Josh Waitzman
@jwaitz.bsky.social
Kidney doc, biochemist, and dad, taking life one kinesin-sized step at a time. He/him. Employed by Vertex Pharmaceuticals | BIDMC Nephrology | opinions my own
If you read only one obit of James Watson, read this one www.statnews.com/2025/11/07/j... (From the late Sharon Begley, for @statnews.com )
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
statnews.com
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk Simultaneous pub in NEJM www.nejm.org/doi/full/10....
Today’s trials at #KidneyWk In the morning a LBCT session at 10:30 featuring PISCES (fish oil in dialysis!) LIBERATE in AKI Another AKI alerts from @fperrywilson.bsky.social A Transplant trial GLP1 and a Flozin analyses And
New to the #KidneyWk Opening Plenary: two High-Impact Clinical Trials debut this morning, presenting pivotal data in CKD and IgAN. These groundbreaking studies take the main stage at Kidney Week for the first time—you don’t want to miss this.
Don’t forget to support #FOAMed and #NephJC with our annual fundraiser. Every donation helps keep us going (even as unpaid volunteers). 🫶🫶🫶 www.nephjc.com
If treatments are available that can help at early stages of most causes of CKD (RAASi, SGLT2i, etc), why WOULDN’T we screen? Economics? How much does saving 20 years of dialysis get you? What about human costs? www.kireports.org/article/S246...
Urine screening to early diagnose young individuals with CKD: a call for action
Alport syndrome is an inherited disorder of basement membranes leading to progressive chronic kidney disease, hearing loss, and ocular abnormalities in many affected patients. When the authors started...
kireports.org
In case folks missed this, ACGME Transplant Nephrology accreditation is now a thing! If folks are Program Directors, they may need to start the process of accreditation soon. Requirements here: www.acgme.org/globalassets...
acgme.org
In this house we drink liquids and support #nephjc (Maybe I should get a backpack next time) Donate at: www.nephjc.com/news/2025/9/...
This is a powerful account from a PhD student whose fellowship was terminated by NIH because it was part of a "diversity" program without any other considerations or understanding of what the program or the students were actually doing. undark.org/2025/10/09/o... 1/2
NIH Student Grant Cancellation Will Weaken Scientific Innovation
The termination of federal F31 diversity fellowships puts many graduate students in a bind — and U.S. science at risk.
undark.org
Pre #nephjc bias: Team pro protein All these studies are deeply confounded and based in the pre-kidney-preserving therapy era. Let them eat steak! (Actually, let them eat vegetable sources of protein, but beans, lentils, and soy don’t rhyme with cake)
a cartoon character from the simpsons is holding a bottle of protein
ALT: a cartoon character from the simpsons is holding a bottle of protein
media.tenor.com
Nephrology Journal Club@nephjc.bsky.social · 10mo ago🗓️Join us 10/14/25 as we discuss: Are you team PRO protein 💪 or team RESTRICT protein 🥗 The strategies seem to shift somewhat as CKD progresses to ESRD. What's the evidence say 🤔? 🕰️9pm EST only on Bluesky. #NephSky #MedSky www.nephjc.com/news/proteins-eskd
Loved watching @kidneyrebel.bsky.social grand rounds at @nu-nephrology.bsky.social!! Thank you for the PKD mega blocks shout out #nephjc (1), happy to be at the right overlap in my Venn diagram (2), and trying to build toward a medical specialty in a hill (3) www.youtube.com/watch?v=RlTC...
New episode of Channel Your Enthusiasm, part 2 of 3 on metabolic acidosis. Episode with chapter art, chapters, and fully referenced www.rosebook.club/episodes/202...
a woman is smiling with the words " what are you smoking " above her
ALT: a woman is smiling with the words " what are you smoking " above her
media.tenor.com
American Journal of Hypertension@amjhypertension.bsky.social · 10mo agoThe endocannabinoid system as a target for thiazide diuretics? academic.oup.com/ajh/advance-... #WeekendReads from the #AdvanceArticles section
a group of men are sitting around a table with a phone .
ALT: a group of men are sitting around a table with a phone .
media.tenor.com
@jsxover.bsky.social · 10mo agoIgA is pronounced eye-gee-ay The reason the disease should be called "eye-gee-ay nephropathy" is because IgA is central to the pathogenic mechanism. Moving to eye-gan is moving away from describing the disease by its pathogenic mechanism.
My op-ed just came out discussing how NIH leadership is failing early career researchers and, importantly, how we can push back and take our future into our own hands.
NIH Leadership Is Failing Early Career Researchers
Halted training programs, funding chaos, and hiring freezes jeopardize advancement options for early career researchers.
the-scientist.com
Thought-provoking, well-written @nejm.org blog article by Dr. Paul Farmer's wife on the (third) anniversary of his passing: www.nejm.org/doi/10.1056/... cc: @jwaitz.bsky.social #nephjc summer book club chat
In Paul Farmer’s Beautiful Garden of Global Health Equity: Reflections on the Third Remembrance of His Passing | NEJM
On the third anniversary of Paul Farmer’s death, Didi Bertrand Farmer reflects on his “beautiful garden” — a vision of social justice in health care, with deep roots in the fertile soil of equity.
nejm.org
Perhaps we can help! Great commentary by @nephroseeker.bsky.social www.nephjc.com/news/2025/30...
Immune tolerance in kidney transplantation: from first principles to clinical engineering — NephJC
A commentary putting the chimerism and immune tolerance in perspective
nephjc.com
rdcu.be/eJHTr rdcu.be/eJHU8 www.sciencedirect.com/science/arti... www.annualreviews.org/content/jour...
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
Nature Reviews Immunology - In this Review, the authors discuss the origins of regulatory T (Treg) cells in the periphery and the mechanisms by which Treg cells are induced, as well as the...
rdcu.be
I guess this means it’s time for me to try to understand what Tregs do… (Thanks @enirenberg.bsky.social for the great explainer!)
Edward Nirenberg@enirenberg.bsky.social · 10mo agoThis year's Nobel Prize in Physiology or Medicine was just announced: www.nobelprize.org/prizes/medic... This seems like a good opportunity for me to explain a bit about peripheral immune tolerance and where the prizewinners' work comes in 🧵
PARASOL Project is expanding focus to include biomarkers & endpoints in APOL1 kidney disease and primary MN as well as FSGS. Learn more: eu1.hubs.ly/H0nr8Lv0 @tobias-b-huber.bsky.social @miktmc.bsky.social @jarcyzphd.bsky.social @ohiostatemed.bsky.social @utoronto.ca @nu-nephrology.bsky.social
PARASOL Project Expands Focus to APOL1, Membranous Nephropathy
PARASOL Project expands to focus on APOL1 kidney disease and primary membranous nephropathy, aiming to improve clinical trial endpoints for these conditions.
eu1.hubs.ly
Today is #C3GAwarenessDay! At ISGD, we stand with people living with this rare kidney disease. As a medical society for #GlomerularDisease experts, we're committed to raising awareness and moving the science forward to bring more hope and solutions to the C3G community. #C3G #ISGD
Excellent thread below I will also plug this talk by Paola Romagnani on podocytopathies youtu.be/bRMeqaGgA9I?... #GlomCon #NephGR
Personalized Therapy for Podocytopathies with Prof. Paola Romagnani
YouTube video by Ottawa Nephrology
youtu.be
Joel Topf@kidneyboy.bsky.social · 11mo agoNext up Podocytopathies with ASstrid Weins who calls out that she is wearing a geography appropriate flowered dress #GlomCon
Reposting a q I had re the lower treatment threshold/goal for #nephjc
Josh Waitzman@jwaitz.bsky.social · 11mo agoCongrats Jordy and team on this enormous effort! I love a good risk score as much as the next guy, but does this overcomplicate things for those around 130/80? Even the commentary says that most folks with who start lifestyle change will need meds, and ARBs are better tolerated than placebo.
Here is a word cloud of the words that were missing from the noncompetitive renewal awards but had been present in the parent award. 3/4
This is the longest a pig organ has survived in a living person go.nature.com/42dgjzo
‘Amazing feat’: US man still alive six months after pig kidney transplant
The first six months after an organ transplant are the riskiest for recipients.
go.nature.com
