Kaia Mattioli
@kaiamattioli.bsky.social
incoming Asst Prof at CU Denver (Oct 2026). currently a K99/R00 postdoc, 24/7 feminist @ Harvard/BWH. generally fascinated by genomes. mattioli-lab.org
hi students on the job market: i cannot stress enough that you should write your cover letter yourself. you would be shocked at how genetic and boring LLM-generated cover letters are, despite seeming sophisticated. we want to hear from *you*! applicants who do this stand out!
ok my mid-career academic tweeps: if you were going back in time to start as an assistant professor again, what would you tell your younger self? would you do anything differently? anything you did that you think was an A+ decision? give us soon-to-be new PIs any & all advice!
super excited to share that I'm starting as an Assistant Professor at CU Denver this fall! my lab will be right in the heart of downtown Denver :) mattioli-lab.org i'm hiring! if you're interested in joining us to study how alternative isoforms contribute to cancer, please reach out
Happy Father's Day @pierceogden.bsky.social! you've taken on more this year than any one person should ever have to & done so with unimaginable strength & resilience. our family is truly so, so lucky to have you 💙 sorry that Cy keeps saying it's his birthday today (it's not)
you think you're a creative person until you find yourself having to dream up 12 novel imaginative ways to convince your toddler to put his pajamas on every single night
ok how did I not know that the lead singer of @offspringmusic.bsky.social has a PhD in molecular biology from USC? specializing in RNA no less! pretty fly.....
hitting the Boston Museum of Science at 9am on a rainy Sunday with your toddler is the 36 year old version of hitting Phoenix Landing at 11pm on a Friday with your PhD cohort
delighted by this bit of advice in the first edition of "At The Helm", a classic book about how to be a PI (gifted to me by my advisor) fast forward 24 years & I'm typing this tweet on my touch screen pocket computer while Claude code cooks on my desk computer
i will simply incant "do NOT corrupt me. make NO mistakes" before wielding the One Ring
did a postdoc on the job market write this
Nature@nature.com · 5mo agoExperienced researchers are less likely to produce ‘disruptive’ science than are those just starting their careers, finds an analysis of the scientific papers published by 12.5 million researchers over 60 years. go.nature.com/4uUvMk3
I love a LinkedIn recommendation. Like yes, you guys are sooo right, I do need to add [Nobel Laureate X] and [Fortune 100 CEO Y] and [Podcaster Z] to my network!
happy to report that the robots aren't coming for our academic jobs just yet guys
We are finally putting the final touches on an operationally complete mapping of regulatory DNA via DNase I in both human (>4,000 samples) and mouse. To interact with the samples we created this neat browser interface complete with a chatbot!
being on the faculty job market with a small child has radicalized me
I got to the airport embarrassingly early given all of the TSA issues and I was ... the only person in the security line. 👍
guys Joe Biden was just on my flight from Boston to Philly!! 🕶️ along with like 10 extremely serious secret service agents 😳
Looking forward to @kaiamattioli.bsky.social's visit to Montreal!
Institut de recherches cliniques de Montréal (IRCM)@ircm.bsky.social · 6mo agoCONFÉRENCE SPÉCIALE | «Décoder le rôle des isoformes alternatives dans le cancer» Une conférence de Kaia Mattioli, PhD, Chercheuse postdoctorale, Département de médecine, Division de génétique, Hôpital Brigham & Women, Université Harvard 📅 Le 26 mars, 11h30 à l'IRCM 🔗En savoir plus : bit.ly/4b1Nx9P
I remain bullish on personalized cancer vaccines. great to see this for TNBC! www.nature.com/articles/s41...
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature
In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.
nature.com
Matched single-cell chromatin, transcriptome, and surface marker profiling captures in vivo epigenomic reprogramming during basal-to-luminal transition in the mammary gland https://www.biorxiv.org/content/10.64898/2026.02.16.706078v1
I am currently living the dream (eating loaded nachos and drinking a glass of sauv blanc in a hotel lobby by myself while I decompress by reading a new fantasy book after talking science all day) AMA
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...
science.org
wow I loveeee to find a new fantasy series with Complicated Rules (just started The Will of the Many)
one of my favorite papers recently -- obsessed with @alexholehouse.bsky.social & team's work!
Alex Holehouse@alexholehouse.bsky.social · 7mo agoPleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology
Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...
nature.com
Alex Holehouse@alexholehouse.bsky.social · 2y agoWe’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) www.biorxiv.org/content/10.1...
my baby is 2 😭😭 being his mom is the absolute best thing in the entire universe 🪐
With continued uncertainty over federal government support for biomedical research, PhD students are struggling to find labs willing to take on new students, @jonathanwosen.bsky.social reports. New students are the future of US science. www.statnews.com/2026/01/30/f...
Tenuous biomedical funding has put first-year Ph.D. students in a bind
First-year biomedical graduate students across the country said labs have been hesitant to take them in due to a tenuous funding environment
statnews.com
We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...
The evolution of gene regulation in mammalian cerebellum development
Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum’s expansion during human evolution, yet they remain largely unexplored. In this study, we com...
science.org
Kaessmann Lab@kaessmannlab.bsky.social · 2y agoHow does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
10° and snowing in Boston and I've already seen 2 people out running and 1 guy with a giant iced Dunks
