Check out our new paper in @commschem.bsky.social, where we identified a novel enantioselective fragment for the deubiquitinating enzyme, OTUD7B. An absolute pleasure to co-lead this project with Aini Vuorinen and @cassandrakennedy.bsky.social! www.nature.com/articles/s42...
Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation - Communications Chemistry
The ovarian tumour protease (OTU) family of deubiquitinating enzymes (DUBs) are biochemically well-characterised and of therapeutic interest, however, only a few tool compounds exist to study their ce...
nature.com
Dr Cassandra Kennedy@cassandrakennedy.bsky.social · 2y agoHappy to share our new paper, out now in @commschem.bsky.social. Was great working with Aini and @katmcphie.bsky.social on this! We used chemoproteomics and HTC to find an enantioselective hit for OTUD7B. www.nature.com/articles/s42... @katrinrittinger.bsky.social @jtbush.bsky.social @crick.ac.uk