Cannabis Research Summit Includes a 1-day EDI in cannabis research workshop (May 27) + main conference (May 28–29) Early bird rates end Feb 28 Learn more: ccic.net/ccic-conference Register here: lnkd.in/gznYMaMJ Submit an abstract: lnkd.in/gUiS5ZBM

Thrilled to share a new commentary paper!! Sex differences in the acute effects of cannabis: the need for hypothesis-driven research cdnsciencepub.com/doi/full/10....

Sex differences in the acute effects of cannabis: the need for hypothesis-driven research

Sex and gender can impact cannabis use and related harms, yet the field has historically centered men and male bodies. In our recent systematic review of sex differences in the acute cognitive effects...

cdnsciencepub.com

We’re excited to announce the upcoming ICRS Training Seminar: Beyond Academia: Expanding your Career Possibilities 📆Thursday, January 22nd ⏰12:00 PM EST 👉Free to Attend with Registration: tinyurl.com/icrswebinar Reserve your spot today and take the next step toward shaping your future!

Academia problems - I don't have time to finish a paper I started over a year ago because other more urgent papers keep popping up.

📣 SAVE THE DATE: May 27-29, 2026 for the Canadian Cannabis Research Summit and TC3 EDI Workshop at the University of Toronto! We are excited to partner once again with the Canadian Consortium for the Investigation of Cannabinoids. Details To Come! #cannabis #cannabinoids #research @utoronto.ca

Thrilled to share a new systematic review where we examined sex differences in the acute cognitive effects of cannabis in humans Overall, not much evidence of sex diffs (6/29 studies, 8/216 variables found sex diffs) BUT... www.sciencedirect.com/science/arti...

Sex differences in the acute effects of cannabis on human cognition: A systematic review

Acute cannabis exposure can transiently impair cognitive performance, increasing the risk of accidental injury and potentially disrupting activities o…

sciencedirect.com

New @pact-lab.bsky.social paper out today led by [current postdoc] Gavin Petrie & [former postdoc] Raegan Mazurka exploring how acute alcohol impacts endocannabinoid levels & their relation to the subjective effects of alcohol 🍻 link.springer.com/article/10.1...

Effects of acute alcohol administration on endocannabinoids and relation to subjective effects - Psychopharmacology

Rationale Harmful alcohol use remains a significant global public health challenge. Examining variability in the acute subjective effects of alcohol and related neurobiological mechanisms may advance the understanding of susceptibility to harmful alcohol use. Research suggests the endocannabinoid (eCB) system may play an important role in mediating the reinforcing effects of alcohol. This study examined the relationship between alcohol-induced changes in eCB concentrations and the subjective psychoactive effects of acute alcohol consumption. Method Healthy social drinkers (n = 28, aged 20–35 years) participated in a within-subjects, single-blind, placebo-controlled laboratory alcohol challenge study. Alcohol (0.6 g/kg; with 20% adjustment for women) and placebo sessions were counterbalanced. Subjective alcohol effects were assessed from self-report questionnaires administered pre- and post-dosing, including the Biphasic Alcohol Effects Scale (BAES), Drug Effects Questionnaire (DEQ), and Profile of Mood States (POMS). The eCBs, N-arachidonoylethanolamine (anandamide; AEA) and 2-arachidonylglycerol (2-AG), were assessed from blood plasma taken throughout the dosing session. Results Acute alcohol was associated with an overall decrease in 2-AG concentrations compared to placebo. Further, we found that a drop in 2-AG concentrations was associated with less drug ‘liking’ and feelings of ‘friendliness’, whereas under placebo conditions, a rise in 2-AG was associated with a smaller decrease in feelings of ‘stimulation’ (e.g., feeling energized, talkative). Alcohol did not significantly affect AEA concentrations. Conclusion Our study provides the first evidence that eCBs may contribute to individual differences in sensitivity to alcohol's reward-related mechanisms by influencing subjective experience, offering insight into the potential role of eCBs in the processes underlying harmful alcohol use.

link.springer.com

Our new paper published in Psychiatry Research: Daily associations between posttraumatic stress disorder, cannabis use, and negative affect among veterans. #PTSD #veterans @iasatusc.bsky.social @uscpsychiatry.bsky.social @leightley.bsky.social www.sciencedirect.com/science/arti...

New Cannabis publication! Cannabis Use Characteristics and Reasons for Product Choices Among Patients Accessing Treatment for Substance Use Disorders: A Mixed-Methods Study. Big collaborative effort across 19 affiliations led by @justinrmatheson.com. publications.sciences.ucf.edu/cannabis/ind...

Check out our new pre-print protocol - we're setting out on a journey to examine the scope of existing evidence for sex and gender influences on problematic cannabis use, including cannabis use disorder www.medrxiv.org/content/10.1...

Sex and Gender Influences on Problematic Cannabis Use and Cannabis Use Disorder: A Scoping Review Protocol

Introduction Cannabis use and cannabis use disorder (CUD) are more prevalent among men and boys than among women and girls. However, this sex/gender gap has been narrowing in recent decades, likely du...

medrxiv.org

Pleased to share a new article published today - we examined relationships between cannabis use and mental health characteristics in patients accessing treatment for substance use disorders (SUDs) In Ontario, Canada www.tandfonline.com/eprint/YMGZT...

Associations Between Cannabis Use and Mental Health in Patients Accessing Treatment for Substance Use Disorders: An Exploratory Cross-Sectional Study

Background: Cannabis use is common among individuals with substance use disorders (SUDs), yet its relationship with mental health characteristics in treatment-seeking populations remains unclear. O...

tandfonline.com

Happy Pride Month! Did you know that 2SLGBTQ+ people have higher rates of cannabis use than cis, straight people? Bisexual women appear to have the highest rates Read more in this fantastic review from Christina Dyar: link.springer.com/article/10.1...

A Review of Disparities in Cannabis Use and Cannabis Use Disorder Affecting Sexual and Gender Minority Populations and Evidence for Contributing Factors - Current Addiction Reports

Purpose of Review Sexual and gender minorities (SGM) appear to be at elevated risk for cannabis use (CU) and cannabis use disorder (CUD) compared to cisgender heterosexuals. However, risk factors rema...

link.springer.com

New pilot cannabinoid RCT just dropped! We examined feasibility and preliminary efficacy of nabilone for body weight reduction in adults in obesity, and also looked for some potential mechanisms. Long story short - the drug regimen was not well tolerated www.liebertpub.com/doi/10.1089/...

Feasibility and Tolerability of Nabilone for the Treatment of Obesity: A Randomized Controlled Pilot Trial | Cannabis and Cannabinoid Research

Introduction: In epidemiological studies, people who use cannabis have a lower prevalence of obesity. Furthermore, the endocannabinoid system is recognized as a potential target for obesity treatment ...

liebertpub.com

Thrilled to share a new article! We found a decline in the male-to-female ratio of lifetime cannabis use prevalence among adults in Ontario, (maybe in adults aged 30 or older only?) Huge thanks to my co-authors @camhnews.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Changes in the Sex/Gender Gap in Cannabis Use in Ontario, Canada From 2001 to 2019

Introduction Although cannabis use has been historically higher in men than women, some research suggests a narrowing of the sex/gender gap in recent decades. We characterised trends in cannabis use...

onlinelibrary.wiley.com

Announcing Dr. Akwasi Owusu-Bempah as one of our #keynote speakers at the TC3's "EDI in #Cannabis & #Cannabinoid #Research" Workshop. Join us on April 22 - 23, 2025 at the Chestnut Conference Centre at @uoft.bsky.social. Register here: tinyurl.com/44rasves. You don't want to miss this!